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Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition.
Am J Clin Nutr. 2008 May; 87(5):1405-13.AJ

Abstract

BACKGROUND

Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear.

OBJECTIVE

The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk.

DESIGN

This was a multicenter prospective study of 142,520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake.

RESULTS

After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish.

CONCLUSION

The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk.

Authors+Show Affiliations

Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom. francesca.crowe@ceu.ox.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18469265

Citation

Crowe, Francesca L., et al. "Dietary Fat Intake and Risk of Prostate Cancer in the European Prospective Investigation Into Cancer and Nutrition." The American Journal of Clinical Nutrition, vol. 87, no. 5, 2008, pp. 1405-13.
Crowe FL, Key TJ, Appleby PN, et al. Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr. 2008;87(5):1405-13.
Crowe, F. L., Key, T. J., Appleby, P. N., Travis, R. C., Overvad, K., Jakobsen, M. U., Johnsen, N. F., Tjønneland, A., Linseisen, J., Rohrmann, S., Boeing, H., Pischon, T., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Sacerdote, C., Palli, D., Tumino, R., Krogh, V., ... Riboli, E. (2008). Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. The American Journal of Clinical Nutrition, 87(5), 1405-13.
Crowe FL, et al. Dietary Fat Intake and Risk of Prostate Cancer in the European Prospective Investigation Into Cancer and Nutrition. Am J Clin Nutr. 2008;87(5):1405-13. PubMed PMID: 18469265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. AU - Crowe,Francesca L, AU - Key,Timothy J, AU - Appleby,Paul N, AU - Travis,Ruth C, AU - Overvad,Kim, AU - Jakobsen,Marianne U, AU - Johnsen,Nina F, AU - Tjønneland,Anne, AU - Linseisen,Jakob, AU - Rohrmann,Sabine, AU - Boeing,Heiner, AU - Pischon,Tobias, AU - Trichopoulou,Antonia, AU - Lagiou,Pagona, AU - Trichopoulos,Dimitrios, AU - Sacerdote,Carlotta, AU - Palli,Domenico, AU - Tumino,Rosario, AU - Krogh,Vitorrio, AU - Bueno-de-Mesquita,H Bas, AU - Kiemeney,Lambertus A, AU - Chirlaque,Maria-Dolores, AU - Ardanaz,Eva, AU - Sánchez,Maria-José, AU - Larrañaga,Nerea, AU - González,Carlos A, AU - Quirós,José R, AU - Manjer,Jonas, AU - Wirfält,Elisabet, AU - Stattin,Pär, AU - Hallmans,Göran, AU - Khaw,Kay-Tee, AU - Bingham,Sheila, AU - Ferrari,Pietro, AU - Slimani,Nadia, AU - Jenab,Mazda, AU - Riboli,Elio, PY - 2008/5/13/pubmed PY - 2008/6/12/medline PY - 2008/5/13/entrez SP - 1405 EP - 13 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 87 IS - 5 N2 - BACKGROUND: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. OBJECTIVE: The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk. DESIGN: This was a multicenter prospective study of 142,520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake. RESULTS: After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish. CONCLUSION: The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18469265/Dietary_fat_intake_and_risk_of_prostate_cancer_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.5.1405 DB - PRIME DP - Unbound Medicine ER -