Tags

Type your tag names separated by a space and hit enter

Fibroadenoma masquerading carcinoma on fine-needle aspiration of the breast.
Chirurgia (Bucur). 2008 Mar-Apr; 103(2):227-30.C

Abstract

OBJECTIVE

Benign and malignant lesions of the breast may have similar appearances on fine-needle aspiration cytology. We report a case of fibroadenoma that was diagnosed as carcinoma by cytology.

CASE STUDY

Breast fine-needle aspiration biopsy was highly cellular and composed of bland-appearing spindle/columnar cells that could represent either epithelial or stromal cells; the case was reported as positive and the patient had subsequent excisional biopsy taken.

RESULTS

On microscopic examination, smears were hypercellular and had many single cells and clusters of columnar/ elongate cells No obvious bipolar cells of myoepithelial origin were seen. Significant atypia was noted. Immunocytochemistry for smooth muscle actin was not performed due to insufficient material.

CONCLUSIONS

Some cases of fibroadenoma and carcinoma can be very difficult to distinguish on fine needle aspiration cytology smears. Immunocytochemistry may be of help if sufficient material is provided. To avoid false positive diagnosis on cytology, it is best to report such a case as intermediate (atypical/suspicious) with final interpretation pending excisional biopsy.

Authors+Show Affiliations

Department of Cytopathology, Regional Hospital of Chania, Crete, Greece. cyto@chaniahospital.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18457104

Citation

Tamiolakis, D, et al. "Fibroadenoma Masquerading Carcinoma On Fine-needle Aspiration of the Breast." Chirurgia (Bucharest, Romania : 1990), vol. 103, no. 2, 2008, pp. 227-30.
Tamiolakis D, Georgiou G, Barbagadaki S, et al. Fibroadenoma masquerading carcinoma on fine-needle aspiration of the breast. Chirurgia (Bucur). 2008;103(2):227-30.
Tamiolakis, D., Georgiou, G., Barbagadaki, S., Antoniou, C. h., Nikolaidou, S., Tsiminikakis, N., Economou, C., Bolioti, S., & Alifieris, E. (2008). Fibroadenoma masquerading carcinoma on fine-needle aspiration of the breast. Chirurgia (Bucharest, Romania : 1990), 103(2), 227-30.
Tamiolakis D, et al. Fibroadenoma Masquerading Carcinoma On Fine-needle Aspiration of the Breast. Chirurgia (Bucur). 2008 Mar-Apr;103(2):227-30. PubMed PMID: 18457104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibroadenoma masquerading carcinoma on fine-needle aspiration of the breast. AU - Tamiolakis,D, AU - Georgiou,G, AU - Barbagadaki,S, AU - Antoniou,Ch, AU - Nikolaidou,S, AU - Tsiminikakis,N, AU - Economou,C, AU - Bolioti,S, AU - Alifieris,E, PY - 2008/5/7/pubmed PY - 2008/6/20/medline PY - 2008/5/7/entrez SP - 227 EP - 30 JF - Chirurgia (Bucharest, Romania : 1990) JO - Chirurgia (Bucur) VL - 103 IS - 2 N2 - OBJECTIVE: Benign and malignant lesions of the breast may have similar appearances on fine-needle aspiration cytology. We report a case of fibroadenoma that was diagnosed as carcinoma by cytology. CASE STUDY: Breast fine-needle aspiration biopsy was highly cellular and composed of bland-appearing spindle/columnar cells that could represent either epithelial or stromal cells; the case was reported as positive and the patient had subsequent excisional biopsy taken. RESULTS: On microscopic examination, smears were hypercellular and had many single cells and clusters of columnar/ elongate cells No obvious bipolar cells of myoepithelial origin were seen. Significant atypia was noted. Immunocytochemistry for smooth muscle actin was not performed due to insufficient material. CONCLUSIONS: Some cases of fibroadenoma and carcinoma can be very difficult to distinguish on fine needle aspiration cytology smears. Immunocytochemistry may be of help if sufficient material is provided. To avoid false positive diagnosis on cytology, it is best to report such a case as intermediate (atypical/suspicious) with final interpretation pending excisional biopsy. SN - 1221-9118 UR - https://www.unboundmedicine.com/medline/citation/18457104/Fibroadenoma_masquerading_carcinoma_on_fine_needle_aspiration_of_the_breast_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -