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Racial analysis of patients with myocardial infarction complicated by heart failure and/or left ventricular dysfunction treated with valsartan, captopril, or both.
J Am Coll Cardiol. 2008 May 13; 51(19):1865-71.JACC

Abstract

OBJECTIVES

African Americans have a high incidence of heart failure (HF). Limited retrospective observational subgroup analyses of patients with left ventricular systolic dysfunction (LVSD) suggest marginal benefit of angiotensin-converting enzyme inhibitors in the prevention of HF hospitalizations or total mortality in African Americans.

BACKGROUND

Very few data exist concerning the effectiveness of angiotensin receptor blockers in this population.

METHODS

Baseline characteristics, treatments, and outcomes of patients from the U.S. (3,390 white and 340 African-American patients) in the VALIANT (VALsartan In Acute myocardial iNfarcTion) trial were compared. This trial included patients with an acute myocardial infarction (MI) after initial stabilization and documented LVSD and/or HF. Patients were randomly assigned to receive treatment with valsartan, captopril, or the combination; follow-up continued for up to 3 years (median 24.7 months).

RESULTS

African Americans had more coronary risk factors, more markers of poor outcome after MI, and were less likely to be revascularized when compared with white patients. After adjusting for treatment assignment, baseline characteristics, and post-infarction parameters, no difference was found in the 3-year rate of all-cause mortality, cardiovascular mortality, rehospitalization for HF, recurrent MI, or stroke between the 2 groups.

CONCLUSIONS

African Americans sustaining an acute MI with LVSD and/or HF had similar clinical outcomes compared with white Americans. Valsartan, captopril, or the combination had comparable effects on cardiovascular morbidity and mortality in African Americans and white Americans.

Authors+Show Affiliations

Hypertension and Clinical Pharmacology, Medical College of Georgia, Augusta, Georgia 30912, USA. mprisant@mail.mcg.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18466801

Citation

Prisant, L Michael, et al. "Racial Analysis of Patients With Myocardial Infarction Complicated By Heart Failure And/or Left Ventricular Dysfunction Treated With Valsartan, Captopril, or Both." Journal of the American College of Cardiology, vol. 51, no. 19, 2008, pp. 1865-71.
Prisant LM, Thomas KL, Lewis EF, et al. Racial analysis of patients with myocardial infarction complicated by heart failure and/or left ventricular dysfunction treated with valsartan, captopril, or both. J Am Coll Cardiol. 2008;51(19):1865-71.
Prisant, L. M., Thomas, K. L., Lewis, E. F., Huang, Z., Francis, G. S., Weaver, W. D., Pfeffer, M. A., McMurray, J. J., Califf, R. M., & Velazquez, E. J. (2008). Racial analysis of patients with myocardial infarction complicated by heart failure and/or left ventricular dysfunction treated with valsartan, captopril, or both. Journal of the American College of Cardiology, 51(19), 1865-71. https://doi.org/10.1016/j.jacc.2007.12.050
Prisant LM, et al. Racial Analysis of Patients With Myocardial Infarction Complicated By Heart Failure And/or Left Ventricular Dysfunction Treated With Valsartan, Captopril, or Both. J Am Coll Cardiol. 2008 May 13;51(19):1865-71. PubMed PMID: 18466801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial analysis of patients with myocardial infarction complicated by heart failure and/or left ventricular dysfunction treated with valsartan, captopril, or both. AU - Prisant,L Michael, AU - Thomas,Kevin L, AU - Lewis,Eldrin F, AU - Huang,Zhen, AU - Francis,Gary S, AU - Weaver,W Douglas, AU - Pfeffer,Marc A, AU - McMurray,John J V, AU - Califf,Robert M, AU - Velazquez,Eric J, PY - 2006/12/01/received PY - 2007/12/07/revised PY - 2007/12/11/accepted PY - 2008/5/10/pubmed PY - 2008/6/14/medline PY - 2008/5/10/entrez SP - 1865 EP - 71 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 51 IS - 19 N2 - OBJECTIVES: African Americans have a high incidence of heart failure (HF). Limited retrospective observational subgroup analyses of patients with left ventricular systolic dysfunction (LVSD) suggest marginal benefit of angiotensin-converting enzyme inhibitors in the prevention of HF hospitalizations or total mortality in African Americans. BACKGROUND: Very few data exist concerning the effectiveness of angiotensin receptor blockers in this population. METHODS: Baseline characteristics, treatments, and outcomes of patients from the U.S. (3,390 white and 340 African-American patients) in the VALIANT (VALsartan In Acute myocardial iNfarcTion) trial were compared. This trial included patients with an acute myocardial infarction (MI) after initial stabilization and documented LVSD and/or HF. Patients were randomly assigned to receive treatment with valsartan, captopril, or the combination; follow-up continued for up to 3 years (median 24.7 months). RESULTS: African Americans had more coronary risk factors, more markers of poor outcome after MI, and were less likely to be revascularized when compared with white patients. After adjusting for treatment assignment, baseline characteristics, and post-infarction parameters, no difference was found in the 3-year rate of all-cause mortality, cardiovascular mortality, rehospitalization for HF, recurrent MI, or stroke between the 2 groups. CONCLUSIONS: African Americans sustaining an acute MI with LVSD and/or HF had similar clinical outcomes compared with white Americans. Valsartan, captopril, or the combination had comparable effects on cardiovascular morbidity and mortality in African Americans and white Americans. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/18466801/Racial_analysis_of_patients_with_myocardial_infarction_complicated_by_heart_failure_and/or_left_ventricular_dysfunction_treated_with_valsartan_captopril_or_both_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(08)00707-9 DB - PRIME DP - Unbound Medicine ER -