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Multivitamin-multimineral supplement use and mammographic breast density.
Am J Clin Nutr. 2008 May; 87(5):1400-4.AJ

Abstract

BACKGROUND

The effect of multivitamin-multimineral supplements on the occurrence of chronic diseases, such as breast cancer, is unclear. Breast density is increasingly used as a biomarker of breast cancer risk.

OBJECTIVE

The present study evaluated the association of multivitamin-multimineral supplement use with breast density.

DESIGN

Premenopausal (n = 777) and postmenopausal (n = 783) women were recruited at the time of screening mammography. Anthropometric measurements were taken at recruitment. Demographic characteristics, behavioral factors, and health conditions were documented by telephone interview. Diet and multivitamin-multimineral and individual vitamin and mineral supplement use were assessed with a self-administered food-frequency questionnaire. Breast density from screening mammograms was measured using a computer-assisted method. Crude and adjusted means in breast density were evaluated according to multivitamin-multimineral supplement use using generalized linear models.

RESULTS

Current multivitamin-multimineral supplement use was reported by 21.7% of women (20.7% and 22.6% of premenopausal and postmenopausal women, respectively). Premenopausal women who were currently using multivitamin-multimineral supplements had higher adjusted mean breast density (45.5%) than past (42.9%) or never (40.2%) users (P for heterogeneity = 0.03, P for trend = 0.009). Of the current users, breast density was not related to duration of multivitamin-multimineral supplement use. In postmenopausal women, multivitamin-multimineral supplement use was not associated with breast density (P for heterogeneity = 0.53, P for trend = 0.40).

CONCLUSION

Regular use of multivitamin-multimineral supplements may be associated with higher mean breast density among premenopausal women. The relations of multivitamin-multimineral supplement use to breast density and breast cancer risk need to be clarified.

Authors+Show Affiliations

Unité de Recherche en Santé des Populations, Centre Hospitalier Affilié Universitaire de Québec, Québec, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18469264

Citation

Bérubé, Sylvie, et al. "Multivitamin-multimineral Supplement Use and Mammographic Breast Density." The American Journal of Clinical Nutrition, vol. 87, no. 5, 2008, pp. 1400-4.
Bérubé S, Diorio C, Brisson J. Multivitamin-multimineral supplement use and mammographic breast density. Am J Clin Nutr. 2008;87(5):1400-4.
Bérubé, S., Diorio, C., & Brisson, J. (2008). Multivitamin-multimineral supplement use and mammographic breast density. The American Journal of Clinical Nutrition, 87(5), 1400-4.
Bérubé S, Diorio C, Brisson J. Multivitamin-multimineral Supplement Use and Mammographic Breast Density. Am J Clin Nutr. 2008;87(5):1400-4. PubMed PMID: 18469264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multivitamin-multimineral supplement use and mammographic breast density. AU - Bérubé,Sylvie, AU - Diorio,Caroline, AU - Brisson,Jacques, PY - 2008/5/13/pubmed PY - 2008/6/12/medline PY - 2008/5/13/entrez SP - 1400 EP - 4 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 87 IS - 5 N2 - BACKGROUND: The effect of multivitamin-multimineral supplements on the occurrence of chronic diseases, such as breast cancer, is unclear. Breast density is increasingly used as a biomarker of breast cancer risk. OBJECTIVE: The present study evaluated the association of multivitamin-multimineral supplement use with breast density. DESIGN: Premenopausal (n = 777) and postmenopausal (n = 783) women were recruited at the time of screening mammography. Anthropometric measurements were taken at recruitment. Demographic characteristics, behavioral factors, and health conditions were documented by telephone interview. Diet and multivitamin-multimineral and individual vitamin and mineral supplement use were assessed with a self-administered food-frequency questionnaire. Breast density from screening mammograms was measured using a computer-assisted method. Crude and adjusted means in breast density were evaluated according to multivitamin-multimineral supplement use using generalized linear models. RESULTS: Current multivitamin-multimineral supplement use was reported by 21.7% of women (20.7% and 22.6% of premenopausal and postmenopausal women, respectively). Premenopausal women who were currently using multivitamin-multimineral supplements had higher adjusted mean breast density (45.5%) than past (42.9%) or never (40.2%) users (P for heterogeneity = 0.03, P for trend = 0.009). Of the current users, breast density was not related to duration of multivitamin-multimineral supplement use. In postmenopausal women, multivitamin-multimineral supplement use was not associated with breast density (P for heterogeneity = 0.53, P for trend = 0.40). CONCLUSION: Regular use of multivitamin-multimineral supplements may be associated with higher mean breast density among premenopausal women. The relations of multivitamin-multimineral supplement use to breast density and breast cancer risk need to be clarified. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18469264/Multivitamin_multimineral_supplement_use_and_mammographic_breast_density_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.5.1400 DB - PRIME DP - Unbound Medicine ER -