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Intersphincteric injected silicone biomaterial implants: a treatment for faecal incontinence.
Colorectal Dis. 2009 Jan; 11(1):73-6.CD

Abstract

INTRODUCTION

The aim of this study was to evaluate the functional efficacy of intersphincteric injected silicone biomaterial (PTQ) in patients with faecal incontinence.

METHOD

Prospective study of 33 consecutively included patients (male-female ratio: 9:24); median age 53 years (range: 21-75 years) with faecal incontinence of varied aetiology. The PTQ was injected under general anaesthesia with antibiotic cover. All patients had anorectal manometry, endoanal ultrasonography and responded to faecal incontinence severity questionnaire (Wexner score) and SF-36 short-form health survey questionnaire before and 3 months postoperatively. At time of final follow-up, the continence status and quality of life questionnaire were reassessed.

RESULTS

The mean follow-up was 12.9 months (range: 3-22 months). The Wexner Continence Score was significantly reduced short term from 12.7 to 11.0 (P = 0.03) and long term to 10.4 (P = 0.02). The long-term effect on liquid stool incontinence continued to improve significantly (P < 0.01). Six patients (18%) reported major improvement in Wexner Continence Score at the time of final follow-up. Anorectal manometry was not affected except for the maximum tolerable rectal volume, which was significantly reduced (P < 0.05). The SF-36 short-form questionnaire showed no significant improvement in quality of life after treatment with PTQ.

CONCLUSIONS

Treatment with intersphincteric injection of PTQ implants can provide an improvement in anal continence in patients with faecal incontinence of varied aetiology. However, the improvement is mainly limited to soiling and minor leakage. A majority of patients still have severe incontinence, both short- and long-term.

Authors+Show Affiliations

Surgical Research Unit, Department of Surgery P, Aarhus University Hospital, Aarhus C, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18462216

Citation

Soerensen, M M., et al. "Intersphincteric Injected Silicone Biomaterial Implants: a Treatment for Faecal Incontinence." Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, vol. 11, no. 1, 2009, pp. 73-6.
Soerensen MM, Lundby L, Buntzen S, et al. Intersphincteric injected silicone biomaterial implants: a treatment for faecal incontinence. Colorectal Dis. 2009;11(1):73-6.
Soerensen, M. M., Lundby, L., Buntzen, S., & Laurberg, S. (2009). Intersphincteric injected silicone biomaterial implants: a treatment for faecal incontinence. Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, 11(1), 73-6. https://doi.org/10.1111/j.1463-1318.2008.01544.x
Soerensen MM, et al. Intersphincteric Injected Silicone Biomaterial Implants: a Treatment for Faecal Incontinence. Colorectal Dis. 2009;11(1):73-6. PubMed PMID: 18462216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intersphincteric injected silicone biomaterial implants: a treatment for faecal incontinence. AU - Soerensen,M M, AU - Lundby,L, AU - Buntzen,S, AU - Laurberg,S, Y1 - 2008/04/28/ PY - 2008/5/9/entrez PY - 2008/5/9/pubmed PY - 2009/4/21/medline SP - 73 EP - 6 JF - Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland JO - Colorectal Dis VL - 11 IS - 1 N2 - INTRODUCTION: The aim of this study was to evaluate the functional efficacy of intersphincteric injected silicone biomaterial (PTQ) in patients with faecal incontinence. METHOD: Prospective study of 33 consecutively included patients (male-female ratio: 9:24); median age 53 years (range: 21-75 years) with faecal incontinence of varied aetiology. The PTQ was injected under general anaesthesia with antibiotic cover. All patients had anorectal manometry, endoanal ultrasonography and responded to faecal incontinence severity questionnaire (Wexner score) and SF-36 short-form health survey questionnaire before and 3 months postoperatively. At time of final follow-up, the continence status and quality of life questionnaire were reassessed. RESULTS: The mean follow-up was 12.9 months (range: 3-22 months). The Wexner Continence Score was significantly reduced short term from 12.7 to 11.0 (P = 0.03) and long term to 10.4 (P = 0.02). The long-term effect on liquid stool incontinence continued to improve significantly (P < 0.01). Six patients (18%) reported major improvement in Wexner Continence Score at the time of final follow-up. Anorectal manometry was not affected except for the maximum tolerable rectal volume, which was significantly reduced (P < 0.05). The SF-36 short-form questionnaire showed no significant improvement in quality of life after treatment with PTQ. CONCLUSIONS: Treatment with intersphincteric injection of PTQ implants can provide an improvement in anal continence in patients with faecal incontinence of varied aetiology. However, the improvement is mainly limited to soiling and minor leakage. A majority of patients still have severe incontinence, both short- and long-term. SN - 1463-1318 UR - https://www.unboundmedicine.com/medline/citation/18462216/Intersphincteric_injected_silicone_biomaterial_implants:_a_treatment_for_faecal_incontinence_ L2 - https://doi.org/10.1111/j.1463-1318.2008.01544.x DB - PRIME DP - Unbound Medicine ER -