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Determination of iodoacetic acid using liquid chromatography/electrospray tandem mass spectrometry.
Rapid Commun Mass Spectrom. 2008 Jun; 22(12):1787-91.RC

Abstract

A rapid analytical method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) using electrospray ionization in negative ion detection mode was developed for the analysis of underivatized iodoacetic acid in water. The method was applied to model reaction mixtures in the study of the formation of iodoacetic acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt. Samples can be directly analyzed by the LC/MS/MS system without extraction or chemical derivatization. Limit of detection was determined to be 0.3 microg/L (or 0.3 ng/mL) and limit of quantitation was about 1 microg/L (1 ng/mL).

Authors+Show Affiliations

Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada, K1A 0K9. ben_lau@hc-sc.gc.caNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18470871

Citation

Lau, Benjamin P-Y, and Adam Becalski. "Determination of Iodoacetic Acid Using Liquid Chromatography/electrospray Tandem Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 22, no. 12, 2008, pp. 1787-91.
Lau BP, Becalski A. Determination of iodoacetic acid using liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008;22(12):1787-91.
Lau, B. P., & Becalski, A. (2008). Determination of iodoacetic acid using liquid chromatography/electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 22(12), 1787-91. https://doi.org/10.1002/rcm.3547
Lau BP, Becalski A. Determination of Iodoacetic Acid Using Liquid Chromatography/electrospray Tandem Mass Spectrometry. Rapid Commun Mass Spectrom. 2008;22(12):1787-91. PubMed PMID: 18470871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of iodoacetic acid using liquid chromatography/electrospray tandem mass spectrometry. AU - Lau,Benjamin P-Y, AU - Becalski,Adam, PY - 2008/5/13/pubmed PY - 2008/7/24/medline PY - 2008/5/13/entrez SP - 1787 EP - 91 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 22 IS - 12 N2 - A rapid analytical method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) using electrospray ionization in negative ion detection mode was developed for the analysis of underivatized iodoacetic acid in water. The method was applied to model reaction mixtures in the study of the formation of iodoacetic acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt. Samples can be directly analyzed by the LC/MS/MS system without extraction or chemical derivatization. Limit of detection was determined to be 0.3 microg/L (or 0.3 ng/mL) and limit of quantitation was about 1 microg/L (1 ng/mL). SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/18470871/Determination_of_iodoacetic_acid_using_liquid_chromatography/electrospray_tandem_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.3547 DB - PRIME DP - Unbound Medicine ER -