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Prevalence of autoimmune thyroid disease and thyroid dysfunction in young Brazilian patients with type 1 diabetes.

Abstract

Patients with an autoimmune condition are known to be at higher risk of developing other autoimmune disorders. Type 1 diabetes may be associated with additional autoimmune disorders including autoimmune thyroid disease. The aim of this study was to investigate the prevalence of thyroid autoantibodies in a group of children, adolescents, and young adults with type 1 diabetes from northeastern Brazil as well as their significance for the development of thyroid disorders. The study design was cross-sectional and descriptive, analyzing young people with a previous type 1 diabetes diagnosis. Two hundred and fourteen children and adolescents with prior diagnosis of type 1 diabetes were evaluated. Antibodies to thyroperoxidase (anti-TPO) were determined in all patients and thyroid-stimulating hormone (TSH) levels. The anti-TPO antibody test was positive in 54 out of the 214 patients studied, resulting in an overall prevalence of 25.2%. Among the anti-TPO-positive subjects, females were predominant (72%) over males (28%) (p < 0.001). A total of 55.5% patients with positive anti-TPO antibodies had abnormal TSH levels. Clinically significant hypothyroidism was found in 29.6% and subclinical hypothyroidism in 22.2% of patients with positive anti-TPO. Hyperthyroidism was present in only 3% of them. Our results demonstrate the high prevalence of autoimmune thyroiditis in patients with type 1 diabetes and the need for these patients of regular screening to make a precocious diagnosis of thyroid dysfunction.

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  • Authors+Show Affiliations

    ,

    Pediatric Endocrinology Unit of Clinical Hospital, Federal University of Pernambuco, Recife, Pernambuco, Brazil. jacqueline.araujo@gmail.com

    , , , , , , , ,

    Source

    Pediatric diabetes 9:4 Pt 1 2008 Jul 28 pg 272-6

    MeSH

    Adolescent
    Autoantibodies
    Autoimmune Diseases
    Brazil
    Child
    Comorbidity
    Diabetes Mellitus, Type 1
    Female
    Humans
    Hyperthyroidism
    Hypothyroidism
    Iodide Peroxidase
    Male
    Prevalence
    Thyrotropin
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18466214

    Citation

    Araujo, Jacqueline, et al. "Prevalence of Autoimmune Thyroid Disease and Thyroid Dysfunction in Young Brazilian Patients With Type 1 Diabetes." Pediatric Diabetes, vol. 9, no. 4 Pt 1, 2008, pp. 272-6.
    Araujo J, Brandão LA, Guimarães RL, et al. Prevalence of autoimmune thyroid disease and thyroid dysfunction in young Brazilian patients with type 1 diabetes. Pediatr Diabetes. 2008;9(4 Pt 1):272-6.
    Araujo, J., Brandão, L. A., Guimarães, R. L., Santos, S., Falcão, E. A., Milanese, M., ... Crovella, S. (2008). Prevalence of autoimmune thyroid disease and thyroid dysfunction in young Brazilian patients with type 1 diabetes. Pediatric Diabetes, 9(4 Pt 1), pp. 272-6. doi:10.1111/j.1399-5448.2008.00394.x.
    Araujo J, et al. Prevalence of Autoimmune Thyroid Disease and Thyroid Dysfunction in Young Brazilian Patients With Type 1 Diabetes. Pediatr Diabetes. 2008 Jul 28;9(4 Pt 1):272-6. PubMed PMID: 18466214.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence of autoimmune thyroid disease and thyroid dysfunction in young Brazilian patients with type 1 diabetes. AU - Araujo,Jacqueline, AU - Brandão,Lucas A C, AU - Guimarães,Rafael L, AU - Santos,Sérgio, AU - Falcão,Elcy A, AU - Milanese,Michele, AU - Segat,Ludovica, AU - Souza,Paulo R, AU - de Lima-Filho,José Luiz, AU - Crovella,Sergio, Y1 - 2008/05/07/ PY - 2008/5/10/pubmed PY - 2009/2/4/medline PY - 2008/5/10/entrez SP - 272 EP - 6 JF - Pediatric diabetes JO - Pediatr Diabetes VL - 9 IS - 4 Pt 1 N2 - Patients with an autoimmune condition are known to be at higher risk of developing other autoimmune disorders. Type 1 diabetes may be associated with additional autoimmune disorders including autoimmune thyroid disease. The aim of this study was to investigate the prevalence of thyroid autoantibodies in a group of children, adolescents, and young adults with type 1 diabetes from northeastern Brazil as well as their significance for the development of thyroid disorders. The study design was cross-sectional and descriptive, analyzing young people with a previous type 1 diabetes diagnosis. Two hundred and fourteen children and adolescents with prior diagnosis of type 1 diabetes were evaluated. Antibodies to thyroperoxidase (anti-TPO) were determined in all patients and thyroid-stimulating hormone (TSH) levels. The anti-TPO antibody test was positive in 54 out of the 214 patients studied, resulting in an overall prevalence of 25.2%. Among the anti-TPO-positive subjects, females were predominant (72%) over males (28%) (p < 0.001). A total of 55.5% patients with positive anti-TPO antibodies had abnormal TSH levels. Clinically significant hypothyroidism was found in 29.6% and subclinical hypothyroidism in 22.2% of patients with positive anti-TPO. Hyperthyroidism was present in only 3% of them. Our results demonstrate the high prevalence of autoimmune thyroiditis in patients with type 1 diabetes and the need for these patients of regular screening to make a precocious diagnosis of thyroid dysfunction. SN - 1399-5448 UR - https://www.unboundmedicine.com/medline/citation/18466214/Prevalence_of_autoimmune_thyroid_disease_and_thyroid_dysfunction_in_young_Brazilian_patients_with_type_1_diabetes_ L2 - https://doi.org/10.1111/j.1399-5448.2008.00394.x DB - PRIME DP - Unbound Medicine ER -