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Translational imaging studies of cortical spreading depression in experimental models for migraine aura.
Expert Rev Neurother 2008; 8(5):759-68ER

Abstract

This perspective discusses cortical spreading depression (CSD) phenomena and their translational significance for human migraine aura and the peri-infarct events following cerebral ischemia and injury. They begin with interstitial K(+) release and accumulation following neuronal stimulation, and a buffering astrocytic K(+) influx and remote liberation propagating waves of neuronal hyperexcitability and depression. Diffusion-weighted echoplanar MRI demonstrates CSD features in gyrencephalic brains recapitulating human migraine aura, spatial and temporal features of single primary events and multiple secondary events, their stimulus dependence, pharmacological properties, and their relationship to blood oxygenation level-dependent signals and late cerebrovascular changes. The article finally explores prospects for physiological studies of CSD gaining fuller insights both into mechanisms underlying the pathology of the corresponding human condition and possible approaches to management.

Authors+Show Affiliations

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. justin@justin-smith.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18457533

Citation

Smith, Justin M., et al. "Translational Imaging Studies of Cortical Spreading Depression in Experimental Models for Migraine Aura." Expert Review of Neurotherapeutics, vol. 8, no. 5, 2008, pp. 759-68.
Smith JM, James MF, Fraser JA, et al. Translational imaging studies of cortical spreading depression in experimental models for migraine aura. Expert Rev Neurother. 2008;8(5):759-68.
Smith, J. M., James, M. F., Fraser, J. A., & Huang, C. L. (2008). Translational imaging studies of cortical spreading depression in experimental models for migraine aura. Expert Review of Neurotherapeutics, 8(5), pp. 759-68. doi:10.1586/14737175.8.5.759.
Smith JM, et al. Translational Imaging Studies of Cortical Spreading Depression in Experimental Models for Migraine Aura. Expert Rev Neurother. 2008;8(5):759-68. PubMed PMID: 18457533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Translational imaging studies of cortical spreading depression in experimental models for migraine aura. AU - Smith,Justin M, AU - James,Michael F, AU - Fraser,James A, AU - Huang,Christopher L-H, PY - 2008/5/7/pubmed PY - 2008/6/5/medline PY - 2008/5/7/entrez SP - 759 EP - 68 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 8 IS - 5 N2 - This perspective discusses cortical spreading depression (CSD) phenomena and their translational significance for human migraine aura and the peri-infarct events following cerebral ischemia and injury. They begin with interstitial K(+) release and accumulation following neuronal stimulation, and a buffering astrocytic K(+) influx and remote liberation propagating waves of neuronal hyperexcitability and depression. Diffusion-weighted echoplanar MRI demonstrates CSD features in gyrencephalic brains recapitulating human migraine aura, spatial and temporal features of single primary events and multiple secondary events, their stimulus dependence, pharmacological properties, and their relationship to blood oxygenation level-dependent signals and late cerebrovascular changes. The article finally explores prospects for physiological studies of CSD gaining fuller insights both into mechanisms underlying the pathology of the corresponding human condition and possible approaches to management. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/18457533/Translational_imaging_studies_of_cortical_spreading_depression_in_experimental_models_for_migraine_aura_ L2 - http://www.tandfonline.com/doi/full/10.1586/14737175.8.5.759 DB - PRIME DP - Unbound Medicine ER -