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Glutamine is an important precursor for de novo synthesis of arginine in humans.
Am J Clin Nutr 2008; 87(5):1282-9AJ

Abstract

BACKGROUND

A metabolic relation exists between glutamine and arginine, 2 amino acids with properties that enhance the recovery of seriously ill patients. It is possible that glutamine exerts part of its beneficial effects by enhancing the availability of arginine.

OBJECTIVES

We aimed to quantify under postabsorptive conditions the metabolic pathway of plasma glutamine into arginine via the intermediate citrulline and to establish the contribution of the kidneys to the synthesis of arginine.

DESIGN

The study was conducted in patients during surgery. The metabolism of glutamine, citrulline, and arginine was studied by using intravenous administration of stable isotope tracers of the amino acids. Results were interpreted by using established equations. Parametric tests were used to test and correlate results. P < 0.05 was regarded as significant.

RESULTS

Mean (+/-SE) whole-body plasma turnover rates of glutamine, citrulline, and arginine were 240 +/- 14, 6.2 +/- 0.6, and 42 +/- 2.9 micromol x kg(-1) x h(-1), respectively (P < 0.01). Plasma turnover of citrulline derived from glutamine was shown to be 5.1 +/- 0.7 micromol x kg(-1) x h(-1), and arginine derived from citrulline was shown to be 4.9 +/- 0.9 micromol x kg(-1) x h(-1) (P < 0.01). The contribution of plasma glutamine to plasma arginine derived from plasma citrulline was calculated to be 64%. The kidneys were observed to take up >50% of circulating plasma citrulline and to release equimolar amounts of arginine into plasma.

CONCLUSIONS

This study shows that glutamine is an important precursor for the synthesis of arginine in humans. It also provides a firm basis for future studies exploring the effect of a treatment dose and the route of administration (enteral or parenteral) of glutamine.

Authors+Show Affiliations

Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18469251

Citation

Ligthart-Melis, Gerdien C., et al. "Glutamine Is an Important Precursor for De Novo Synthesis of Arginine in Humans." The American Journal of Clinical Nutrition, vol. 87, no. 5, 2008, pp. 1282-9.
Ligthart-Melis GC, van de Poll MC, Boelens PG, et al. Glutamine is an important precursor for de novo synthesis of arginine in humans. Am J Clin Nutr. 2008;87(5):1282-9.
Ligthart-Melis, G. C., van de Poll, M. C., Boelens, P. G., Dejong, C. H., Deutz, N. E., & van Leeuwen, P. A. (2008). Glutamine is an important precursor for de novo synthesis of arginine in humans. The American Journal of Clinical Nutrition, 87(5), pp. 1282-9.
Ligthart-Melis GC, et al. Glutamine Is an Important Precursor for De Novo Synthesis of Arginine in Humans. Am J Clin Nutr. 2008;87(5):1282-9. PubMed PMID: 18469251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glutamine is an important precursor for de novo synthesis of arginine in humans. AU - Ligthart-Melis,Gerdien C, AU - van de Poll,Marcel C G, AU - Boelens,Petra G, AU - Dejong,Cornelis H C, AU - Deutz,Nicolaas E P, AU - van Leeuwen,Paul A M, PY - 2008/5/13/pubmed PY - 2008/6/12/medline PY - 2008/5/13/entrez SP - 1282 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 87 IS - 5 N2 - BACKGROUND: A metabolic relation exists between glutamine and arginine, 2 amino acids with properties that enhance the recovery of seriously ill patients. It is possible that glutamine exerts part of its beneficial effects by enhancing the availability of arginine. OBJECTIVES: We aimed to quantify under postabsorptive conditions the metabolic pathway of plasma glutamine into arginine via the intermediate citrulline and to establish the contribution of the kidneys to the synthesis of arginine. DESIGN: The study was conducted in patients during surgery. The metabolism of glutamine, citrulline, and arginine was studied by using intravenous administration of stable isotope tracers of the amino acids. Results were interpreted by using established equations. Parametric tests were used to test and correlate results. P < 0.05 was regarded as significant. RESULTS: Mean (+/-SE) whole-body plasma turnover rates of glutamine, citrulline, and arginine were 240 +/- 14, 6.2 +/- 0.6, and 42 +/- 2.9 micromol x kg(-1) x h(-1), respectively (P < 0.01). Plasma turnover of citrulline derived from glutamine was shown to be 5.1 +/- 0.7 micromol x kg(-1) x h(-1), and arginine derived from citrulline was shown to be 4.9 +/- 0.9 micromol x kg(-1) x h(-1) (P < 0.01). The contribution of plasma glutamine to plasma arginine derived from plasma citrulline was calculated to be 64%. The kidneys were observed to take up >50% of circulating plasma citrulline and to release equimolar amounts of arginine into plasma. CONCLUSIONS: This study shows that glutamine is an important precursor for the synthesis of arginine in humans. It also provides a firm basis for future studies exploring the effect of a treatment dose and the route of administration (enteral or parenteral) of glutamine. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18469251/Glutamine_is_an_important_precursor_for_de_novo_synthesis_of_arginine_in_humans_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.5.1282 DB - PRIME DP - Unbound Medicine ER -