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Potential therapeutic role of statins in neurological disorders.
Expert Rev Neurother 2008; 8(5):827-37ER

Abstract

Statins, the inhibitors of HMG-CoA reductase, are currently among the most commonly prescribed agents for the prevention of cardiovascular disease. It is well established that statins reduce cholesterol levels and prevent coronary heart disease. Moreover, evidence suggests that statins have additional properties such as endothelial protection via actions on the nitric oxide synthetase system as well as antioxidant, anti-inflammatory and antiplatelet effects. There is evidence that all these actions might have potential therapeutic implications not only in stroke, but also in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and primary brain tumors. In this review, we summarize the protective effects of statins on various neurological diseases. Currently available data suggest that statins are safe and effective in the treatment of these neurological disorders, although further experiments and new data are required.

Authors+Show Affiliations

Dipartimento di Scienze Farmaceutiche, University di Salerno, Via Ponte Don Melillo 84084 Fisciano, Salerno, Italy. maubiful@unisa.it

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18457539

Citation

Bifulco, Maurizio, et al. "Potential Therapeutic Role of Statins in Neurological Disorders." Expert Review of Neurotherapeutics, vol. 8, no. 5, 2008, pp. 827-37.
Bifulco M, Malfitano AM, Marasco G. Potential therapeutic role of statins in neurological disorders. Expert Rev Neurother. 2008;8(5):827-37.
Bifulco, M., Malfitano, A. M., & Marasco, G. (2008). Potential therapeutic role of statins in neurological disorders. Expert Review of Neurotherapeutics, 8(5), pp. 827-37. doi:10.1586/14737175.8.5.827.
Bifulco M, Malfitano AM, Marasco G. Potential Therapeutic Role of Statins in Neurological Disorders. Expert Rev Neurother. 2008;8(5):827-37. PubMed PMID: 18457539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential therapeutic role of statins in neurological disorders. AU - Bifulco,Maurizio, AU - Malfitano,Anna Maria, AU - Marasco,Giuseppe, PY - 2008/5/7/pubmed PY - 2008/6/5/medline PY - 2008/5/7/entrez SP - 827 EP - 37 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 8 IS - 5 N2 - Statins, the inhibitors of HMG-CoA reductase, are currently among the most commonly prescribed agents for the prevention of cardiovascular disease. It is well established that statins reduce cholesterol levels and prevent coronary heart disease. Moreover, evidence suggests that statins have additional properties such as endothelial protection via actions on the nitric oxide synthetase system as well as antioxidant, anti-inflammatory and antiplatelet effects. There is evidence that all these actions might have potential therapeutic implications not only in stroke, but also in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and primary brain tumors. In this review, we summarize the protective effects of statins on various neurological diseases. Currently available data suggest that statins are safe and effective in the treatment of these neurological disorders, although further experiments and new data are required. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/18457539/Potential_therapeutic_role_of_statins_in_neurological_disorders_ L2 - http://www.tandfonline.com/doi/full/10.1586/14737175.8.5.827 DB - PRIME DP - Unbound Medicine ER -