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New features on the fragmentation and differentiation of C-glycosidic flavone isomers by positive electrospray ionization and triple quadrupole mass spectrometry.
Rapid Commun Mass Spectrom. 2008 Jun; 22(12):1834-42.RC

Abstract

Six flavone mono-C-glucosides, four standards (beta-D-glucopyranosyl-(1 --> C-6)- and -(1 --> C-8)- apigenin and luteolin) and two others from lemon juice (beta-D-glucopyranosyl-(1 --> C-6)- and -(1 --> C-8)-diosmetin) have been studied in order to analyze their fragmentation patterns. Initial separation was carried out using high-performance liquid chromatography with diode-array detection (HPLC/DAD) coupled to an electrospray ionization (ESI) interface and a triple quadrupole mass spectrometer. Several systematic differences between collision-induced dissociation tandem mass (CID-MS/MS) spectra of C-6- and C-8-isomers have been found and some general guidelines and two new diagnostic product ions have been proposed for the differentiation of C-6- and C-8-flavonoid glycosides. These results have been successfully applied to the characterization of two flavone C-glycosides found in lemon juice, and mass spectra of a flavone di-C-glycoside detected in lemon juice have been studied and interpreted.

Authors+Show Affiliations

Departamento de Quimica Analitica, Facultad de Ciencia y Tecnologia, Universidad del Pais Vasco, 48080 Bilbao, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18470889

Citation

Abad-García, Beatriz, et al. "New Features On the Fragmentation and Differentiation of C-glycosidic Flavone Isomers By Positive Electrospray Ionization and Triple Quadrupole Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 22, no. 12, 2008, pp. 1834-42.
Abad-García B, Garmón-Lobato S, Berrueta LA, et al. New features on the fragmentation and differentiation of C-glycosidic flavone isomers by positive electrospray ionization and triple quadrupole mass spectrometry. Rapid Commun Mass Spectrom. 2008;22(12):1834-42.
Abad-García, B., Garmón-Lobato, S., Berrueta, L. A., Gallo, B., & Vicente, F. (2008). New features on the fragmentation and differentiation of C-glycosidic flavone isomers by positive electrospray ionization and triple quadrupole mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 22(12), 1834-42. https://doi.org/10.1002/rcm.3560
Abad-García B, et al. New Features On the Fragmentation and Differentiation of C-glycosidic Flavone Isomers By Positive Electrospray Ionization and Triple Quadrupole Mass Spectrometry. Rapid Commun Mass Spectrom. 2008;22(12):1834-42. PubMed PMID: 18470889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New features on the fragmentation and differentiation of C-glycosidic flavone isomers by positive electrospray ionization and triple quadrupole mass spectrometry. AU - Abad-García,Beatriz, AU - Garmón-Lobato,Sergio, AU - Berrueta,Luis A, AU - Gallo,Blanca, AU - Vicente,Francisca, PY - 2008/5/13/pubmed PY - 2008/7/24/medline PY - 2008/5/13/entrez SP - 1834 EP - 42 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 22 IS - 12 N2 - Six flavone mono-C-glucosides, four standards (beta-D-glucopyranosyl-(1 --> C-6)- and -(1 --> C-8)- apigenin and luteolin) and two others from lemon juice (beta-D-glucopyranosyl-(1 --> C-6)- and -(1 --> C-8)-diosmetin) have been studied in order to analyze their fragmentation patterns. Initial separation was carried out using high-performance liquid chromatography with diode-array detection (HPLC/DAD) coupled to an electrospray ionization (ESI) interface and a triple quadrupole mass spectrometer. Several systematic differences between collision-induced dissociation tandem mass (CID-MS/MS) spectra of C-6- and C-8-isomers have been found and some general guidelines and two new diagnostic product ions have been proposed for the differentiation of C-6- and C-8-flavonoid glycosides. These results have been successfully applied to the characterization of two flavone C-glycosides found in lemon juice, and mass spectra of a flavone di-C-glycoside detected in lemon juice have been studied and interpreted. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/18470889/New_features_on_the_fragmentation_and_differentiation_of_C_glycosidic_flavone_isomers_by_positive_electrospray_ionization_and_triple_quadrupole_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.3560 DB - PRIME DP - Unbound Medicine ER -