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[Effects of glutamine enriched enteral feeding on immunoregulation in burn patients].
Zhonghua Shao Shang Za Zhi. 2007 Dec; 23(6):406-8.ZS

Abstract

OBJECTIVE

To investigate the effects of glutamine enriched enteral feeding on immunoregulation in burn patients.

METHODS

Twenty burn patients were randomly divided into enteral nutrition (EN) group and enteral immune nutrition (EIN) group, with 12 patients in each group. Patients in EN group received a standard enteral formula, while those in EIN group received an enteral formula enriched with glutamine after hospital admission. Nutritional support was continued for 10 days. Blood samples were obtained to determine plasma level of total protein (TP), albumin (ALB), prealbumin (PAB) and transferrin (TF) at 1, 4, 7, 10 post-burn days (PBD). At the same time the concentration of immunoglobulin (IgA, IgG and IgM) were determined, the percentage of CD3+, CD4+, CD8+ subpopulations of T lymphocytes, and the ratio of CD4+/CD8+ were determined by FCM.

RESULTS

(1) There were no obvious difference of the plasma level of TP, ALB, TF, CD3+, IgM between the two groups at each time-point (P > 0.05). (2) The plasma PAB contents in EIN group were significant higher than that in EN group on 4 PBD [(90 +/- 14 vs 60 +/- 15) mg/L, P < 0.05], 7 PBD [(92 +/- 16 vs 64 +/- 13) mg/L, P < 0.05] and 10 PBD [(106 +/- 21 vs 72 +/-16) mg/L, P < 0.05]. (3) The percentage of CD4+ subpopulation and ratio of CD4+/CD8+ in EIN group were obviously higher than those in EN group on 7 PBD [CD4+ (55 +/- 5 vs 45 +/- 5)%, CD4+/CD8+ (1.92 +/- 0.31 vs 1.53 +/- 0.27)%, P < 0.05] and 10 PBD [CD4+ (56 +/- 5 vs 49 +/- 5)%, CD4+/CD8+ (2.36 +/- 0.36 vs 1.72 +/- 0.42), P < 0.05]. (4) The concentration of IgA and IgG in EIN group were markedly higher than that in EN group on 7 PBD [IgA (2.8 +/- 0.6 vs 2.2 +/- 0.5) g/L, IgG (12.1 +/- 1.3 vs 9.8 +/- 1.2) g/L, P < 0.05] and 10 PBD [IgA (3.1 +/- 0.6 vs 2.5 +/- 0.5) g/L, IgG (14.2 +/- 1.3 vs 10.4 +/- 1.3) g/L, P < 0.05].

CONCLUSION

These findings suggest that glutamine enriched enteral feeding can improve nutritional status by promoting the synthesis of IgA, IgG, and increasing the PAB concentration, and corrected immunologic dysfunction in burn patients.

Authors+Show Affiliations

Guo GH
Department of Burns, First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China.
Deng ZY
No affiliation info available
Wang YX
No affiliation info available
Xing JJ
No affiliation info available
Peng Y
No affiliation info available
Li GH
No affiliation info available

MeSH

AdolescentAdultBurnsEnteral NutritionFemaleGlutamineHumansImmunoglobulin AImmunoglobulin GMaleMiddle AgedPrealbuminT-Lymphocyte SubsetsYoung Adult

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18457248

Citation

Guo, Guang-Hua, et al. "[Effects of Glutamine Enriched Enteral Feeding On Immunoregulation in Burn Patients]." Zhonghua Shao Shang Za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns, vol. 23, no. 6, 2007, pp. 406-8.
Guo GH, Deng ZY, Wang YX, et al. [Effects of glutamine enriched enteral feeding on immunoregulation in burn patients]. Zhonghua Shao Shang Za Zhi. 2007;23(6):406-8.
Guo, G. H., Deng, Z. Y., Wang, Y. X., Xing, J. J., Peng, Y., & Li, G. H. (2007). [Effects of glutamine enriched enteral feeding on immunoregulation in burn patients]. Zhonghua Shao Shang Za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns, 23(6), 406-8.
Guo GH, et al. [Effects of Glutamine Enriched Enteral Feeding On Immunoregulation in Burn Patients]. Zhonghua Shao Shang Za Zhi. 2007;23(6):406-8. PubMed PMID: 18457248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of glutamine enriched enteral feeding on immunoregulation in burn patients]. AU - Guo,Guang-Hua, AU - Deng,Zhi-Yun, AU - Wang,Yan-Xia, AU - Xing,Juan-Juan, AU - Peng,Yan, AU - Li,Guo-Hui, PY - 2008/5/7/pubmed PY - 2009/7/8/medline PY - 2008/5/7/entrez SP - 406 EP - 8 JF - Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns JO - Zhonghua Shao Shang Za Zhi VL - 23 IS - 6 N2 - OBJECTIVE: To investigate the effects of glutamine enriched enteral feeding on immunoregulation in burn patients. METHODS: Twenty burn patients were randomly divided into enteral nutrition (EN) group and enteral immune nutrition (EIN) group, with 12 patients in each group. Patients in EN group received a standard enteral formula, while those in EIN group received an enteral formula enriched with glutamine after hospital admission. Nutritional support was continued for 10 days. Blood samples were obtained to determine plasma level of total protein (TP), albumin (ALB), prealbumin (PAB) and transferrin (TF) at 1, 4, 7, 10 post-burn days (PBD). At the same time the concentration of immunoglobulin (IgA, IgG and IgM) were determined, the percentage of CD3+, CD4+, CD8+ subpopulations of T lymphocytes, and the ratio of CD4+/CD8+ were determined by FCM. RESULTS: (1) There were no obvious difference of the plasma level of TP, ALB, TF, CD3+, IgM between the two groups at each time-point (P > 0.05). (2) The plasma PAB contents in EIN group were significant higher than that in EN group on 4 PBD [(90 +/- 14 vs 60 +/- 15) mg/L, P < 0.05], 7 PBD [(92 +/- 16 vs 64 +/- 13) mg/L, P < 0.05] and 10 PBD [(106 +/- 21 vs 72 +/-16) mg/L, P < 0.05]. (3) The percentage of CD4+ subpopulation and ratio of CD4+/CD8+ in EIN group were obviously higher than those in EN group on 7 PBD [CD4+ (55 +/- 5 vs 45 +/- 5)%, CD4+/CD8+ (1.92 +/- 0.31 vs 1.53 +/- 0.27)%, P < 0.05] and 10 PBD [CD4+ (56 +/- 5 vs 49 +/- 5)%, CD4+/CD8+ (2.36 +/- 0.36 vs 1.72 +/- 0.42), P < 0.05]. (4) The concentration of IgA and IgG in EIN group were markedly higher than that in EN group on 7 PBD [IgA (2.8 +/- 0.6 vs 2.2 +/- 0.5) g/L, IgG (12.1 +/- 1.3 vs 9.8 +/- 1.2) g/L, P < 0.05] and 10 PBD [IgA (3.1 +/- 0.6 vs 2.5 +/- 0.5) g/L, IgG (14.2 +/- 1.3 vs 10.4 +/- 1.3) g/L, P < 0.05]. CONCLUSION: These findings suggest that glutamine enriched enteral feeding can improve nutritional status by promoting the synthesis of IgA, IgG, and increasing the PAB concentration, and corrected immunologic dysfunction in burn patients. SN - 1009-2587 UR - https://www.unboundmedicine.com/medline/citation/18457248/[Effects_of_glutamine_enriched_enteral_feeding_on_immunoregulation_in_burn_patients]_ DB - PRIME DP - Unbound Medicine ER -