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Silica exposure, silicosis, and lung cancer: a mortality study of South African gold miners.
Br J Ind Med 1991; 48(1):53-60BJ

Abstract

The effects of exposure to gold mining dust with a high concentration of free silica and tobacco smoking on mortality from lung cancer was assessed in a sample of 2209 white South African gold miners who started mining exposure during 1936-43, and were selected for a study of respiratory disorders in 1968-71 when they were aged 45-54. The mortality follow up was from 1968-71 to 30 December 1986. The relative risk for the effect of dust cumulated to the start of the follow up period was estimated as 1.023 (95% confidence interval (CI) 1.005-1.042) for a unit of 1000 particle-years. The combined effect of dust and tobacco smoking was better fitted by the multiplicative model than the additive model, suggesting that the two exposures act synergistically. No association between lung cancer and silicosis of the parenchyma or pleura was found, but a positive association existed between silicosis of the hilar glands and lung cancer.

Authors+Show Affiliations

Epidemiology Research Unit, Medical Bureau for Occupational Diseases, Johannesburg, South Africa.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1847069

Citation

Hnizdo, E, and G K. Sluis-Cremer. "Silica Exposure, Silicosis, and Lung Cancer: a Mortality Study of South African Gold Miners." British Journal of Industrial Medicine, vol. 48, no. 1, 1991, pp. 53-60.
Hnizdo E, Sluis-Cremer GK. Silica exposure, silicosis, and lung cancer: a mortality study of South African gold miners. Br J Ind Med. 1991;48(1):53-60.
Hnizdo, E., & Sluis-Cremer, G. K. (1991). Silica exposure, silicosis, and lung cancer: a mortality study of South African gold miners. British Journal of Industrial Medicine, 48(1), pp. 53-60.
Hnizdo E, Sluis-Cremer GK. Silica Exposure, Silicosis, and Lung Cancer: a Mortality Study of South African Gold Miners. Br J Ind Med. 1991;48(1):53-60. PubMed PMID: 1847069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Silica exposure, silicosis, and lung cancer: a mortality study of South African gold miners. AU - Hnizdo,E, AU - Sluis-Cremer,G K, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 53 EP - 60 JF - British journal of industrial medicine JO - Br J Ind Med VL - 48 IS - 1 N2 - The effects of exposure to gold mining dust with a high concentration of free silica and tobacco smoking on mortality from lung cancer was assessed in a sample of 2209 white South African gold miners who started mining exposure during 1936-43, and were selected for a study of respiratory disorders in 1968-71 when they were aged 45-54. The mortality follow up was from 1968-71 to 30 December 1986. The relative risk for the effect of dust cumulated to the start of the follow up period was estimated as 1.023 (95% confidence interval (CI) 1.005-1.042) for a unit of 1000 particle-years. The combined effect of dust and tobacco smoking was better fitted by the multiplicative model than the additive model, suggesting that the two exposures act synergistically. No association between lung cancer and silicosis of the parenchyma or pleura was found, but a positive association existed between silicosis of the hilar glands and lung cancer. SN - 0007-1072 UR - https://www.unboundmedicine.com/medline/citation/1847069/Silica_exposure_silicosis_and_lung_cancer:_a_mortality_study_of_South_African_gold_miners_ L2 - http://oem.bmj.com/cgi/pmidlookup?view=long&pmid=1847069 DB - PRIME DP - Unbound Medicine ER -