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Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems.
Eur J Pharmacol. 2008 Jun 10; 587(1-3):163-8.EJ

Abstract

We have recently shown that the hexanic extract from leaves of Schinus molle produces antidepressant-like effects in the tail suspension test in mice. This study investigated the antidepressant-like effect of the ethanolic extract from aerial part of S. molle in the forced swimming test and tail suspension test in mice, two predictive models of depression. Moreover, we investigated the antidepressant potential of rutin, a flavonoid isolated from the ethanolic extract of this plant and the influence of the pretreatment with the inhibitors of serotonin or noradrenaline synthesis, p-chlorophenylalanine methyl ester (PCPA) and alpha-methyl-p-tyrosine (AMPT), respectively in the antidepressant-like effect of this flavonoid. The administration of the ethanolic extract produced a reduction in the immobility time in the tail suspension test (dose range 600-1000 mg/kg, p.o.), but not in the forced swimming test. It also produced a reduction in the ambulation in the open-field test in mice not previously habituated to the arena, but no effect in the locomotor activity in mice previously habituated to the open-field. The administration of rutin reduced the immobility time in the tail suspension test (0.3-3 mg/kg, p.o.), but not in the forced swimming test, without producing alteration in the locomotor activity. In addition, pretreatment of mice with PCPA (100 mg/kg, i.p., for 4 consecutive days) or AMPT (100 mg/kg, i.p.) prevented the anti-immobility effect of rutin (0.3 mg/kg, p.o.) in the tail suspension test. The results firstly indicated the antidepressant-like effect of the ethanolic extract of S. molle in the tail suspension test may be dependent on the presence of rutin that likely exerts its antidepressant-like effect by increasing the availability of serotonin and noradrenaline in the synaptic cleft.

Authors+Show Affiliations

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, 88040-900, Florianópolis-SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18457827

Citation

Machado, Daniele G., et al. "Antidepressant-like Effect of Rutin Isolated From the Ethanolic Extract From Schinus Molle L. in Mice: Evidence for the Involvement of the Serotonergic and Noradrenergic Systems." European Journal of Pharmacology, vol. 587, no. 1-3, 2008, pp. 163-8.
Machado DG, Bettio LE, Cunha MP, et al. Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Eur J Pharmacol. 2008;587(1-3):163-8.
Machado, D. G., Bettio, L. E., Cunha, M. P., Santos, A. R., Pizzolatti, M. G., Brighente, I. M., & Rodrigues, A. L. (2008). Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems. European Journal of Pharmacology, 587(1-3), 163-8. https://doi.org/10.1016/j.ejphar.2008.03.021
Machado DG, et al. Antidepressant-like Effect of Rutin Isolated From the Ethanolic Extract From Schinus Molle L. in Mice: Evidence for the Involvement of the Serotonergic and Noradrenergic Systems. Eur J Pharmacol. 2008 Jun 10;587(1-3):163-8. PubMed PMID: 18457827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems. AU - Machado,Daniele G, AU - Bettio,Luis E B, AU - Cunha,Mauricio P, AU - Santos,Adair R S, AU - Pizzolatti,Moacir G, AU - Brighente,Inês M C, AU - Rodrigues,Ana Lúcia S, Y1 - 2008/03/29/ PY - 2007/09/21/received PY - 2008/02/21/revised PY - 2008/03/03/accepted PY - 2008/5/7/pubmed PY - 2008/8/30/medline PY - 2008/5/7/entrez SP - 163 EP - 8 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 587 IS - 1-3 N2 - We have recently shown that the hexanic extract from leaves of Schinus molle produces antidepressant-like effects in the tail suspension test in mice. This study investigated the antidepressant-like effect of the ethanolic extract from aerial part of S. molle in the forced swimming test and tail suspension test in mice, two predictive models of depression. Moreover, we investigated the antidepressant potential of rutin, a flavonoid isolated from the ethanolic extract of this plant and the influence of the pretreatment with the inhibitors of serotonin or noradrenaline synthesis, p-chlorophenylalanine methyl ester (PCPA) and alpha-methyl-p-tyrosine (AMPT), respectively in the antidepressant-like effect of this flavonoid. The administration of the ethanolic extract produced a reduction in the immobility time in the tail suspension test (dose range 600-1000 mg/kg, p.o.), but not in the forced swimming test. It also produced a reduction in the ambulation in the open-field test in mice not previously habituated to the arena, but no effect in the locomotor activity in mice previously habituated to the open-field. The administration of rutin reduced the immobility time in the tail suspension test (0.3-3 mg/kg, p.o.), but not in the forced swimming test, without producing alteration in the locomotor activity. In addition, pretreatment of mice with PCPA (100 mg/kg, i.p., for 4 consecutive days) or AMPT (100 mg/kg, i.p.) prevented the anti-immobility effect of rutin (0.3 mg/kg, p.o.) in the tail suspension test. The results firstly indicated the antidepressant-like effect of the ethanolic extract of S. molle in the tail suspension test may be dependent on the presence of rutin that likely exerts its antidepressant-like effect by increasing the availability of serotonin and noradrenaline in the synaptic cleft. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/18457827/Antidepressant_like_effect_of_rutin_isolated_from_the_ethanolic_extract_from_Schinus_molle_L__in_mice:_evidence_for_the_involvement_of_the_serotonergic_and_noradrenergic_systems_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(08)00358-0 DB - PRIME DP - Unbound Medicine ER -