Tags

Type your tag names separated by a space and hit enter

Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer.
Am J Clin Nutr 2008; 87(5):1428-38AJ

Abstract

BACKGROUND

Acrylamide, a probable human carcinogen, was recently detected in various heat-treated carbohydrate-rich foods. Epidemiologic studies on the relation with cancer have been few and largely negative.

OBJECTIVE

We aimed to prospectively examine the association between dietary acrylamide intake and renal cell, bladder, and prostate cancers.

DESIGN

The Netherlands Cohort Study on diet and cancer includes 120,852 men and women aged 55-69 y. At baseline (1986), a random subcohort of 5000 participants was selected for a case-cohort analysis approach using Cox proportional hazards analysis. Acrylamide intake was assessed with a food-frequency questionnaire at baseline and was based on chemical analysis of all relevant Dutch foods.

RESULTS

After 13.3 y of follow-up, 339, 1210, and 2246 cases of renal cell, bladder, and prostate cancer, respectively, were available for analysis. Compared with the lowest quintile of acrylamide intake (mean intake: 9.5 microg/d), multivariable-adjusted hazard rates for renal cell, bladder, and prostate cancer in the highest quintile (mean intake: 40.8 microg/d) were 1.59 (95% CI: 1.09, 2.30; P for trend = 0.04), 0.91 (95% CI: 0.73, 1.15; P for trend = 0.60), and 1.06 (95% CI: 0.87, 1.30; P for trend = 0.69), respectively. There was an inverse nonsignificant trend for advanced prostate cancer in never smokers.

CONCLUSIONS

We found some indications for a positive association between dietary acrylamide and renal cell cancer risk. There were no positive associations with bladder and prostate cancer risk.

Authors+Show Affiliations

Department of Epidemiology, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands. jgf.hogervorst@epid.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18469268

Citation

Hogervorst, Janneke G., et al. "Dietary Acrylamide Intake and the Risk of Renal Cell, Bladder, and Prostate Cancer." The American Journal of Clinical Nutrition, vol. 87, no. 5, 2008, pp. 1428-38.
Hogervorst JG, Schouten LJ, Konings EJ, et al. Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer. Am J Clin Nutr. 2008;87(5):1428-38.
Hogervorst, J. G., Schouten, L. J., Konings, E. J., Goldbohm, R. A., & van den Brandt, P. A. (2008). Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer. The American Journal of Clinical Nutrition, 87(5), pp. 1428-38.
Hogervorst JG, et al. Dietary Acrylamide Intake and the Risk of Renal Cell, Bladder, and Prostate Cancer. Am J Clin Nutr. 2008;87(5):1428-38. PubMed PMID: 18469268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer. AU - Hogervorst,Janneke G, AU - Schouten,Leo J, AU - Konings,Erik J, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, PY - 2008/5/13/pubmed PY - 2008/6/12/medline PY - 2008/5/13/entrez SP - 1428 EP - 38 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 87 IS - 5 N2 - BACKGROUND: Acrylamide, a probable human carcinogen, was recently detected in various heat-treated carbohydrate-rich foods. Epidemiologic studies on the relation with cancer have been few and largely negative. OBJECTIVE: We aimed to prospectively examine the association between dietary acrylamide intake and renal cell, bladder, and prostate cancers. DESIGN: The Netherlands Cohort Study on diet and cancer includes 120,852 men and women aged 55-69 y. At baseline (1986), a random subcohort of 5000 participants was selected for a case-cohort analysis approach using Cox proportional hazards analysis. Acrylamide intake was assessed with a food-frequency questionnaire at baseline and was based on chemical analysis of all relevant Dutch foods. RESULTS: After 13.3 y of follow-up, 339, 1210, and 2246 cases of renal cell, bladder, and prostate cancer, respectively, were available for analysis. Compared with the lowest quintile of acrylamide intake (mean intake: 9.5 microg/d), multivariable-adjusted hazard rates for renal cell, bladder, and prostate cancer in the highest quintile (mean intake: 40.8 microg/d) were 1.59 (95% CI: 1.09, 2.30; P for trend = 0.04), 0.91 (95% CI: 0.73, 1.15; P for trend = 0.60), and 1.06 (95% CI: 0.87, 1.30; P for trend = 0.69), respectively. There was an inverse nonsignificant trend for advanced prostate cancer in never smokers. CONCLUSIONS: We found some indications for a positive association between dietary acrylamide and renal cell cancer risk. There were no positive associations with bladder and prostate cancer risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18469268/Dietary_acrylamide_intake_and_the_risk_of_renal_cell_bladder_and_prostate_cancer_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.5.1428 DB - PRIME DP - Unbound Medicine ER -