Tags

Type your tag names separated by a space and hit enter

Cost-effectiveness of live attenuated influenza vaccine versus inactivated influenza vaccine among children aged 24-59 months in the United States.
Vaccine. 2008 Jun 02; 26(23):2841-8.V

Abstract

BACKGROUND

The US Advisory Committee on Immunization Practices (ACIP) recently expanded the influenza vaccine recommendation to include children 24-59 months of age. In a large head-to-head randomized controlled trial, live attenuated influenza vaccine, trivalent (LAIV) demonstrated a 54% relative reduction in culture-confirmed influenza illness compared with trivalent inactivated influenza vaccine (TIV) among children aged 24-59 months.

OBJECTIVE

To evaluate the relative cost and benefit between two influenza vaccines (LAIV and TIV) for healthy children 24-59 months of age.

METHODS

Using patient-level data from the clinical trial supplemented with cost data from published literature, we modeled the cost-effectiveness of these two vaccines. Effectiveness was measured in quality-adjusted life years (QALY) and cases of influenza avoided. The analysis used the societal perspective.

RESULTS

Due to its higher acquisition cost, LAIV increased vaccination costs by USD7.72 per child compared with TIV. However, compared with TIV, LAIV reduced the number of influenza illness cases and lowered the subsequent healthcare use of children and productivity losses of parents. The estimated offsets in direct and indirect costs saved USD15.80 and USD37.72 per vaccinated child, respectively. LAIV had a net total cost savings of USD45.80 per child relative to TIV. One-way and probabilistic sensitivity analyses indicated that the model was robust across a wide range of relative vaccine efficacy and cost estimates.

CONCLUSIONS

Due to its increased relative vaccine efficacy over TIV, LAIV reduced the burden of influenza and lowered both direct health care and societal costs among children 24-59 months of age.

Authors+Show Affiliations

United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA. bryan.luce@unitedbiosource.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18462851

Citation

Luce, Bryan R., et al. "Cost-effectiveness of Live Attenuated Influenza Vaccine Versus Inactivated Influenza Vaccine Among Children Aged 24-59 Months in the United States." Vaccine, vol. 26, no. 23, 2008, pp. 2841-8.
Luce BR, Nichol KL, Belshe RB, et al. Cost-effectiveness of live attenuated influenza vaccine versus inactivated influenza vaccine among children aged 24-59 months in the United States. Vaccine. 2008;26(23):2841-8.
Luce, B. R., Nichol, K. L., Belshe, R. B., Frick, K. D., Li, S. X., Boscoe, A., Rousculp, M. D., & Mahadevia, P. J. (2008). Cost-effectiveness of live attenuated influenza vaccine versus inactivated influenza vaccine among children aged 24-59 months in the United States. Vaccine, 26(23), 2841-8. https://doi.org/10.1016/j.vaccine.2008.03.046
Luce BR, et al. Cost-effectiveness of Live Attenuated Influenza Vaccine Versus Inactivated Influenza Vaccine Among Children Aged 24-59 Months in the United States. Vaccine. 2008 Jun 2;26(23):2841-8. PubMed PMID: 18462851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cost-effectiveness of live attenuated influenza vaccine versus inactivated influenza vaccine among children aged 24-59 months in the United States. AU - Luce,Bryan R, AU - Nichol,Kristin L, AU - Belshe,Robert B, AU - Frick,Kevin D, AU - Li,Su Xia, AU - Boscoe,Audra, AU - Rousculp,Matthew D, AU - Mahadevia,Parthiv J, Y1 - 2008/05/06/ PY - 2008/01/24/received PY - 2008/03/14/revised PY - 2008/03/20/accepted PY - 2008/5/9/pubmed PY - 2008/8/9/medline PY - 2008/5/9/entrez SP - 2841 EP - 8 JF - Vaccine JO - Vaccine VL - 26 IS - 23 N2 - BACKGROUND: The US Advisory Committee on Immunization Practices (ACIP) recently expanded the influenza vaccine recommendation to include children 24-59 months of age. In a large head-to-head randomized controlled trial, live attenuated influenza vaccine, trivalent (LAIV) demonstrated a 54% relative reduction in culture-confirmed influenza illness compared with trivalent inactivated influenza vaccine (TIV) among children aged 24-59 months. OBJECTIVE: To evaluate the relative cost and benefit between two influenza vaccines (LAIV and TIV) for healthy children 24-59 months of age. METHODS: Using patient-level data from the clinical trial supplemented with cost data from published literature, we modeled the cost-effectiveness of these two vaccines. Effectiveness was measured in quality-adjusted life years (QALY) and cases of influenza avoided. The analysis used the societal perspective. RESULTS: Due to its higher acquisition cost, LAIV increased vaccination costs by USD7.72 per child compared with TIV. However, compared with TIV, LAIV reduced the number of influenza illness cases and lowered the subsequent healthcare use of children and productivity losses of parents. The estimated offsets in direct and indirect costs saved USD15.80 and USD37.72 per vaccinated child, respectively. LAIV had a net total cost savings of USD45.80 per child relative to TIV. One-way and probabilistic sensitivity analyses indicated that the model was robust across a wide range of relative vaccine efficacy and cost estimates. CONCLUSIONS: Due to its increased relative vaccine efficacy over TIV, LAIV reduced the burden of influenza and lowered both direct health care and societal costs among children 24-59 months of age. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/18462851/Cost_effectiveness_of_live_attenuated_influenza_vaccine_versus_inactivated_influenza_vaccine_among_children_aged_24_59_months_in_the_United_States_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(08)00380-0 DB - PRIME DP - Unbound Medicine ER -