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Effects of THC on driving performance, physiological state and subjective feelings relative to alcohol.
Accid Anal Prev. 2008 May; 40(3):926-34.AA

Abstract

BACKGROUND

The effects of marijuana or THC on driving has been tested in several studies, but usually not in conjunction with physiological and subjective responses and not in comparison to alcohol effects on all three types of measures.

OBJECTIVE

To assess the effects of two dosages of THC relative to alcohol on driving performance, physiological strain, and subjective feelings.

METHOD

We tested the subjective feelings and driving abilities after placebo, smoking two dosages of THC (13 mg and 17 mg), drinking (0.05% BAC) and 24 h after smoking the high dose THC cigarette, while monitoring physiological activity of the drugs by heart rate. Fourteen healthy students, all recreational marijuana users, participated in the study.

RESULTS

Both levels of THC cigarettes significantly affected the subjects in a dose-dependent manner. The moderate dose of alcohol and the low THC dose were equally detrimental to some of the driving abilities, with some differences between the two drugs. THC primarily caused elevation in physical effort and physical discomfort during the drive while alcohol tended to affect sleepiness level. After THC administration, subjects drove significantly slower than in the control condition, while after alcohol ingestion, subjects drove significantly faster than in the control condition. No THC effects were observed after 24 h on any of the measures.

Authors+Show Affiliations

Work Physiology, Human Factors and Traffic Safety, Department of Industrial Engineering and Management, Ben Gurion University of the Negev, Beer Sheva, Israel. adiro@bgu.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18460360

Citation

Ronen, Adi, et al. "Effects of THC On Driving Performance, Physiological State and Subjective Feelings Relative to Alcohol." Accident; Analysis and Prevention, vol. 40, no. 3, 2008, pp. 926-34.
Ronen A, Gershon P, Drobiner H, et al. Effects of THC on driving performance, physiological state and subjective feelings relative to alcohol. Accid Anal Prev. 2008;40(3):926-34.
Ronen, A., Gershon, P., Drobiner, H., Rabinovich, A., Bar-Hamburger, R., Mechoulam, R., Cassuto, Y., & Shinar, D. (2008). Effects of THC on driving performance, physiological state and subjective feelings relative to alcohol. Accident; Analysis and Prevention, 40(3), 926-34. https://doi.org/10.1016/j.aap.2007.10.011
Ronen A, et al. Effects of THC On Driving Performance, Physiological State and Subjective Feelings Relative to Alcohol. Accid Anal Prev. 2008;40(3):926-34. PubMed PMID: 18460360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of THC on driving performance, physiological state and subjective feelings relative to alcohol. AU - Ronen,Adi, AU - Gershon,Pnina, AU - Drobiner,Hanan, AU - Rabinovich,Alex, AU - Bar-Hamburger,Rachel, AU - Mechoulam,Raphael, AU - Cassuto,Yair, AU - Shinar,David, Y1 - 2007/11/26/ PY - 2007/03/07/received PY - 2007/10/20/revised PY - 2007/10/29/accepted PY - 2008/5/8/pubmed PY - 2008/9/27/medline PY - 2008/5/8/entrez SP - 926 EP - 34 JF - Accident; analysis and prevention JO - Accid Anal Prev VL - 40 IS - 3 N2 - BACKGROUND: The effects of marijuana or THC on driving has been tested in several studies, but usually not in conjunction with physiological and subjective responses and not in comparison to alcohol effects on all three types of measures. OBJECTIVE: To assess the effects of two dosages of THC relative to alcohol on driving performance, physiological strain, and subjective feelings. METHOD: We tested the subjective feelings and driving abilities after placebo, smoking two dosages of THC (13 mg and 17 mg), drinking (0.05% BAC) and 24 h after smoking the high dose THC cigarette, while monitoring physiological activity of the drugs by heart rate. Fourteen healthy students, all recreational marijuana users, participated in the study. RESULTS: Both levels of THC cigarettes significantly affected the subjects in a dose-dependent manner. The moderate dose of alcohol and the low THC dose were equally detrimental to some of the driving abilities, with some differences between the two drugs. THC primarily caused elevation in physical effort and physical discomfort during the drive while alcohol tended to affect sleepiness level. After THC administration, subjects drove significantly slower than in the control condition, while after alcohol ingestion, subjects drove significantly faster than in the control condition. No THC effects were observed after 24 h on any of the measures. SN - 0001-4575 UR - https://www.unboundmedicine.com/medline/citation/18460360/Effects_of_THC_on_driving_performance_physiological_state_and_subjective_feelings_relative_to_alcohol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-4575(07)00193-5 DB - PRIME DP - Unbound Medicine ER -