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Pharmacokinetics of azithromycin in serum and sinus fluid after administration of extended-release and immediate-release formulations in patients with acute bacterial sinusitis.
Int J Antimicrob Agents. 2008 Jun; 31(6):561-6.IJ

Abstract

As high drug levels at the infection site are desirable for optimal activity, this study explored whether one dose of azithromycin extended release (AZ-ER) achieved higher azithromycin exposure in sinus fluid than azithromycin immediate release (AZ-IR) in adults with acute bacterial sinusitis. Subjects received AZ-ER (2g single dose; n=5) or AZ-IR (500mg daily for 3 days; n=4) and blood and sinus aspirates were collected until 120 h after initial dosing. Within 24 h, exposure was four- and three-fold higher with AZ-ER than with AZ-IR in serum and sinus fluid, respectively. Sinus fluid exposure was five- and three-fold higher than serum for AZ-IR and AZ-ER, respectively. Azithromycin concentrations in sinus fluid were maintained up to 120 h.

Authors+Show Affiliations

Department of Clinical Science, Intervention and Technology, Division of Otorhinolaryngology, Karolinska Institutet, and Nacka Närsjukhus Proxima AB, Stockholm, Sweden. jadelinia@hbase.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18456465

Citation

Ehnhage, A, et al. "Pharmacokinetics of Azithromycin in Serum and Sinus Fluid After Administration of Extended-release and Immediate-release Formulations in Patients With Acute Bacterial Sinusitis." International Journal of Antimicrobial Agents, vol. 31, no. 6, 2008, pp. 561-6.
Ehnhage A, Rautiainen M, Fang AF, et al. Pharmacokinetics of azithromycin in serum and sinus fluid after administration of extended-release and immediate-release formulations in patients with acute bacterial sinusitis. Int J Antimicrob Agents. 2008;31(6):561-6.
Ehnhage, A., Rautiainen, M., Fang, A. F., & Sanchez, S. P. (2008). Pharmacokinetics of azithromycin in serum and sinus fluid after administration of extended-release and immediate-release formulations in patients with acute bacterial sinusitis. International Journal of Antimicrobial Agents, 31(6), 561-6. https://doi.org/10.1016/j.ijantimicag.2008.01.027
Ehnhage A, et al. Pharmacokinetics of Azithromycin in Serum and Sinus Fluid After Administration of Extended-release and Immediate-release Formulations in Patients With Acute Bacterial Sinusitis. Int J Antimicrob Agents. 2008;31(6):561-6. PubMed PMID: 18456465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of azithromycin in serum and sinus fluid after administration of extended-release and immediate-release formulations in patients with acute bacterial sinusitis. AU - Ehnhage,A, AU - Rautiainen,M, AU - Fang,A F, AU - Sanchez,S P, Y1 - 2008/05/05/ PY - 2007/10/29/received PY - 2008/01/24/revised PY - 2008/01/24/accepted PY - 2008/5/6/pubmed PY - 2008/7/26/medline PY - 2008/5/6/entrez SP - 561 EP - 6 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 31 IS - 6 N2 - As high drug levels at the infection site are desirable for optimal activity, this study explored whether one dose of azithromycin extended release (AZ-ER) achieved higher azithromycin exposure in sinus fluid than azithromycin immediate release (AZ-IR) in adults with acute bacterial sinusitis. Subjects received AZ-ER (2g single dose; n=5) or AZ-IR (500mg daily for 3 days; n=4) and blood and sinus aspirates were collected until 120 h after initial dosing. Within 24 h, exposure was four- and three-fold higher with AZ-ER than with AZ-IR in serum and sinus fluid, respectively. Sinus fluid exposure was five- and three-fold higher than serum for AZ-IR and AZ-ER, respectively. Azithromycin concentrations in sinus fluid were maintained up to 120 h. SN - 0924-8579 UR - https://www.unboundmedicine.com/medline/citation/18456465/Pharmacokinetics_of_azithromycin_in_serum_and_sinus_fluid_after_administration_of_extended_release_and_immediate_release_formulations_in_patients_with_acute_bacterial_sinusitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-8579(08)00074-5 DB - PRIME DP - Unbound Medicine ER -