Tags

Type your tag names separated by a space and hit enter

A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death.
Neurobiol Aging. 2010 Jan; 31(1):99-103.NA

Abstract

Lewy bodies in Parkinson disease could be innocent bystanders or active agents responsible for neuronal death. Eighteen elderly patients with a Parkinson syndrome were studied prospectively and selected postmortem on the presence of Lewy bodies (14 cases with Parkinson disease, four with dementia with Lewy bodies). Information on disease duration was available in 17 cases. While akinesia and rigidity were linked with the neuronal loss, the percentages of Lewy body bearing neurons and of alpha-synuclein immunoreactive neurons in the substantia nigra were not correlated with the symptoms or the disease duration, and appeared stable, involving 3.6% of the neurons on average. Such stability indicated that, during the whole course of the disease, the destruction of the Lewy bodies was equal to their production. In the model that is proposed here, the Lewy bodies are eliminated when the neurons that bear them die. With the hypothesis that neuronal death is directly related to Lewy bodies, it is possible to estimate their life span, which was calculated to be 6.2 months (15.9 months for any type of alpha-synuclein inclusion).

Authors+Show Affiliations

Geriatrics Centre, Pavillon M Bottard, La Salpetriere Hospital, Pierre & Marie Curie (Paris VI) University, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18457903

Citation

Greffard, Sandrine, et al. "A Stable Proportion of Lewy Body Bearing Neurons in the Substantia Nigra Suggests a Model in Which the Lewy Body Causes Neuronal Death." Neurobiology of Aging, vol. 31, no. 1, 2010, pp. 99-103.
Greffard S, Verny M, Bonnet AM, et al. A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death. Neurobiol Aging. 2010;31(1):99-103.
Greffard, S., Verny, M., Bonnet, A. M., Seilhean, D., Hauw, J. J., & Duyckaerts, C. (2010). A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death. Neurobiology of Aging, 31(1), 99-103. https://doi.org/10.1016/j.neurobiolaging.2008.03.015
Greffard S, et al. A Stable Proportion of Lewy Body Bearing Neurons in the Substantia Nigra Suggests a Model in Which the Lewy Body Causes Neuronal Death. Neurobiol Aging. 2010;31(1):99-103. PubMed PMID: 18457903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death. AU - Greffard,Sandrine, AU - Verny,Marc, AU - Bonnet,Anne-Marie, AU - Seilhean,Danielle, AU - Hauw,Jean-Jacques, AU - Duyckaerts,Charles, Y1 - 2008/05/23/ PY - 2007/06/16/received PY - 2008/02/27/revised PY - 2008/03/20/accepted PY - 2008/5/7/pubmed PY - 2010/7/9/medline PY - 2008/5/7/entrez SP - 99 EP - 103 JF - Neurobiology of aging JO - Neurobiol Aging VL - 31 IS - 1 N2 - Lewy bodies in Parkinson disease could be innocent bystanders or active agents responsible for neuronal death. Eighteen elderly patients with a Parkinson syndrome were studied prospectively and selected postmortem on the presence of Lewy bodies (14 cases with Parkinson disease, four with dementia with Lewy bodies). Information on disease duration was available in 17 cases. While akinesia and rigidity were linked with the neuronal loss, the percentages of Lewy body bearing neurons and of alpha-synuclein immunoreactive neurons in the substantia nigra were not correlated with the symptoms or the disease duration, and appeared stable, involving 3.6% of the neurons on average. Such stability indicated that, during the whole course of the disease, the destruction of the Lewy bodies was equal to their production. In the model that is proposed here, the Lewy bodies are eliminated when the neurons that bear them die. With the hypothesis that neuronal death is directly related to Lewy bodies, it is possible to estimate their life span, which was calculated to be 6.2 months (15.9 months for any type of alpha-synuclein inclusion). SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/18457903/A_stable_proportion_of_Lewy_body_bearing_neurons_in_the_substantia_nigra_suggests_a_model_in_which_the_Lewy_body_causes_neuronal_death_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(08)00102-4 DB - PRIME DP - Unbound Medicine ER -