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Vitamin C intake and serum uric acid concentration in men.
J Rheumatol 2008; 35(9):1853-8JR

Abstract

OBJECTIVE

We examined associations between vitamin C intake and serum uric acid in men in a population-based study.

METHODS

We included 1387 men without hypertension and with body mass index (BMI) < 30 kg/m(2) in the Health Professional Follow-up Study. Dietary intake was assessed with a semiquantitative food frequency questionnaire validated for use in this population. Serum uric acid concentrations were measured.

RESULTS

Greater intakes of total vitamin C were significantly associated with lower serum uric acid concentrations, after adjustment for smoking, BMI, ethnicity, blood pressure, presence of gout, use of aspirin, and intake of energy, alcohol, dairy protein, fructose, meat, seafood and coffee. An inverse dose-response association was observed through vitamin C intake of 400-500 mg/day, and then reached a plateau. Adjusted mean uric acid concentrations across total vitamin C intake categories (< 90, 90-249, 250-499, 500-999, or > or = 1000 mg/day) were 6.4, 6.1, 6.0, 5.7, and 5.7 mg/dl, respectively (p for trend < 0.001). Greater vitamin C intake was associated with lower prevalence of hyperuricemia (serum uric acid > 6 mg/dl). Multivariate odds ratios for hyperuricemia across total vitamin C intake categories were 1 (reference), 0.58, 0.57, 0.38, and 0.34 (95% CI 0.20-0.58; P for trend < 0.001). When we used dietary data, which were assessed 4-8 years before blood collection, as predictors, we observed similar inverse associations between vitamin C intake and uric acid.

CONCLUSION

These population-based data indicate that vitamin C intake in men is inversely associated with serum uric acid concentrations. These findings support a potential role of vitamin C in the prevention of hyperuricemia and gout.

Authors+Show Affiliations

Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA. xgao@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18464304

Citation

Gao, Xiang, et al. "Vitamin C Intake and Serum Uric Acid Concentration in Men." The Journal of Rheumatology, vol. 35, no. 9, 2008, pp. 1853-8.
Gao X, Curhan G, Forman JP, et al. Vitamin C intake and serum uric acid concentration in men. J Rheumatol. 2008;35(9):1853-8.
Gao, X., Curhan, G., Forman, J. P., Ascherio, A., & Choi, H. K. (2008). Vitamin C intake and serum uric acid concentration in men. The Journal of Rheumatology, 35(9), pp. 1853-8.
Gao X, et al. Vitamin C Intake and Serum Uric Acid Concentration in Men. J Rheumatol. 2008;35(9):1853-8. PubMed PMID: 18464304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin C intake and serum uric acid concentration in men. AU - Gao,Xiang, AU - Curhan,Gary, AU - Forman,John P, AU - Ascherio,Alberto, AU - Choi,Hyon K, Y1 - 2008/05/01/ PY - 2008/5/9/pubmed PY - 2008/12/17/medline PY - 2008/5/9/entrez SP - 1853 EP - 8 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 35 IS - 9 N2 - OBJECTIVE: We examined associations between vitamin C intake and serum uric acid in men in a population-based study. METHODS: We included 1387 men without hypertension and with body mass index (BMI) < 30 kg/m(2) in the Health Professional Follow-up Study. Dietary intake was assessed with a semiquantitative food frequency questionnaire validated for use in this population. Serum uric acid concentrations were measured. RESULTS: Greater intakes of total vitamin C were significantly associated with lower serum uric acid concentrations, after adjustment for smoking, BMI, ethnicity, blood pressure, presence of gout, use of aspirin, and intake of energy, alcohol, dairy protein, fructose, meat, seafood and coffee. An inverse dose-response association was observed through vitamin C intake of 400-500 mg/day, and then reached a plateau. Adjusted mean uric acid concentrations across total vitamin C intake categories (< 90, 90-249, 250-499, 500-999, or > or = 1000 mg/day) were 6.4, 6.1, 6.0, 5.7, and 5.7 mg/dl, respectively (p for trend < 0.001). Greater vitamin C intake was associated with lower prevalence of hyperuricemia (serum uric acid > 6 mg/dl). Multivariate odds ratios for hyperuricemia across total vitamin C intake categories were 1 (reference), 0.58, 0.57, 0.38, and 0.34 (95% CI 0.20-0.58; P for trend < 0.001). When we used dietary data, which were assessed 4-8 years before blood collection, as predictors, we observed similar inverse associations between vitamin C intake and uric acid. CONCLUSION: These population-based data indicate that vitamin C intake in men is inversely associated with serum uric acid concentrations. These findings support a potential role of vitamin C in the prevention of hyperuricemia and gout. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/18464304/Vitamin_C_intake_and_serum_uric_acid_concentration_in_men_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=18464304 DB - PRIME DP - Unbound Medicine ER -