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Solid-state characterization and dissolution properties of bicalutamide-beta-cyclodextrin inclusion complex.
Pharmazie. 2008 Apr; 63(4):282-5.P

Abstract

The solid-state properties and dissolution profile of bicalutamide beta-cyclodextrin (betaCD) inclusion complex were investigated. The phase solubility profile of bicalutamide with beta-cyclodextrin was classified as A(L)-type. Stability constant with 1:1 molar ratio was calculated from the phase solubility diagram and the aqueous solubility of bicalutamide was found to be enhanced by 86% for beta-cyclodextrin. Binary systems of bicalutamide with betaCD were prepared by the kneading method. The solid-state properties of the complex were characterized by differential scanning calorimetry, Fourier transformation-infrared spectroscopy and X-ray powder diffractometry. It could be concluded that bicalutamide could form an inclusion complex with beta-cyclodextrin. The dissolution profile of the inclusion complex was determined and compared with those of bicalutamide alone and its physical mixture. The dissolution rate of bicalutamide was significantly increased bycomplexation with betaCD, as compared with pure drug and physical mixture.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18468387

Citation

Patil, A L., et al. "Solid-state Characterization and Dissolution Properties of Bicalutamide-beta-cyclodextrin Inclusion Complex." Die Pharmazie, vol. 63, no. 4, 2008, pp. 282-5.
Patil AL, Pore YV, Kuchekar BS, et al. Solid-state characterization and dissolution properties of bicalutamide-beta-cyclodextrin inclusion complex. Pharmazie. 2008;63(4):282-5.
Patil, A. L., Pore, Y. V., Kuchekar, B. S., & Late, S. G. (2008). Solid-state characterization and dissolution properties of bicalutamide-beta-cyclodextrin inclusion complex. Die Pharmazie, 63(4), 282-5.
Patil AL, et al. Solid-state Characterization and Dissolution Properties of Bicalutamide-beta-cyclodextrin Inclusion Complex. Pharmazie. 2008;63(4):282-5. PubMed PMID: 18468387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solid-state characterization and dissolution properties of bicalutamide-beta-cyclodextrin inclusion complex. AU - Patil,A L, AU - Pore,Y V, AU - Kuchekar,B S, AU - Late,S G, PY - 2008/5/13/pubmed PY - 2008/6/19/medline PY - 2008/5/13/entrez SP - 282 EP - 5 JF - Die Pharmazie JO - Pharmazie VL - 63 IS - 4 N2 - The solid-state properties and dissolution profile of bicalutamide beta-cyclodextrin (betaCD) inclusion complex were investigated. The phase solubility profile of bicalutamide with beta-cyclodextrin was classified as A(L)-type. Stability constant with 1:1 molar ratio was calculated from the phase solubility diagram and the aqueous solubility of bicalutamide was found to be enhanced by 86% for beta-cyclodextrin. Binary systems of bicalutamide with betaCD were prepared by the kneading method. The solid-state properties of the complex were characterized by differential scanning calorimetry, Fourier transformation-infrared spectroscopy and X-ray powder diffractometry. It could be concluded that bicalutamide could form an inclusion complex with beta-cyclodextrin. The dissolution profile of the inclusion complex was determined and compared with those of bicalutamide alone and its physical mixture. The dissolution rate of bicalutamide was significantly increased bycomplexation with betaCD, as compared with pure drug and physical mixture. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/18468387/Solid_state_characterization_and_dissolution_properties_of_bicalutamide_beta_cyclodextrin_inclusion_complex_ DB - PRIME DP - Unbound Medicine ER -