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Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder.
Int J Urol. 2008 Aug; 15(8):681-7.IJ

Abstract

In the storage phase, mechanical stretch stimulates bladder afferents. These signals generate sensations and trigger voiding responses, however the precise mechanisms by which mechanical stimuli excite bladder afferents are yet to be explored. For mechanosensory transduction, the presence of mechanosensors is essential in the peripheral sensory systems including sensory nerve endings, urothelium and others. There is increasing evidence that mechanosensitive ion channels, such as degenerin/epithelial Na(+) channel (ENaC) and transient receptor potential (TRP) channel families, play key roles in the mechanosensory transduction of the urinary bladder. Pharmacological interventions targeting mechanosensitive ion channels may provide a new strategy for the treatment of bladder dysfunction.

Authors+Show Affiliations

Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Japan. iaraki@yamanashi.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18462357

Citation

Araki, Isao, et al. "Roles of Mechanosensitive Ion Channels in Bladder Sensory Transduction and Overactive Bladder." International Journal of Urology : Official Journal of the Japanese Urological Association, vol. 15, no. 8, 2008, pp. 681-7.
Araki I, Du S, Kobayashi H, et al. Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder. Int J Urol. 2008;15(8):681-7.
Araki, I., Du, S., Kobayashi, H., Sawada, N., Mochizuki, T., Zakoji, H., & Takeda, M. (2008). Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder. International Journal of Urology : Official Journal of the Japanese Urological Association, 15(8), 681-7. https://doi.org/10.1111/j.1442-2042.2008.02052.x
Araki I, et al. Roles of Mechanosensitive Ion Channels in Bladder Sensory Transduction and Overactive Bladder. Int J Urol. 2008;15(8):681-7. PubMed PMID: 18462357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder. AU - Araki,Isao, AU - Du,Shuqi, AU - Kobayashi,Hideki, AU - Sawada,Norifumi, AU - Mochizuki,Tsutomu, AU - Zakoji,Hidenori, AU - Takeda,Masayuki, Y1 - 2008/05/02/ PY - 2008/5/9/pubmed PY - 2008/12/19/medline PY - 2008/5/9/entrez SP - 681 EP - 7 JF - International journal of urology : official journal of the Japanese Urological Association JO - Int J Urol VL - 15 IS - 8 N2 - In the storage phase, mechanical stretch stimulates bladder afferents. These signals generate sensations and trigger voiding responses, however the precise mechanisms by which mechanical stimuli excite bladder afferents are yet to be explored. For mechanosensory transduction, the presence of mechanosensors is essential in the peripheral sensory systems including sensory nerve endings, urothelium and others. There is increasing evidence that mechanosensitive ion channels, such as degenerin/epithelial Na(+) channel (ENaC) and transient receptor potential (TRP) channel families, play key roles in the mechanosensory transduction of the urinary bladder. Pharmacological interventions targeting mechanosensitive ion channels may provide a new strategy for the treatment of bladder dysfunction. SN - 1442-2042 UR - https://www.unboundmedicine.com/medline/citation/18462357/Roles_of_mechanosensitive_ion_channels_in_bladder_sensory_transduction_and_overactive_bladder_ L2 - https://doi.org/10.1111/j.1442-2042.2008.02052.x DB - PRIME DP - Unbound Medicine ER -