Tags

Type your tag names separated by a space and hit enter

Effect of antibiotic therapy on interleukin-6 in fresh semen and postmasturbation urine samples of patients with chronic prostatitis/chronic pelvic pain syndrome.
Urology. 2008 Aug; 72(2):336-9.U

Abstract

OBJECTIVES

To investigate the effect of antibiotic therapy on interleukin (IL)-6 in fresh semen and postmasturbation urine samples of patients with chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS).

METHODS

A total of 128 patients with CP/CPPS prospectively underwent the evaluation of IL-6 in fresh semen and postmasturbation urine samples. At 6 weeks after 4 weeks antibiotic therapy, the IL-6 levels were re-evaluated.

RESULTS

Of the 128 patients, 109 (85.2%) were available for our analysis. Of the 109 patients, 72 (66.1%) met the criteria for National Institutes of Health (NIH) classification for inflammatory CP/CPPS (type IIIa) and 37 (33.9%) met the NIH criteria for noninflammatory CP/CPPS (type IIIb). Before antibiotic therapy, 86 patients (78.9%), irrespective of NIH classification, had an increased IL-6 level in fresh semen; 64 (88.9%) patients with CP/CPPS type IIIa and 22 (59.5%) with type IIIb CP/CPPS had increased IL-6 levels. After 4 weeks of therapy, a significant reduction was found in the IL-6 level, with only 44 (40.4%, P = .009) patients showing an increased IL-6 level: 34 patients with type IIIa (47.2%, P = .0000) and 10 with type IIIb (27.0%, P = .0033). An increased IL-6 level was found in the postmasturbation urine sample in 37 patients (33.9%), irrespective of NIH classification: 28 (38.9%) with type IIIa and 9 (24.3%) with type IIIb. At 6 weeks after therapy, only 3 patients (2.8%, P = .000) had an increased IL-6 level: 2 with type IIIa (2.8%, P = .0000) and 1 with type IIIb (2.7%, P = .02).

CONCLUSIONS

The IL-6 levels had decreased significantly after antibiotic therapy in patients with CP/CPPS, suggesting a bacterial inflammatory character. The determination of IL-6 in seminal plasma and postmasturbation urine samples is useful as an addition to the diagnostic test for the patient with CP/CPPS and as an efficacy marker for therapy.

Authors+Show Affiliations

Department of Urology, Ludwig-Boltzmann Institute for Urology and Andrology, Hospital Hietzing, Vienna, Austria. igor.stancik@wienkav.atNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18468661

Citation

Stancik, Igor, et al. "Effect of Antibiotic Therapy On Interleukin-6 in Fresh Semen and Postmasturbation Urine Samples of Patients With Chronic Prostatitis/chronic Pelvic Pain Syndrome." Urology, vol. 72, no. 2, 2008, pp. 336-9.
Stancik I, Plas E, Juza J, et al. Effect of antibiotic therapy on interleukin-6 in fresh semen and postmasturbation urine samples of patients with chronic prostatitis/chronic pelvic pain syndrome. Urology. 2008;72(2):336-9.
Stancik, I., Plas, E., Juza, J., & Pflüger, H. (2008). Effect of antibiotic therapy on interleukin-6 in fresh semen and postmasturbation urine samples of patients with chronic prostatitis/chronic pelvic pain syndrome. Urology, 72(2), 336-9. https://doi.org/10.1016/j.urology.2008.04.005
Stancik I, et al. Effect of Antibiotic Therapy On Interleukin-6 in Fresh Semen and Postmasturbation Urine Samples of Patients With Chronic Prostatitis/chronic Pelvic Pain Syndrome. Urology. 2008;72(2):336-9. PubMed PMID: 18468661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of antibiotic therapy on interleukin-6 in fresh semen and postmasturbation urine samples of patients with chronic prostatitis/chronic pelvic pain syndrome. AU - Stancik,Igor, AU - Plas,Eugen, AU - Juza,Johanna, AU - Pflüger,Heinz, Y1 - 2008/05/12/ PY - 2007/11/19/received PY - 2008/03/25/revised PY - 2008/04/08/accepted PY - 2008/5/13/pubmed PY - 2008/10/1/medline PY - 2008/5/13/entrez SP - 336 EP - 9 JF - Urology JO - Urology VL - 72 IS - 2 N2 - OBJECTIVES: To investigate the effect of antibiotic therapy on interleukin (IL)-6 in fresh semen and postmasturbation urine samples of patients with chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS). METHODS: A total of 128 patients with CP/CPPS prospectively underwent the evaluation of IL-6 in fresh semen and postmasturbation urine samples. At 6 weeks after 4 weeks antibiotic therapy, the IL-6 levels were re-evaluated. RESULTS: Of the 128 patients, 109 (85.2%) were available for our analysis. Of the 109 patients, 72 (66.1%) met the criteria for National Institutes of Health (NIH) classification for inflammatory CP/CPPS (type IIIa) and 37 (33.9%) met the NIH criteria for noninflammatory CP/CPPS (type IIIb). Before antibiotic therapy, 86 patients (78.9%), irrespective of NIH classification, had an increased IL-6 level in fresh semen; 64 (88.9%) patients with CP/CPPS type IIIa and 22 (59.5%) with type IIIb CP/CPPS had increased IL-6 levels. After 4 weeks of therapy, a significant reduction was found in the IL-6 level, with only 44 (40.4%, P = .009) patients showing an increased IL-6 level: 34 patients with type IIIa (47.2%, P = .0000) and 10 with type IIIb (27.0%, P = .0033). An increased IL-6 level was found in the postmasturbation urine sample in 37 patients (33.9%), irrespective of NIH classification: 28 (38.9%) with type IIIa and 9 (24.3%) with type IIIb. At 6 weeks after therapy, only 3 patients (2.8%, P = .000) had an increased IL-6 level: 2 with type IIIa (2.8%, P = .0000) and 1 with type IIIb (2.7%, P = .02). CONCLUSIONS: The IL-6 levels had decreased significantly after antibiotic therapy in patients with CP/CPPS, suggesting a bacterial inflammatory character. The determination of IL-6 in seminal plasma and postmasturbation urine samples is useful as an addition to the diagnostic test for the patient with CP/CPPS and as an efficacy marker for therapy. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/18468661/Effect_of_antibiotic_therapy_on_interleukin_6_in_fresh_semen_and_postmasturbation_urine_samples_of_patients_with_chronic_prostatitis/chronic_pelvic_pain_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(08)00458-5 DB - PRIME DP - Unbound Medicine ER -