Citation
Lee, Do Yeon, et al. "Kynurenic Acid Attenuates MPP(+)-induced Dopaminergic Neuronal Cell Death Via a Bax-mediated Mitochondrial Pathway." European Journal of Cell Biology, vol. 87, no. 6, 2008, pp. 389-97.
Lee DY, Lee KS, Lee HJ, et al. Kynurenic acid attenuates MPP(+)-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway. Eur J Cell Biol. 2008;87(6):389-97.
Lee, D. Y., Lee, K. S., Lee, H. J., Noh, Y. H., Kim, D. H., Lee, J. Y., Cho, S. H., Yoon, O. J., Lee, W. B., Kim, K. Y., Chung, Y. H., & Kim, S. S. (2008). Kynurenic acid attenuates MPP(+)-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway. European Journal of Cell Biology, 87(6), 389-97. https://doi.org/10.1016/j.ejcb.2008.03.003
Lee DY, et al. Kynurenic Acid Attenuates MPP(+)-induced Dopaminergic Neuronal Cell Death Via a Bax-mediated Mitochondrial Pathway. Eur J Cell Biol. 2008;87(6):389-97. PubMed PMID: 18462830.
TY - JOUR
T1 - Kynurenic acid attenuates MPP(+)-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway.
AU - Lee,Do Yeon,
AU - Lee,Kyu-Sun,
AU - Lee,Hyun Jung,
AU - Noh,Yoo Hun,
AU - Kim,Do Hee,
AU - Lee,Jun Young,
AU - Cho,Soo Hyun,
AU - Yoon,Ok Ja,
AU - Lee,Won Bok,
AU - Kim,Kyung Yong,
AU - Chung,Yoon Hee,
AU - Kim,Sung Su,
Y1 - 2008/05/06/
PY - 2007/10/25/received
PY - 2008/03/06/revised
PY - 2008/03/10/accepted
PY - 2008/5/9/pubmed
PY - 2008/9/16/medline
PY - 2008/5/9/entrez
SP - 389
EP - 97
JF - European journal of cell biology
JO - Eur J Cell Biol
VL - 87
IS - 6
N2 - Kynurenic acid (KYNA), a tryptophan metabolite in the kynurenine pathway, is protective against various insults. However, the molecular mechanism of this protective effect has not been identified. In this study, we examined the protective effects of KYNA against 1-methyl-4-phenylpyridinium (MPP(+)), the best-characterized toxin inducing pathological changes resembling Parkinson's disease (PD), using SH-SY5Y and SK-N-SH human neuroblastoma cells. Pre-treatment of KYNA attenuated MPP(+)-induced neuronal cell death in SH-SY5Y and SK-N-SH cells. MPP(+)-induced cell death was preceded by increases in Bax expression and mitochondrial dysfunction, such as collapse of mitochondrial membrane potential (DeltaPsi(m)), release of cytochrome c from mitochondria into the cytoplasm, and increases in caspase-9/-3 activities. KYNA effectively inhibited all of these mitochondrial apoptotic processes. Our results indicate that KYNA plays a protective role by down-regulating Bax expression and maintaining mitochondrial function in MPP(+)-induced neuronal cell death, and suggest that KYNA may have therapeutic potential in PD.
SN - 1618-1298
UR - https://www.unboundmedicine.com/medline/citation/18462830/Kynurenic_acid_attenuates_MPP_+__induced_dopaminergic_neuronal_cell_death_via_a_Bax_mediated_mitochondrial_pathway_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0171-9335(08)00061-7
DB - PRIME
DP - Unbound Medicine
ER -