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Characteristics of an ideal rotavirus vaccine.
Clin Pediatr (Phila) 2008; 47(6):555-63CPed

Abstract

Rotavirus gastroenteritis primarily affects children younger than 5 years of age and is the leading cause of diarrhea-related hospitalizations worldwide. The substantial morbidity associated with this disease and the major burden on healthcare resources underscore the need for an effective vaccine. Two recently developed vaccines (RotaTeq [rotavirus vaccine, live, oral, pentavalent], and Rotarix [rotavirus vaccine, live]) share some characteristics of an ideal rotavirus vaccine. High efficacy, excellent tolerability, and no increased risk of intussusception were shown in separate clinical trials of more than 60,000 infants for each trial, as well as in smaller phase 3 clinical trials of each vaccine. Vaccination against rotavirus will substantially reduce rotavirus gastroenteritis-associated morbidity and mortality and, in so doing, bring about a significant reduction in rotavirus gastroenteritis-associated healthcare utilization.

Authors+Show Affiliations

Primary Physicians Research, Pittsburgh, Pennsylvania 15241, USA. KSRPPR@aol.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18467670

Citation

Reisinger, Keith S., and Stan L. Block. "Characteristics of an Ideal Rotavirus Vaccine." Clinical Pediatrics, vol. 47, no. 6, 2008, pp. 555-63.
Reisinger KS, Block SL. Characteristics of an ideal rotavirus vaccine. Clin Pediatr (Phila). 2008;47(6):555-63.
Reisinger, K. S., & Block, S. L. (2008). Characteristics of an ideal rotavirus vaccine. Clinical Pediatrics, 47(6), pp. 555-63. doi:10.1177/0009922808314903.
Reisinger KS, Block SL. Characteristics of an Ideal Rotavirus Vaccine. Clin Pediatr (Phila). 2008;47(6):555-63. PubMed PMID: 18467670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of an ideal rotavirus vaccine. AU - Reisinger,Keith S, AU - Block,Stan L, Y1 - 2008/05/08/ PY - 2008/5/10/pubmed PY - 2008/10/29/medline PY - 2008/5/10/entrez SP - 555 EP - 63 JF - Clinical pediatrics JO - Clin Pediatr (Phila) VL - 47 IS - 6 N2 - Rotavirus gastroenteritis primarily affects children younger than 5 years of age and is the leading cause of diarrhea-related hospitalizations worldwide. The substantial morbidity associated with this disease and the major burden on healthcare resources underscore the need for an effective vaccine. Two recently developed vaccines (RotaTeq [rotavirus vaccine, live, oral, pentavalent], and Rotarix [rotavirus vaccine, live]) share some characteristics of an ideal rotavirus vaccine. High efficacy, excellent tolerability, and no increased risk of intussusception were shown in separate clinical trials of more than 60,000 infants for each trial, as well as in smaller phase 3 clinical trials of each vaccine. Vaccination against rotavirus will substantially reduce rotavirus gastroenteritis-associated morbidity and mortality and, in so doing, bring about a significant reduction in rotavirus gastroenteritis-associated healthcare utilization. SN - 0009-9228 UR - https://www.unboundmedicine.com/medline/citation/18467670/Characteristics_of_an_ideal_rotavirus_vaccine_ L2 - http://journals.sagepub.com/doi/full/10.1177/0009922808314903?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -