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Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
J Am Coll Nutr. 2008 Feb; 27(1):127-36.JA

Abstract

OBJECTIVE

To investigate the association of dietary folate, vitamin B(6) (VB(6)) and vitamin B(12) (VB(12)) with the risk of coronary heart disease among middle-aged persons.

METHODS

A total of 40,803 subjects aged 40-59 years living in the community who were free of prior diagnoses of cardiovascular disease and cancer and who completed a food frequency questionnaire were followed from 1990-1992 to the end of 2001 in the Japan Public Health Center-based Prospective Study.

RESULTS

After 468,472 person-years of follow-up, 251 coronary heart disease incidents were documented. Coronary heart disease and definite myocardial infarction were inversely associated with dietary intake of folate, VB(6) and VB(12) after adjustment for age and sex, but the associations were attenuated after further adjustment for smoking, dietary and other cardiovascular risk factors. However, among non-multivitamin supplement users, multivariable hazard ratios (95% confidence intervals) in the highest vs. lowest quintiles of VB(6) intake were 0.60 (0.37-0.97) for total coronary heart disease and 0.52 (0.29-0.91) for definite myocardial infarction, and the inverse associations with VB(12) were marginally significant. The combination of below-median intake of three vitamins or of only B(6) conferred a twice excess risk of total coronary heart disease.

CONCLUSIONS

Dietary intake of VB(6) was associated with a reduced risk of coronary heart disease among middle-aged non-multivitamin supplement users. Dietary folate and VB(12) were also suggested to be protective factors for coronary heart disease.

Authors+Show Affiliations

Ishihara J
Department of Public Health Medicine, University of Tsukuba, Ibaraki, Japan.
Iso H
No affiliation info available
Inoue M
No affiliation info available
Iwasaki M
No affiliation info available
Okada K
No affiliation info available
Kita Y
No affiliation info available
Kokubo Y
No affiliation info available
Okayama A
No affiliation info available
Tsugane S
No affiliation info available
JPHC Study Group
No affiliation info available

MeSH

AdultCardiovascular DiseasesCohort StudiesConfidence IntervalsDietary SupplementsFemaleFolic AcidFollow-Up StudiesHumansIncidenceJapanMaleMiddle AgedMultivariate AnalysisNutrition SurveysOdds RatioProspective StudiesRisk FactorsSurveys and QuestionnairesVitamin B 12Vitamin B 6Vitamin B Complex

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18460491

Citation

Ishihara, Junko, et al. "Intake of Folate, Vitamin B6 and Vitamin B12 and the Risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I." Journal of the American College of Nutrition, vol. 27, no. 1, 2008, pp. 127-36.
Ishihara J, Iso H, Inoue M, et al. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I. J Am Coll Nutr. 2008;27(1):127-36.
Ishihara, J., Iso, H., Inoue, M., Iwasaki, M., Okada, K., Kita, Y., Kokubo, Y., Okayama, A., & Tsugane, S. (2008). Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I. Journal of the American College of Nutrition, 27(1), 127-36.
Ishihara J, et al. Intake of Folate, Vitamin B6 and Vitamin B12 and the Risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I. J Am Coll Nutr. 2008;27(1):127-36. PubMed PMID: 18460491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I. AU - Ishihara,Junko, AU - Iso,Hiroyasu, AU - Inoue,Manami, AU - Iwasaki,Motoki, AU - Okada,Katsutoshi, AU - Kita,Yoshikuni, AU - Kokubo,Yoshihiro, AU - Okayama,Akira, AU - Tsugane,Shoichiro, AU - ,, PY - 2008/5/8/pubmed PY - 2008/7/4/medline PY - 2008/5/8/entrez SP - 127 EP - 36 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 27 IS - 1 N2 - OBJECTIVE: To investigate the association of dietary folate, vitamin B(6) (VB(6)) and vitamin B(12) (VB(12)) with the risk of coronary heart disease among middle-aged persons. METHODS: A total of 40,803 subjects aged 40-59 years living in the community who were free of prior diagnoses of cardiovascular disease and cancer and who completed a food frequency questionnaire were followed from 1990-1992 to the end of 2001 in the Japan Public Health Center-based Prospective Study. RESULTS: After 468,472 person-years of follow-up, 251 coronary heart disease incidents were documented. Coronary heart disease and definite myocardial infarction were inversely associated with dietary intake of folate, VB(6) and VB(12) after adjustment for age and sex, but the associations were attenuated after further adjustment for smoking, dietary and other cardiovascular risk factors. However, among non-multivitamin supplement users, multivariable hazard ratios (95% confidence intervals) in the highest vs. lowest quintiles of VB(6) intake were 0.60 (0.37-0.97) for total coronary heart disease and 0.52 (0.29-0.91) for definite myocardial infarction, and the inverse associations with VB(12) were marginally significant. The combination of below-median intake of three vitamins or of only B(6) conferred a twice excess risk of total coronary heart disease. CONCLUSIONS: Dietary intake of VB(6) was associated with a reduced risk of coronary heart disease among middle-aged non-multivitamin supplement users. Dietary folate and VB(12) were also suggested to be protective factors for coronary heart disease. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/18460491/Intake_of_folate_vitamin_B6_and_vitamin_B12_and_the_risk_of_CHD:_the_Japan_Public_Health_Center_Based_Prospective_Study_Cohort_I_ DB - PRIME DP - Unbound Medicine ER -