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Knee height and arm span: a reflection of early life environment and risk of dementia.
Neurology. 2008 May 06; 70(19 Pt 2):1818-26.Neur

Abstract

OBJECTIVES

To determine if anthropometric measures, as markers of early life environment, are associated with risk of dementia, Alzheimer disease (AD), and vascular dementia (VaD).

METHODS

A total of 2,798 subjects were followed as part of the Cardiovascular Health Cognition Study for an average of 5.4 years; 480 developed dementia. Knee height was measured 3 years prior to and arm span 4 years after the study's baseline. Cox proportional hazard models were used to examine their association with subsequent risk of dementia, AD, and VaD.

RESULTS

Among women, greater knee height and arm span were associated with lower risks of dementia (knee height: HR per 1-inch increase 0.84; 95% CI 0.74-0.96; arm span: HR per 1-inch increase 0.93; 95% CI 0.88-0.98) and AD (knee height: HR per 1-inch increase 0.78; 95% CI 0.65-0.93; arm span: HR per 1-inch increase 0.90; 95% CI 0.85-0.96). Women in the lowest quartile of arm span had approximately 1.5 times greater risk of dementia (HR 1.45; 95% CI 1.03-2.05) and AD (HR 1.70; 95% CI 1.10-2.62) than other women. Among men, only arm span was associated with lower risks of dementia (HR per 1-inch increase 0.94; 95% CI 0.89-1.00) and AD (HR per 1-inch increase 0.92; 95% CI 0.84-1.00). For each gender, knee height was not associated with VaD, while arm span was associated with a nonsignificant lower risk of VaD.

CONCLUSIONS

Our findings with knee height and arm span are consistent with previous reports and suggest early life environment may play an important role in the determination of future dementia risk.

Authors+Show Affiliations

Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. tina.huang@tufts.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18458216

Citation

Huang, T L., et al. "Knee Height and Arm Span: a Reflection of Early Life Environment and Risk of Dementia." Neurology, vol. 70, no. 19 Pt 2, 2008, pp. 1818-26.
Huang TL, Carlson MC, Fitzpatrick AL, et al. Knee height and arm span: a reflection of early life environment and risk of dementia. Neurology. 2008;70(19 Pt 2):1818-26.
Huang, T. L., Carlson, M. C., Fitzpatrick, A. L., Kuller, L. H., Fried, L. P., & Zandi, P. P. (2008). Knee height and arm span: a reflection of early life environment and risk of dementia. Neurology, 70(19 Pt 2), 1818-26. https://doi.org/10.1212/01.wnl.0000311444.20490.98
Huang TL, et al. Knee Height and Arm Span: a Reflection of Early Life Environment and Risk of Dementia. Neurology. 2008 May 6;70(19 Pt 2):1818-26. PubMed PMID: 18458216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Knee height and arm span: a reflection of early life environment and risk of dementia. AU - Huang,T L, AU - Carlson,M C, AU - Fitzpatrick,A L, AU - Kuller,L H, AU - Fried,L P, AU - Zandi,P P, PY - 2008/5/7/pubmed PY - 2008/6/7/medline PY - 2008/5/7/entrez SP - 1818 EP - 26 JF - Neurology JO - Neurology VL - 70 IS - 19 Pt 2 N2 - OBJECTIVES: To determine if anthropometric measures, as markers of early life environment, are associated with risk of dementia, Alzheimer disease (AD), and vascular dementia (VaD). METHODS: A total of 2,798 subjects were followed as part of the Cardiovascular Health Cognition Study for an average of 5.4 years; 480 developed dementia. Knee height was measured 3 years prior to and arm span 4 years after the study's baseline. Cox proportional hazard models were used to examine their association with subsequent risk of dementia, AD, and VaD. RESULTS: Among women, greater knee height and arm span were associated with lower risks of dementia (knee height: HR per 1-inch increase 0.84; 95% CI 0.74-0.96; arm span: HR per 1-inch increase 0.93; 95% CI 0.88-0.98) and AD (knee height: HR per 1-inch increase 0.78; 95% CI 0.65-0.93; arm span: HR per 1-inch increase 0.90; 95% CI 0.85-0.96). Women in the lowest quartile of arm span had approximately 1.5 times greater risk of dementia (HR 1.45; 95% CI 1.03-2.05) and AD (HR 1.70; 95% CI 1.10-2.62) than other women. Among men, only arm span was associated with lower risks of dementia (HR per 1-inch increase 0.94; 95% CI 0.89-1.00) and AD (HR per 1-inch increase 0.92; 95% CI 0.84-1.00). For each gender, knee height was not associated with VaD, while arm span was associated with a nonsignificant lower risk of VaD. CONCLUSIONS: Our findings with knee height and arm span are consistent with previous reports and suggest early life environment may play an important role in the determination of future dementia risk. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/18458216/Knee_height_and_arm_span:_a_reflection_of_early_life_environment_and_risk_of_dementia_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=18458216 DB - PRIME DP - Unbound Medicine ER -