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Immunophenotypical characterization of monocytes in canine distemper virus infection.
Vet Microbiol. 2008 Oct 15; 131(3-4):237-46.VM

Abstract

Canine distemper virus (CDV) infection induces multifocal demyelination in the central nervous system (CNS). It is thought that the resident macrophages of the CNS, the microglia, as well as invading monocytes associated with the inflammatory reaction may play a central role in the demyelinating process. To evaluate changes in peripheral monocytes in CDV infection their immunophenotype was characterized by flow cytometry during the course of an experimental CDV infection in dogs. The highest number of CDV-infected monocytes was found in dogs developing demyelinating lesions. In CD18, CD45, CD44, and CD14 neither up- nor down-regulation was observed. Marked up-regulation occurred in a number of surface molecules including CD1c, B7-1 and B7-2, MHC I, and CD11b. Peak expression was found at 4-5 weeks post-infection (PI), regardless of clinical outcome. All these molecules play an important role in the host's immune response, notably antigen presentation and cell adhesion. These results demonstrate that CDV infection in vivo may enhance several macrophage functions. This could lead to more effective clearance of the virus but may also increase demyelination through a bystander effect in animals that accumulated significant amounts of CDV in the CNS.

Authors+Show Affiliations

Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, D-30173 Hannover, Germany. Veronika.Stein@tiho-hannover.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18472370

Citation

Stein, Veronika M., et al. "Immunophenotypical Characterization of Monocytes in Canine Distemper Virus Infection." Veterinary Microbiology, vol. 131, no. 3-4, 2008, pp. 237-46.
Stein VM, Schreiner NM, Moore PF, et al. Immunophenotypical characterization of monocytes in canine distemper virus infection. Vet Microbiol. 2008;131(3-4):237-46.
Stein, V. M., Schreiner, N. M., Moore, P. F., Vandevelde, M., Zurbriggen, A., & Tipold, A. (2008). Immunophenotypical characterization of monocytes in canine distemper virus infection. Veterinary Microbiology, 131(3-4), 237-46. https://doi.org/10.1016/j.vetmic.2008.03.009
Stein VM, et al. Immunophenotypical Characterization of Monocytes in Canine Distemper Virus Infection. Vet Microbiol. 2008 Oct 15;131(3-4):237-46. PubMed PMID: 18472370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunophenotypical characterization of monocytes in canine distemper virus infection. AU - Stein,Veronika M, AU - Schreiner,Nicole M S, AU - Moore,Peter F, AU - Vandevelde,Marc, AU - Zurbriggen,Andreas, AU - Tipold,Andrea, Y1 - 2008/04/01/ PY - 2008/01/08/received PY - 2008/03/17/revised PY - 2008/03/19/accepted PY - 2008/5/13/pubmed PY - 2008/12/17/medline PY - 2008/5/13/entrez SP - 237 EP - 46 JF - Veterinary microbiology JO - Vet. Microbiol. VL - 131 IS - 3-4 N2 - Canine distemper virus (CDV) infection induces multifocal demyelination in the central nervous system (CNS). It is thought that the resident macrophages of the CNS, the microglia, as well as invading monocytes associated with the inflammatory reaction may play a central role in the demyelinating process. To evaluate changes in peripheral monocytes in CDV infection their immunophenotype was characterized by flow cytometry during the course of an experimental CDV infection in dogs. The highest number of CDV-infected monocytes was found in dogs developing demyelinating lesions. In CD18, CD45, CD44, and CD14 neither up- nor down-regulation was observed. Marked up-regulation occurred in a number of surface molecules including CD1c, B7-1 and B7-2, MHC I, and CD11b. Peak expression was found at 4-5 weeks post-infection (PI), regardless of clinical outcome. All these molecules play an important role in the host's immune response, notably antigen presentation and cell adhesion. These results demonstrate that CDV infection in vivo may enhance several macrophage functions. This could lead to more effective clearance of the virus but may also increase demyelination through a bystander effect in animals that accumulated significant amounts of CDV in the CNS. SN - 0378-1135 UR - https://www.unboundmedicine.com/medline/citation/18472370/Immunophenotypical_characterization_of_monocytes_in_canine_distemper_virus_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(08)00109-0 DB - PRIME DP - Unbound Medicine ER -