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Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala.
J Neurochem. 2008 Jul; 106(2):889-99.JN

Abstract

Stimulated exocytosis and endocytosis of post-synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid subtype of glutamate receptors (AMPARs) have been proposed as primary mechanisms for the expression of hippocampal CA1 long-term potentiation (LTP) and long-term depression (LTD), respectively. LTP and LTD, the two most well characterized forms of synaptic plasticity, are thought to be important for learning and memory in behaving animals. Both LTP and LTD can also be induced in the lateral amygdala (LA), a critical structure involved in fear conditioning. However, the role of AMPAR trafficking in the expression of either LTP or LTD in this structure remains unclear. In this study, we show that NMDA receptor-dependent LTP and LTD can be reliably induced at the synapses of the auditory thalamic inputs to the LA in brain slices. The expression of LTP was prevented by post-synaptic blockade of vesicle-mediated exocytosis with application of a light chain of Clostridium tetanus neurotoxin and was associated with increased cell-surface AMPAR expression. In contrast, the expression of LTD was prevented by post-synaptic application of a glutamate receptor 2-derived interference peptide, which specifically blocks the stimulated clathrin-dependent endocytosis of AMPARs, and was correlated with a reduction in plasma membrane-surface expression of AMPARs. These results strongly suggest that regulated trafficking of post-synaptic AMPARs is also involved in the expression of LTP and LTD in the LA.

Authors+Show Affiliations

Department of Physiology, Shandong University School of Medicine, Jinan, Shandong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18466342

Citation

Yu, Shu Yan, et al. "Role of AMPA Receptor Trafficking in NMDA Receptor-dependent Synaptic Plasticity in the Rat Lateral Amygdala." Journal of Neurochemistry, vol. 106, no. 2, 2008, pp. 889-99.
Yu SY, Wu DC, Liu L, et al. Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala. J Neurochem. 2008;106(2):889-99.
Yu, S. Y., Wu, D. C., Liu, L., Ge, Y., & Wang, Y. T. (2008). Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala. Journal of Neurochemistry, 106(2), 889-99. https://doi.org/10.1111/j.1471-4159.2008.05461.x
Yu SY, et al. Role of AMPA Receptor Trafficking in NMDA Receptor-dependent Synaptic Plasticity in the Rat Lateral Amygdala. J Neurochem. 2008;106(2):889-99. PubMed PMID: 18466342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala. AU - Yu,Shu Yan, AU - Wu,Dong Chuan, AU - Liu,Lidong, AU - Ge,Yuan, AU - Wang,Yu Tian, Y1 - 2008/05/04/ PY - 2008/5/10/pubmed PY - 2008/9/17/medline PY - 2008/5/10/entrez SP - 889 EP - 99 JF - Journal of neurochemistry JO - J Neurochem VL - 106 IS - 2 N2 - Stimulated exocytosis and endocytosis of post-synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid subtype of glutamate receptors (AMPARs) have been proposed as primary mechanisms for the expression of hippocampal CA1 long-term potentiation (LTP) and long-term depression (LTD), respectively. LTP and LTD, the two most well characterized forms of synaptic plasticity, are thought to be important for learning and memory in behaving animals. Both LTP and LTD can also be induced in the lateral amygdala (LA), a critical structure involved in fear conditioning. However, the role of AMPAR trafficking in the expression of either LTP or LTD in this structure remains unclear. In this study, we show that NMDA receptor-dependent LTP and LTD can be reliably induced at the synapses of the auditory thalamic inputs to the LA in brain slices. The expression of LTP was prevented by post-synaptic blockade of vesicle-mediated exocytosis with application of a light chain of Clostridium tetanus neurotoxin and was associated with increased cell-surface AMPAR expression. In contrast, the expression of LTD was prevented by post-synaptic application of a glutamate receptor 2-derived interference peptide, which specifically blocks the stimulated clathrin-dependent endocytosis of AMPARs, and was correlated with a reduction in plasma membrane-surface expression of AMPARs. These results strongly suggest that regulated trafficking of post-synaptic AMPARs is also involved in the expression of LTP and LTD in the LA. SN - 1471-4159 UR - https://www.unboundmedicine.com/medline/citation/18466342/Role_of_AMPA_receptor_trafficking_in_NMDA_receptor_dependent_synaptic_plasticity_in_the_rat_lateral_amygdala_ L2 - https://doi.org/10.1111/j.1471-4159.2008.05461.x DB - PRIME DP - Unbound Medicine ER -