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Determinants of bone turnover markers in healthy premenopausal women.
Calcif Tissue Int 2008; 82(5):341-7CT

Abstract

Bone turnover markers (BTMs) are widely used for the management of osteoporosis, and the premenopausal reference range is the target value for the treatment of postmenopausal osteoporosis with antiresorbing agents. Three serum BTMs (serum C-telopeptide of type I collagen [CTX], osteocalcin [OC], and N-terminal propeptide of type I procollagen [P1NP]), serum calcium, creatinine, phosphate, magnesium, and follicle-stimulating hormone (FSH) were measured in 638 healthy premenopausal women aged 20-50 years. In 83 women on the contraceptive pill (CP), the levels of the three BTMs adjusted for all confounding factors were 14-26% lower (P < 0.005) than in non-CP users. In 18 women considered perimenopausal for serum FSH levels >30 IU/mL despite having regular menses, BTM levels were significantly higher than in age-matched women. This group of subjects and the women on the CP were excluded from further analysis. The three BTMs significantly decreased with advancing age and were negatively and independently correlated with body mass index (P < 0.001) and serum phosphate. In conclusion, we confirm that CP use is associated with significantly lower BTM values. An increase in BTM concentrations can be observed in perimenopausal women, i.e., women with normal menses but FSH levels >30 IU/mL. BTMs decrease substantially with advancing age, and this appears to be associated with changes in body weight and serum phosphate. New normative ranges for serum OC, CTX, and P1NP were identified; and our findings in general impose a redefinition of the criteria for establishing the normal ranges for BTMs.

Authors+Show Affiliations

Rheumatology Unit, University of Verona, Ospedale di Valeggio, Valeggio, Verona, Italy. silvano.adami@univr.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18470550

Citation

Adami, Silvano, et al. "Determinants of Bone Turnover Markers in Healthy Premenopausal Women." Calcified Tissue International, vol. 82, no. 5, 2008, pp. 341-7.
Adami S, Bianchi G, Brandi ML, et al. Determinants of bone turnover markers in healthy premenopausal women. Calcif Tissue Int. 2008;82(5):341-7.
Adami, S., Bianchi, G., Brandi, M. L., Giannini, S., Ortolani, S., DiMunno, O., ... Rossini, M. (2008). Determinants of bone turnover markers in healthy premenopausal women. Calcified Tissue International, 82(5), pp. 341-7. doi:10.1007/s00223-008-9126-5.
Adami S, et al. Determinants of Bone Turnover Markers in Healthy Premenopausal Women. Calcif Tissue Int. 2008;82(5):341-7. PubMed PMID: 18470550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determinants of bone turnover markers in healthy premenopausal women. AU - Adami,Silvano, AU - Bianchi,Gerolamo, AU - Brandi,Maria Luisa, AU - Giannini,Sandro, AU - Ortolani,Sergio, AU - DiMunno,Ombretta, AU - Frediani,Bruno, AU - Rossini,Maurizio, AU - ,, Y1 - 2008/05/10/ PY - 2008/02/26/received PY - 2008/03/12/accepted PY - 2008/5/13/pubmed PY - 2008/8/22/medline PY - 2008/5/13/entrez SP - 341 EP - 7 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 82 IS - 5 N2 - Bone turnover markers (BTMs) are widely used for the management of osteoporosis, and the premenopausal reference range is the target value for the treatment of postmenopausal osteoporosis with antiresorbing agents. Three serum BTMs (serum C-telopeptide of type I collagen [CTX], osteocalcin [OC], and N-terminal propeptide of type I procollagen [P1NP]), serum calcium, creatinine, phosphate, magnesium, and follicle-stimulating hormone (FSH) were measured in 638 healthy premenopausal women aged 20-50 years. In 83 women on the contraceptive pill (CP), the levels of the three BTMs adjusted for all confounding factors were 14-26% lower (P < 0.005) than in non-CP users. In 18 women considered perimenopausal for serum FSH levels >30 IU/mL despite having regular menses, BTM levels were significantly higher than in age-matched women. This group of subjects and the women on the CP were excluded from further analysis. The three BTMs significantly decreased with advancing age and were negatively and independently correlated with body mass index (P < 0.001) and serum phosphate. In conclusion, we confirm that CP use is associated with significantly lower BTM values. An increase in BTM concentrations can be observed in perimenopausal women, i.e., women with normal menses but FSH levels >30 IU/mL. BTMs decrease substantially with advancing age, and this appears to be associated with changes in body weight and serum phosphate. New normative ranges for serum OC, CTX, and P1NP were identified; and our findings in general impose a redefinition of the criteria for establishing the normal ranges for BTMs. SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/18470550/Determinants_of_bone_turnover_markers_in_healthy_premenopausal_women_ L2 - https://dx.doi.org/10.1007/s00223-008-9126-5 DB - PRIME DP - Unbound Medicine ER -