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Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction.
Thyroid 2008; 18(5):545-50T

Abstract

BACKGROUND

There are potentially complex interrelationships between thyroid function, leptin, ghrelin, body mass index (BMI), and percentage of body fat (%BF). The goal of this study was to determine if normalization of thyroid status in premenopausal women with hyperthyroidism and hypothyroidism would be associated with changes in serum leptin and ghrelin in the absence of thyroid dysfunction treatment-associated changes in BMI and %BF.

METHODS

The study was carried out in 47 selected premenopausal women: 17 with hyperthyroidism, 11 with hypothyroidism, and 19 healthy individuals who constituted the control group. Patients with thyroid dysfunction were selected for study if their BMI and %BF did not change after treatment of thyroid dysfunction. Subjects in the control group were selected on the basis of the age, BMI, and the %BF characteristics of the patients with thyroid dysfunction. Concentrations of free thyroxine (fT4), free triiodothyronine (fT3), thyrotropin, leptin, and ghrelin in serum were determined before and after treatment of thyroid dysfunction and in the control group.

RESULTS

Serum leptin concentrations were similar in patients with hyperthyroidism and hypothyroidism before treatment and in normal subjects and did not change significantly after treatment of hyperthyroidism or hypothyroidism. Serum ghrelin concentrations were lower in patients with hyperthyroidism, and higher in patients with hypothyroidism than in the control group (hypothyroidism = 2345 (1157-7015) [median (range)], hyperthyroidism = 1205 (438-2914), control = 2398 (1542-4920), p < 0.05).

CONCLUSIONS

In premenopausal women with hyperthyroidism or hypothyroidism, treatment of thyroid dysfunction that is not associated with changes in BMI or %BF does not influence serum leptin but does affect serum ghrelin. Thyroid status itself, in the absence of alterations in the BMI and %BF, has an important influence on circulating ghrelin but not leptin.

Authors+Show Affiliations

Department of Radiation Oncology, Hospital of St. Leszczynski, ul. Raciborska 26, Katowice, Poland. braclik@o2.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

18466078

Citation

Braclik, Mariusz, et al. "Serum Leptin and Ghrelin Levels in Premenopausal Women With Stable Body Mass Index During Treatment of Thyroid Dysfunction." Thyroid : Official Journal of the American Thyroid Association, vol. 18, no. 5, 2008, pp. 545-50.
Braclik M, Marcisz C, Giebel S, et al. Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction. Thyroid. 2008;18(5):545-50.
Braclik, M., Marcisz, C., Giebel, S., & Orzeł, A. (2008). Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction. Thyroid : Official Journal of the American Thyroid Association, 18(5), pp. 545-50. doi:10.1089/thy.2007.0300.
Braclik M, et al. Serum Leptin and Ghrelin Levels in Premenopausal Women With Stable Body Mass Index During Treatment of Thyroid Dysfunction. Thyroid. 2008;18(5):545-50. PubMed PMID: 18466078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction. AU - Braclik,Mariusz, AU - Marcisz,Czesław, AU - Giebel,Sebastian, AU - Orzeł,Arkadiusz, PY - 2008/5/10/pubmed PY - 2008/7/30/medline PY - 2008/5/10/entrez SP - 545 EP - 50 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 18 IS - 5 N2 - BACKGROUND: There are potentially complex interrelationships between thyroid function, leptin, ghrelin, body mass index (BMI), and percentage of body fat (%BF). The goal of this study was to determine if normalization of thyroid status in premenopausal women with hyperthyroidism and hypothyroidism would be associated with changes in serum leptin and ghrelin in the absence of thyroid dysfunction treatment-associated changes in BMI and %BF. METHODS: The study was carried out in 47 selected premenopausal women: 17 with hyperthyroidism, 11 with hypothyroidism, and 19 healthy individuals who constituted the control group. Patients with thyroid dysfunction were selected for study if their BMI and %BF did not change after treatment of thyroid dysfunction. Subjects in the control group were selected on the basis of the age, BMI, and the %BF characteristics of the patients with thyroid dysfunction. Concentrations of free thyroxine (fT4), free triiodothyronine (fT3), thyrotropin, leptin, and ghrelin in serum were determined before and after treatment of thyroid dysfunction and in the control group. RESULTS: Serum leptin concentrations were similar in patients with hyperthyroidism and hypothyroidism before treatment and in normal subjects and did not change significantly after treatment of hyperthyroidism or hypothyroidism. Serum ghrelin concentrations were lower in patients with hyperthyroidism, and higher in patients with hypothyroidism than in the control group (hypothyroidism = 2345 (1157-7015) [median (range)], hyperthyroidism = 1205 (438-2914), control = 2398 (1542-4920), p < 0.05). CONCLUSIONS: In premenopausal women with hyperthyroidism or hypothyroidism, treatment of thyroid dysfunction that is not associated with changes in BMI or %BF does not influence serum leptin but does affect serum ghrelin. Thyroid status itself, in the absence of alterations in the BMI and %BF, has an important influence on circulating ghrelin but not leptin. SN - 1050-7256 UR - https://www.unboundmedicine.com/medline/citation/18466078/Serum_leptin_and_ghrelin_levels_in_premenopausal_women_with_stable_body_mass_index_during_treatment_of_thyroid_dysfunction_ L2 - https://www.liebertpub.com/doi/full/10.1089/thy.2007.0300?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -