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CSF/serum folate gradient: physiology and determinants with special reference to dementia.
Dement Geriatr Cogn Disord. 2008; 25(6):516-23.DG

Abstract

BACKGROUND

Folate depletion has been implicated as a risk factor for neurodegenerative disorders. We hypothesized that transport of folate to the cerebrospinal fluid (CSF) compartment could be involved in the pathophysiology of these disorders.

METHODS

The CSF/serum folate gradient (R(CSF/S)) was studied in 205 subjects with suspected cognitive disorder. Its relation to clinical and biochemical indices, including the integrity of the blood-CSF barrier, were characterized.

RESULTS

In subjects who were diagnosed as nondemented (ND) the mean R(CSF/S)+/- SD was 2.46 +/- 0.62 versus 2.09 +/- 0.67 (p = 0.008) in the dementia subgroup with a vascular component (VaD + mixed). The ND subgroup had higher CSF folate (p = 0.001) and lower serum homocysteine values (p = 0.001) than the VaD + mixed subgroup. The folate gradient R(CSF/S) was negatively correlated with serum folate (p < 0.001, R(2) = 0.518) and to the albumin ratio, a blood-CSF barrier biomarker (beta = -0.235). The Alzheimer patients had R(CSF/S) and albumin ratios similar to the ND subjects.

CONCLUSION

The R(CSF/S) was significantly lower in the VaD + mixed dementia subgroup, suggestive of a defect in the transport of folate over the choroid plexus that seems to be characteristic of, and limited to, the VaD + mixed dementia subgroup.

Authors+Show Affiliations

Department of Geriatrics, Orebro University Hospital, Orebro, Sweden. nils-olof.hagnelius@orebroll.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18463447

Citation

Hagnelius, Nils-Olof, et al. "CSF/serum Folate Gradient: Physiology and Determinants With Special Reference to Dementia." Dementia and Geriatric Cognitive Disorders, vol. 25, no. 6, 2008, pp. 516-23.
Hagnelius NO, Wahlund LO, Nilsson TK. CSF/serum folate gradient: physiology and determinants with special reference to dementia. Dement Geriatr Cogn Disord. 2008;25(6):516-23.
Hagnelius, N. O., Wahlund, L. O., & Nilsson, T. K. (2008). CSF/serum folate gradient: physiology and determinants with special reference to dementia. Dementia and Geriatric Cognitive Disorders, 25(6), 516-23. https://doi.org/10.1159/000129696
Hagnelius NO, Wahlund LO, Nilsson TK. CSF/serum Folate Gradient: Physiology and Determinants With Special Reference to Dementia. Dement Geriatr Cogn Disord. 2008;25(6):516-23. PubMed PMID: 18463447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CSF/serum folate gradient: physiology and determinants with special reference to dementia. AU - Hagnelius,Nils-Olof, AU - Wahlund,Lars-Olof, AU - Nilsson,Torbjörn K, Y1 - 2008/05/07/ PY - 2008/02/25/accepted PY - 2008/5/9/pubmed PY - 2008/10/8/medline PY - 2008/5/9/entrez SP - 516 EP - 23 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 25 IS - 6 N2 - BACKGROUND: Folate depletion has been implicated as a risk factor for neurodegenerative disorders. We hypothesized that transport of folate to the cerebrospinal fluid (CSF) compartment could be involved in the pathophysiology of these disorders. METHODS: The CSF/serum folate gradient (R(CSF/S)) was studied in 205 subjects with suspected cognitive disorder. Its relation to clinical and biochemical indices, including the integrity of the blood-CSF barrier, were characterized. RESULTS: In subjects who were diagnosed as nondemented (ND) the mean R(CSF/S)+/- SD was 2.46 +/- 0.62 versus 2.09 +/- 0.67 (p = 0.008) in the dementia subgroup with a vascular component (VaD + mixed). The ND subgroup had higher CSF folate (p = 0.001) and lower serum homocysteine values (p = 0.001) than the VaD + mixed subgroup. The folate gradient R(CSF/S) was negatively correlated with serum folate (p < 0.001, R(2) = 0.518) and to the albumin ratio, a blood-CSF barrier biomarker (beta = -0.235). The Alzheimer patients had R(CSF/S) and albumin ratios similar to the ND subjects. CONCLUSION: The R(CSF/S) was significantly lower in the VaD + mixed dementia subgroup, suggestive of a defect in the transport of folate over the choroid plexus that seems to be characteristic of, and limited to, the VaD + mixed dementia subgroup. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/18463447/CSF/serum_folate_gradient:_physiology_and_determinants_with_special_reference_to_dementia_ L2 - https://www.karger.com?DOI=10.1159/000129696 DB - PRIME DP - Unbound Medicine ER -