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Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett's oesophagus.
Gut. 2008 Sep; 57(9):1200-6.Gut

Abstract

OBJECTIVE

Endoscopic therapy is increasingly being used in the treatment of high-grade intraepithelial neoplasia (HGIN) and mucosal adenocarcinoma (BC) in patients with Barrett's oesophagus. This report provides 5 year follow-up data from a large prospective study investigating the efficacy and safety of endoscopic treatment in these patients and analysing risk factors for recurrence.

DESIGN

Prospective case series.

SETTING

Academic tertiary care centre.

PATIENTS

Between October 1996 and September 2002, 61 patients with HGIN and 288 with BC were included (173 with short-segment and 176 with long-segment Barrett's oesophagus) from a total of 486 patients presenting with Barrett's neoplasia. Patients with submucosal or more advanced cancer were excluded.

INTERVENTIONS

Endoscopic therapy.

MAIN OUTCOME MEASURES

Rate of complete remission and recurrence rate, tumour-associated death.

RESULTS

Endoscopic resection was performed in 279 patients, photodynamic therapy in 55, and both procedures in 13; two patients received argon plasma coagulation. The mean follow-up period was 63.6 (SD 23.1) months. Complete response (CR) was achieved in 337 patients (96.6%); surgery was necessary in 13 (3.7%) after endoscopic therapy failed. Metachronous lesions developed during the follow-up in 74 patients (21.5%); 56 died of concomitant disease, but none died of BC. The calculated 5 year survival rate was 84%. The risk factors most frequently associated with recurrence were piecemeal resection, long-segment Barrett's oesophagus, no ablative therapy of Barrett's oesophagus after CR, time until CR achieved >10 months and multifocal neoplasia.

CONCLUSIONS

This study showed that endoscopic therapy was highly effective and safe, with an excellent long-term survival rate. The risk factors identified may help stratify patients who are at risk for recurrence and those requiring more intensified follow-up.

Authors+Show Affiliations

Department of Internal Medicine II, HSK Wiesbaden, Ludwig-Erhard-Strasse 100, 65199 Wiesbaden, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

18460553

Citation

Pech, O, et al. "Long-term Results and Risk Factor Analysis for Recurrence After Curative Endoscopic Therapy in 349 Patients With High-grade Intraepithelial Neoplasia and Mucosal Adenocarcinoma in Barrett's Oesophagus." Gut, vol. 57, no. 9, 2008, pp. 1200-6.
Pech O, Behrens A, May A, et al. Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett's oesophagus. Gut. 2008;57(9):1200-6.
Pech, O., Behrens, A., May, A., Nachbar, L., Gossner, L., Rabenstein, T., Manner, H., Guenter, E., Huijsmans, J., Vieth, M., Stolte, M., & Ell, C. (2008). Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett's oesophagus. Gut, 57(9), 1200-6. https://doi.org/10.1136/gut.2007.142539
Pech O, et al. Long-term Results and Risk Factor Analysis for Recurrence After Curative Endoscopic Therapy in 349 Patients With High-grade Intraepithelial Neoplasia and Mucosal Adenocarcinoma in Barrett's Oesophagus. Gut. 2008;57(9):1200-6. PubMed PMID: 18460553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett's oesophagus. AU - Pech,O, AU - Behrens,A, AU - May,A, AU - Nachbar,L, AU - Gossner,L, AU - Rabenstein,T, AU - Manner,H, AU - Guenter,E, AU - Huijsmans,J, AU - Vieth,M, AU - Stolte,M, AU - Ell,C, Y1 - 2008/05/06/ PY - 2008/5/8/pubmed PY - 2008/9/5/medline PY - 2008/5/8/entrez SP - 1200 EP - 6 JF - Gut JO - Gut VL - 57 IS - 9 N2 - OBJECTIVE: Endoscopic therapy is increasingly being used in the treatment of high-grade intraepithelial neoplasia (HGIN) and mucosal adenocarcinoma (BC) in patients with Barrett's oesophagus. This report provides 5 year follow-up data from a large prospective study investigating the efficacy and safety of endoscopic treatment in these patients and analysing risk factors for recurrence. DESIGN: Prospective case series. SETTING: Academic tertiary care centre. PATIENTS: Between October 1996 and September 2002, 61 patients with HGIN and 288 with BC were included (173 with short-segment and 176 with long-segment Barrett's oesophagus) from a total of 486 patients presenting with Barrett's neoplasia. Patients with submucosal or more advanced cancer were excluded. INTERVENTIONS: Endoscopic therapy. MAIN OUTCOME MEASURES: Rate of complete remission and recurrence rate, tumour-associated death. RESULTS: Endoscopic resection was performed in 279 patients, photodynamic therapy in 55, and both procedures in 13; two patients received argon plasma coagulation. The mean follow-up period was 63.6 (SD 23.1) months. Complete response (CR) was achieved in 337 patients (96.6%); surgery was necessary in 13 (3.7%) after endoscopic therapy failed. Metachronous lesions developed during the follow-up in 74 patients (21.5%); 56 died of concomitant disease, but none died of BC. The calculated 5 year survival rate was 84%. The risk factors most frequently associated with recurrence were piecemeal resection, long-segment Barrett's oesophagus, no ablative therapy of Barrett's oesophagus after CR, time until CR achieved >10 months and multifocal neoplasia. CONCLUSIONS: This study showed that endoscopic therapy was highly effective and safe, with an excellent long-term survival rate. The risk factors identified may help stratify patients who are at risk for recurrence and those requiring more intensified follow-up. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/18460553/Long_term_results_and_risk_factor_analysis_for_recurrence_after_curative_endoscopic_therapy_in_349_patients_with_high_grade_intraepithelial_neoplasia_and_mucosal_adenocarcinoma_in_Barrett's_oesophagus_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=18460553 DB - PRIME DP - Unbound Medicine ER -