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A cohort study of traffic-related air pollution impacts on birth outcomes.
Environ Health Perspect. 2008 May; 116(5):680-6.EH

Abstract

BACKGROUND

Evidence suggests that air pollution exposure adversely affects pregnancy outcomes. Few studies have examined individual-level intraurban exposure contrasts.

OBJECTIVES

We evaluated the impacts of air pollution on small for gestational age (SGA) birth weight, low full-term birth weight (LBW), and preterm birth using spatiotemporal exposure metrics.

METHODS

With linked administrative data, we identified 70,249 singleton births (1999-2002) with complete covariate data (sex, ethnicity, parity, birth month and year, income, education) and maternal residential history in Vancouver, British Columbia, Canada. We estimated residential exposures by month of pregnancy using nearest and inverse-distance weighting (IDW) of study area monitors [carbon monoxide, nitrogen dioxide, nitric oxide, ozone, sulfur dioxide, and particulate matter < 2.5 (PM2.5) or < 10 (PM10) microm in aerodynamic diameter], temporally adjusted land use regression (LUR) models (NO, NO2, PM2.5, black carbon), and proximity to major roads. Using logistic regression, we estimated the risk of mean (entire pregnancy, first and last month of pregnancy, first and last 3 months) air pollution concentrations on SGA (< 10th percentile), term LBW (< 2,500 g), and preterm birth.

RESULTS

Residence within 50 m of highways was associated with a 22% (95% CI, 0.81-1.87) [corrected] increase in LBW. Exposure to all air pollutants except O3 was associated with SGA, with similar odds ratios (ORs) for LUR and monitoring estimates (e.g., LUR: OR = 1.02; 95% CI, 1.00-1.04; IDW: OR = 1.05; 95% CI, 1.03-1.08 per 10-microg/m3 increase in NO). For preterm births, associations were observed with PM2.5 for births < 37 weeks gestation (and for other pollutants at < 30 weeks). No consistent patterns suggested exposure windows of greater relevance.

CONCLUSION

Associations between traffic-related air pollution and birth outcomes were observed in a population-based cohort with relatively low ambient air pollution exposure.

Authors+Show Affiliations

School of Environmental Health, The University of British Columbia, 2206 East Mall, Vancouver BC V6T1Z3 Canada. brauer@interchange.ubc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18470315

Citation

Brauer, Michael, et al. "A Cohort Study of Traffic-related Air Pollution Impacts On Birth Outcomes." Environmental Health Perspectives, vol. 116, no. 5, 2008, pp. 680-6.
Brauer M, Lencar C, Tamburic L, et al. A cohort study of traffic-related air pollution impacts on birth outcomes. Environ Health Perspect. 2008;116(5):680-6.
Brauer, M., Lencar, C., Tamburic, L., Koehoorn, M., Demers, P., & Karr, C. (2008). A cohort study of traffic-related air pollution impacts on birth outcomes. Environmental Health Perspectives, 116(5), 680-6. https://doi.org/10.1289/ehp.10952
Brauer M, et al. A Cohort Study of Traffic-related Air Pollution Impacts On Birth Outcomes. Environ Health Perspect. 2008;116(5):680-6. PubMed PMID: 18470315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cohort study of traffic-related air pollution impacts on birth outcomes. AU - Brauer,Michael, AU - Lencar,Cornel, AU - Tamburic,Lillian, AU - Koehoorn,Mieke, AU - Demers,Paul, AU - Karr,Catherine, PY - 2007/10/04/received PY - 2008/01/22/accepted PY - 2008/5/13/pubmed PY - 2008/9/26/medline PY - 2008/5/13/entrez KW - air pollution KW - birth weight KW - carbon black KW - carbon monoxide KW - nitric oxide KW - nitrogen dioxide KW - particulate matter KW - pregnancy KW - pregnancy outcome KW - preterm birth KW - soot KW - sulfur dioxide KW - vehicle emissions SP - 680 EP - 6 JF - Environmental health perspectives JO - Environ. Health Perspect. VL - 116 IS - 5 N2 - BACKGROUND: Evidence suggests that air pollution exposure adversely affects pregnancy outcomes. Few studies have examined individual-level intraurban exposure contrasts. OBJECTIVES: We evaluated the impacts of air pollution on small for gestational age (SGA) birth weight, low full-term birth weight (LBW), and preterm birth using spatiotemporal exposure metrics. METHODS: With linked administrative data, we identified 70,249 singleton births (1999-2002) with complete covariate data (sex, ethnicity, parity, birth month and year, income, education) and maternal residential history in Vancouver, British Columbia, Canada. We estimated residential exposures by month of pregnancy using nearest and inverse-distance weighting (IDW) of study area monitors [carbon monoxide, nitrogen dioxide, nitric oxide, ozone, sulfur dioxide, and particulate matter < 2.5 (PM2.5) or < 10 (PM10) microm in aerodynamic diameter], temporally adjusted land use regression (LUR) models (NO, NO2, PM2.5, black carbon), and proximity to major roads. Using logistic regression, we estimated the risk of mean (entire pregnancy, first and last month of pregnancy, first and last 3 months) air pollution concentrations on SGA (< 10th percentile), term LBW (< 2,500 g), and preterm birth. RESULTS: Residence within 50 m of highways was associated with a 22% (95% CI, 0.81-1.87) [corrected] increase in LBW. Exposure to all air pollutants except O3 was associated with SGA, with similar odds ratios (ORs) for LUR and monitoring estimates (e.g., LUR: OR = 1.02; 95% CI, 1.00-1.04; IDW: OR = 1.05; 95% CI, 1.03-1.08 per 10-microg/m3 increase in NO). For preterm births, associations were observed with PM2.5 for births < 37 weeks gestation (and for other pollutants at < 30 weeks). No consistent patterns suggested exposure windows of greater relevance. CONCLUSION: Associations between traffic-related air pollution and birth outcomes were observed in a population-based cohort with relatively low ambient air pollution exposure. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/18470315/A_cohort_study_of_traffic_related_air_pollution_impacts_on_birth_outcomes_ L2 - https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.10952?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -