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Human red blood cells deformed under thermal fluid flow.
Biomed Mater 2006; 1(1):1-7BM

Abstract

The flow-induced mechanical deformation of a human red blood cell (RBC) during thermal transition between room temperature and 42.0 degrees C is interrogated by laser tweezer experiments. Based on the experimental geometry of the deformed RBC, the surface stresses are determined with the aid of computational fluid dynamics simulation. It is found that the RBC is more deformable while heating through 37.0 degrees C to 42.0 degrees C, especially at a higher flow velocity due to a thermal-fluid effect. More importantly, the degree of RBC deformation is irreversible and becomes softer, and finally reaches a plateau (at a uniform flow velocity U > 60 microm s(-1)) after the heat treatment, which is similar to a strain-hardening dominated process. In addition, computational simulated stress is found to be dependent on the progression of thermotropic phase transition. Overall, the current study provides new insights into the highly coupled temperature and hydrodynamic effects on the biomechanical properties of human erythrocyte in a model hydrodynamic flow system.

Authors+Show Affiliations

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, 01307 Dresden, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18458379

Citation

Foo, Ji-Jinn, et al. "Human Red Blood Cells Deformed Under Thermal Fluid Flow." Biomedical Materials (Bristol, England), vol. 1, no. 1, 2006, pp. 1-7.
Foo JJ, Chan V, Feng ZQ, et al. Human red blood cells deformed under thermal fluid flow. Biomed Mater. 2006;1(1):1-7.
Foo, J. J., Chan, V., Feng, Z. Q., & Liu, K. K. (2006). Human red blood cells deformed under thermal fluid flow. Biomedical Materials (Bristol, England), 1(1), pp. 1-7. doi:10.1088/1748-6041/1/1/001.
Foo JJ, et al. Human Red Blood Cells Deformed Under Thermal Fluid Flow. Biomed Mater. 2006;1(1):1-7. PubMed PMID: 18458379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human red blood cells deformed under thermal fluid flow. AU - Foo,Ji-Jinn, AU - Chan,Vincent, AU - Feng,Zhi-Qin, AU - Liu,Kuo-Kang, Y1 - 2006/03/01/ PY - 2008/5/7/pubmed PY - 2008/5/29/medline PY - 2008/5/7/entrez SP - 1 EP - 7 JF - Biomedical materials (Bristol, England) JO - Biomed Mater VL - 1 IS - 1 N2 - The flow-induced mechanical deformation of a human red blood cell (RBC) during thermal transition between room temperature and 42.0 degrees C is interrogated by laser tweezer experiments. Based on the experimental geometry of the deformed RBC, the surface stresses are determined with the aid of computational fluid dynamics simulation. It is found that the RBC is more deformable while heating through 37.0 degrees C to 42.0 degrees C, especially at a higher flow velocity due to a thermal-fluid effect. More importantly, the degree of RBC deformation is irreversible and becomes softer, and finally reaches a plateau (at a uniform flow velocity U > 60 microm s(-1)) after the heat treatment, which is similar to a strain-hardening dominated process. In addition, computational simulated stress is found to be dependent on the progression of thermotropic phase transition. Overall, the current study provides new insights into the highly coupled temperature and hydrodynamic effects on the biomechanical properties of human erythrocyte in a model hydrodynamic flow system. SN - 1748-605X UR - https://www.unboundmedicine.com/medline/citation/18458379/Human_red_blood_cells_deformed_under_thermal_fluid_flow_ L2 - https://doi.org/10.1088/1748-6041/1/1/001 DB - PRIME DP - Unbound Medicine ER -