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Dyspepsia and IBS symptoms in patients with NERD, ERD and Barrett's esophagus.
Dig Dis 2008; 26(3):243-7DD

Abstract

INTRODUCTION

Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are highly prevalent in the general population as does gastroesophageal reflux disease (GERD). Therefore, it is expected that these conditions may frequently overlap.

OBJECTIVE

We aimed at evaluating the presence ofFD and IBS symptoms in patients with erosive (ERD), non-erosive reflux disease (NERD) and Barrett's esophagus (BE).

PATIENTS AND METHODS

71 patients presenting at the reflux disease outpatient clinic were prospectively included in this study. 33 patients had NERD, 25 ERD and 13 BE according to the Montreal classification. All patients with ERD and NERD had typical reflux symptoms, as assessed by a validated GERD questionnaire (RDQ). The diagnosis of functional dyspepsia and IBS symptoms was assessed according to the Rome III criteria.

RESULTS

IBS symptoms (bloating, abdominal pain, constipation and diarrhea) were slightly more prevalent in NERD (54.6, 63.6, 21.20, 24.2%, respectively) than in ERD (48.0, 44.0, 12.0, 20.0%, respectively) and in BE (53.9, 23.10, 15,4, 23.1%, respectively), but none of these differences reached statistical significance. NERD patients had more FD symptoms than patients with ERD or BE, but again this difference did not reach statistical significance.

CONCLUSION

Our data show that IBS and FD are common in the entire spectrum of GERD. The presence of these disorders might explain why many patients with GERD are deemed as treatment failures if they have no complete symptom relief with proton pump inhibitors.

Authors+Show Affiliations

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18463443

Citation

Neumann, Helmut, et al. "Dyspepsia and IBS Symptoms in Patients With NERD, ERD and Barrett's Esophagus." Digestive Diseases (Basel, Switzerland), vol. 26, no. 3, 2008, pp. 243-7.
Neumann H, Monkemuller K, Kandulski A, et al. Dyspepsia and IBS symptoms in patients with NERD, ERD and Barrett's esophagus. Dig Dis. 2008;26(3):243-7.
Neumann, H., Monkemuller, K., Kandulski, A., & Malfertheiner, P. (2008). Dyspepsia and IBS symptoms in patients with NERD, ERD and Barrett's esophagus. Digestive Diseases (Basel, Switzerland), 26(3), pp. 243-7. doi:10.1159/000121354.
Neumann H, et al. Dyspepsia and IBS Symptoms in Patients With NERD, ERD and Barrett's Esophagus. Dig Dis. 2008;26(3):243-7. PubMed PMID: 18463443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dyspepsia and IBS symptoms in patients with NERD, ERD and Barrett's esophagus. AU - Neumann,Helmut, AU - Monkemuller,Klaus, AU - Kandulski,Arne, AU - Malfertheiner,Peter, Y1 - 2008/05/07/ PY - 2008/5/9/pubmed PY - 2008/7/17/medline PY - 2008/5/9/entrez SP - 243 EP - 7 JF - Digestive diseases (Basel, Switzerland) JO - Dig Dis VL - 26 IS - 3 N2 - INTRODUCTION: Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are highly prevalent in the general population as does gastroesophageal reflux disease (GERD). Therefore, it is expected that these conditions may frequently overlap. OBJECTIVE: We aimed at evaluating the presence ofFD and IBS symptoms in patients with erosive (ERD), non-erosive reflux disease (NERD) and Barrett's esophagus (BE). PATIENTS AND METHODS: 71 patients presenting at the reflux disease outpatient clinic were prospectively included in this study. 33 patients had NERD, 25 ERD and 13 BE according to the Montreal classification. All patients with ERD and NERD had typical reflux symptoms, as assessed by a validated GERD questionnaire (RDQ). The diagnosis of functional dyspepsia and IBS symptoms was assessed according to the Rome III criteria. RESULTS: IBS symptoms (bloating, abdominal pain, constipation and diarrhea) were slightly more prevalent in NERD (54.6, 63.6, 21.20, 24.2%, respectively) than in ERD (48.0, 44.0, 12.0, 20.0%, respectively) and in BE (53.9, 23.10, 15,4, 23.1%, respectively), but none of these differences reached statistical significance. NERD patients had more FD symptoms than patients with ERD or BE, but again this difference did not reach statistical significance. CONCLUSION: Our data show that IBS and FD are common in the entire spectrum of GERD. The presence of these disorders might explain why many patients with GERD are deemed as treatment failures if they have no complete symptom relief with proton pump inhibitors. SN - 1421-9875 UR - https://www.unboundmedicine.com/medline/citation/18463443/Dyspepsia_and_IBS_symptoms_in_patients_with_NERD_ERD_and_Barrett's_esophagus_ L2 - https://www.karger.com?DOI=10.1159/000121354 DB - PRIME DP - Unbound Medicine ER -