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Effectiveness of a 2+1 dose schedule pneumococcal conjugate vaccination programme on invasive pneumococcal disease among children in Norway.
Vaccine. 2008 Jun 19; 26(26):3277-81.V

Abstract

The 7-valent pneumococcal conjugate vaccine (PCV-7) was licensed in Norway in 2001. In July 2006, PCV-7 was introduced in the Norwegian Childhood Vaccination Programme in a 2+1 dose schedule, with immunizations administered at 3, 5 and 12 months of age. PCV-7 was offered through the vaccination programme to all children born from January 2006, i.e. a catch-up for children aged 3-6 months. Prior to 2006 the use of PCV-7 was negligible. The effectiveness of the PCV-7 vaccination programme was assessed using data on invasive pneumococcal disease (IPD) incidence obtained from the Norwegian Surveillance System for Communicable Diseases, serotype distribution from the National Reference Laboratory for Pneumococci, and vaccine coverage and vaccination status from the Norwegian National Vaccination Register. Vaccine coverage quickly reached high levels; 95% of children >3 months born from January 2006 had received at least one immunization with PCV-7. The incidence rate of IPD among children <2 years rapidly declined; the rate of vaccine serotype IPD in this age group fell from an average of 47.1 cases/100,000 population in the 2 years prior to PCV-7 introduction to 13.7 cases/100,000 population in 2007. The incidence rate of nonvaccine serotype IPD remained stable. The vaccine programme effectiveness was estimated to be 74% (95% CI 57-85%). No vaccine failure was seen after complete primary immunization with two vaccine doses. Our findings indicate that PCV-7 provides highly effective protection against vaccine serotype IPD when administered in a 2+1 dose schedule.

Authors+Show Affiliations

Division of Infectious Disease Control, Norwegian Institute of Public Health, Nydalen, Oslo, Norway. didrik.frimann.vestrheim@fhi.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18456376

Citation

Vestrheim, Didrik F., et al. "Effectiveness of a 2+1 Dose Schedule Pneumococcal Conjugate Vaccination Programme On Invasive Pneumococcal Disease Among Children in Norway." Vaccine, vol. 26, no. 26, 2008, pp. 3277-81.
Vestrheim DF, Løvoll O, Aaberge IS, et al. Effectiveness of a 2+1 dose schedule pneumococcal conjugate vaccination programme on invasive pneumococcal disease among children in Norway. Vaccine. 2008;26(26):3277-81.
Vestrheim, D. F., Løvoll, O., Aaberge, I. S., Caugant, D. A., Høiby, E. A., Bakke, H., & Bergsaker, M. R. (2008). Effectiveness of a 2+1 dose schedule pneumococcal conjugate vaccination programme on invasive pneumococcal disease among children in Norway. Vaccine, 26(26), 3277-81. https://doi.org/10.1016/j.vaccine.2008.03.087
Vestrheim DF, et al. Effectiveness of a 2+1 Dose Schedule Pneumococcal Conjugate Vaccination Programme On Invasive Pneumococcal Disease Among Children in Norway. Vaccine. 2008 Jun 19;26(26):3277-81. PubMed PMID: 18456376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of a 2+1 dose schedule pneumococcal conjugate vaccination programme on invasive pneumococcal disease among children in Norway. AU - Vestrheim,Didrik F, AU - Løvoll,Oistein, AU - Aaberge,Ingeborg S, AU - Caugant,Dominique A, AU - Høiby,E Arne, AU - Bakke,Hilde, AU - Bergsaker,Marianne R, Y1 - 2008/04/18/ PY - 2008/03/06/received PY - 2008/03/28/revised PY - 2008/03/31/accepted PY - 2008/5/6/pubmed PY - 2008/9/10/medline PY - 2008/5/6/entrez SP - 3277 EP - 81 JF - Vaccine JO - Vaccine VL - 26 IS - 26 N2 - The 7-valent pneumococcal conjugate vaccine (PCV-7) was licensed in Norway in 2001. In July 2006, PCV-7 was introduced in the Norwegian Childhood Vaccination Programme in a 2+1 dose schedule, with immunizations administered at 3, 5 and 12 months of age. PCV-7 was offered through the vaccination programme to all children born from January 2006, i.e. a catch-up for children aged 3-6 months. Prior to 2006 the use of PCV-7 was negligible. The effectiveness of the PCV-7 vaccination programme was assessed using data on invasive pneumococcal disease (IPD) incidence obtained from the Norwegian Surveillance System for Communicable Diseases, serotype distribution from the National Reference Laboratory for Pneumococci, and vaccine coverage and vaccination status from the Norwegian National Vaccination Register. Vaccine coverage quickly reached high levels; 95% of children >3 months born from January 2006 had received at least one immunization with PCV-7. The incidence rate of IPD among children <2 years rapidly declined; the rate of vaccine serotype IPD in this age group fell from an average of 47.1 cases/100,000 population in the 2 years prior to PCV-7 introduction to 13.7 cases/100,000 population in 2007. The incidence rate of nonvaccine serotype IPD remained stable. The vaccine programme effectiveness was estimated to be 74% (95% CI 57-85%). No vaccine failure was seen after complete primary immunization with two vaccine doses. Our findings indicate that PCV-7 provides highly effective protection against vaccine serotype IPD when administered in a 2+1 dose schedule. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/18456376/Effectiveness_of_a_2+1_dose_schedule_pneumococcal_conjugate_vaccination_programme_on_invasive_pneumococcal_disease_among_children_in_Norway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(08)00421-0 DB - PRIME DP - Unbound Medicine ER -