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Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD.
Nutr Metab Cardiovasc Dis. 2009 Jan; 19(1):54-60.NM

Abstract

BACKGROUND AND AIMS

Total adiponectin is emerging as an independent risk factor for cardiovascular diseases, but the role of adiponectin isoforms in coronary artery disease (CAD) is still unknown. We investigated the role of adiponectin isoforms with respect to the severity of coronary disease and to the presence of undiagnosed diabetes in patients with CAD.

METHODS AND RESULTS

We recruited 205 CAD patients, all living in the central area of Italy, with a history of a previous myocardial infarction but apparently not affected by type 2 diabetes (DM2). We compared the CAD patients to a control population (n=100) matched for age, sex, BMI and cardiovascular risk factors, but without overt diabetes and cardiovascular disease. In all patients we measured Total Adiponectin (Tot-Ad) and its isoforms, metabolic, pro- and anti-inflammatory markers and we performed an oral glucose tolerance test (OGTT). CAD patients underwent a coronary angiography and/or coronary multi-slice computed tomography. Based on the severity of CAD they were divided into mono-vessel versus multi-vessel patients. Tot-Ad levels and its isoforms were comparable in patients with mono-vessel versus multi-vessel CAD. After the OGTT, in CAD patients, the results showed that 19% of patients were affected by unknown DM2, 36.1% by unknown impaired glucose tolerance (IGT), and only 43.9% were truly normoglycemic (NGT). Low levels of high molecular weight-adiponectin (HMW-Ad) were significantly associated with undiagnosed IGT or DM2 status (p<0.01).

CONCLUSIONS

In our cohort of CAD patients, Tot-Ad and its isoforms do not correlate with severity of CAD, but with undiagnosed defects of glucose metabolism.

Authors+Show Affiliations

Center for Atherosclerosis, University of Rome Tor Vergata, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18472407

Citation

Rizza, Stefano, et al. "Adiponectin Isoforms Are Not Associated With the Severity of Coronary Atherosclerosis but With Undiagnosed Diabetes in Patients Affected By Stable CAD." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 19, no. 1, 2009, pp. 54-60.
Rizza S, Clementi F, Porzio O, et al. Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD. Nutr Metab Cardiovasc Dis. 2009;19(1):54-60.
Rizza, S., Clementi, F., Porzio, O., Cardellini, M., Savo, A., Serino, M., Chiricolo, G., Romeo, F., Lauro, R., & Federici, M. (2009). Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 19(1), 54-60. https://doi.org/10.1016/j.numecd.2007.12.001
Rizza S, et al. Adiponectin Isoforms Are Not Associated With the Severity of Coronary Atherosclerosis but With Undiagnosed Diabetes in Patients Affected By Stable CAD. Nutr Metab Cardiovasc Dis. 2009;19(1):54-60. PubMed PMID: 18472407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD. AU - Rizza,Stefano, AU - Clementi,Fabrizio, AU - Porzio,Ottavia, AU - Cardellini,Marina, AU - Savo,Alessia, AU - Serino,Matteo, AU - Chiricolo,Gaetano, AU - Romeo,Francesco, AU - Lauro,Renato, AU - Federici,Massimo, Y1 - 2008/05/09/ PY - 2007/06/26/received PY - 2007/11/26/revised PY - 2007/12/02/accepted PY - 2008/5/13/pubmed PY - 2009/3/6/medline PY - 2008/5/13/entrez SP - 54 EP - 60 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 19 IS - 1 N2 - BACKGROUND AND AIMS: Total adiponectin is emerging as an independent risk factor for cardiovascular diseases, but the role of adiponectin isoforms in coronary artery disease (CAD) is still unknown. We investigated the role of adiponectin isoforms with respect to the severity of coronary disease and to the presence of undiagnosed diabetes in patients with CAD. METHODS AND RESULTS: We recruited 205 CAD patients, all living in the central area of Italy, with a history of a previous myocardial infarction but apparently not affected by type 2 diabetes (DM2). We compared the CAD patients to a control population (n=100) matched for age, sex, BMI and cardiovascular risk factors, but without overt diabetes and cardiovascular disease. In all patients we measured Total Adiponectin (Tot-Ad) and its isoforms, metabolic, pro- and anti-inflammatory markers and we performed an oral glucose tolerance test (OGTT). CAD patients underwent a coronary angiography and/or coronary multi-slice computed tomography. Based on the severity of CAD they were divided into mono-vessel versus multi-vessel patients. Tot-Ad levels and its isoforms were comparable in patients with mono-vessel versus multi-vessel CAD. After the OGTT, in CAD patients, the results showed that 19% of patients were affected by unknown DM2, 36.1% by unknown impaired glucose tolerance (IGT), and only 43.9% were truly normoglycemic (NGT). Low levels of high molecular weight-adiponectin (HMW-Ad) were significantly associated with undiagnosed IGT or DM2 status (p<0.01). CONCLUSIONS: In our cohort of CAD patients, Tot-Ad and its isoforms do not correlate with severity of CAD, but with undiagnosed defects of glucose metabolism. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/18472407/Adiponectin_isoforms_are_not_associated_with_the_severity_of_coronary_atherosclerosis_but_with_undiagnosed_diabetes_in_patients_affected_by_stable_CAD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(07)00222-0 DB - PRIME DP - Unbound Medicine ER -