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Hippocampal shape differences in dementia with Lewy bodies.
Neuroimage. 2008 Jul 01; 41(3):699-705.N

Abstract

To assess the morphological changes of the hippocampus in Lewy body dementia (LBD) patients we used radial atrophy mapping, a mathematical modeling method sensitive to subtle differences in hippocampal shape. T1-weighted high resolution magnetic resonance (MR) scans were acquired from 14 LBD and 28 controls of similar age and gender, and were compared to those of 28 patients with Alzheimer's disease (AD) described previously. MR images were normalized by linear (12 parameter) transformation to a customized template. The hippocampal formation was isolated by manual tracing. Group differences were assessed with algorithms that average hippocampal shapes across subjects, using three-dimensional parametric surface mesh models. In LBD patients, significant tissue loss amounting to 10-20% was found in the hippocampal subregions corresponding to the anterior portion of the CA1 field on both sides, along the longitudinal midline in the dorsal aspect within the CA2-3 field, and in the subiculum and presubiculum. The direct comparisons between LBD and AD patients showed that this pattern of local atrophy is different from that characteristic of AD. LBD pattern of hippocampal atrophy might be related to the peculiar neuropathology of the disease.

Authors+Show Affiliations

LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine - IRCCS Centro S. Giovanni di Dio - FBF, via Pilastroni 4, 25125 Brescia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18467130

Citation

Sabattoli, F, et al. "Hippocampal Shape Differences in Dementia With Lewy Bodies." NeuroImage, vol. 41, no. 3, 2008, pp. 699-705.
Sabattoli F, Boccardi M, Galluzzi S, et al. Hippocampal shape differences in dementia with Lewy bodies. Neuroimage. 2008;41(3):699-705.
Sabattoli, F., Boccardi, M., Galluzzi, S., Treves, A., Thompson, P. M., & Frisoni, G. B. (2008). Hippocampal shape differences in dementia with Lewy bodies. NeuroImage, 41(3), 699-705. https://doi.org/10.1016/j.neuroimage.2008.02.060
Sabattoli F, et al. Hippocampal Shape Differences in Dementia With Lewy Bodies. Neuroimage. 2008 Jul 1;41(3):699-705. PubMed PMID: 18467130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal shape differences in dementia with Lewy bodies. AU - Sabattoli,F, AU - Boccardi,M, AU - Galluzzi,S, AU - Treves,A, AU - Thompson,P M, AU - Frisoni,G B, Y1 - 2008/03/14/ PY - 2007/12/17/received PY - 2008/02/11/revised PY - 2008/02/27/accepted PY - 2008/5/10/pubmed PY - 2008/8/15/medline PY - 2008/5/10/entrez SP - 699 EP - 705 JF - NeuroImage JO - Neuroimage VL - 41 IS - 3 N2 - To assess the morphological changes of the hippocampus in Lewy body dementia (LBD) patients we used radial atrophy mapping, a mathematical modeling method sensitive to subtle differences in hippocampal shape. T1-weighted high resolution magnetic resonance (MR) scans were acquired from 14 LBD and 28 controls of similar age and gender, and were compared to those of 28 patients with Alzheimer's disease (AD) described previously. MR images were normalized by linear (12 parameter) transformation to a customized template. The hippocampal formation was isolated by manual tracing. Group differences were assessed with algorithms that average hippocampal shapes across subjects, using three-dimensional parametric surface mesh models. In LBD patients, significant tissue loss amounting to 10-20% was found in the hippocampal subregions corresponding to the anterior portion of the CA1 field on both sides, along the longitudinal midline in the dorsal aspect within the CA2-3 field, and in the subiculum and presubiculum. The direct comparisons between LBD and AD patients showed that this pattern of local atrophy is different from that characteristic of AD. LBD pattern of hippocampal atrophy might be related to the peculiar neuropathology of the disease. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/18467130/Hippocampal_shape_differences_in_dementia_with_Lewy_bodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(08)00197-3 DB - PRIME DP - Unbound Medicine ER -