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Cases of melioidosis in a university teaching hospital in Malaysia.
J Microbiol Immunol Infect. 2008 Apr; 41(2):174-9.JM

Abstract

BACKGROUND AND PURPOSE

Melioidosis is an infectious disease caused by Burkholderia pseudomallei that is endemic in Southeast Asia and northern Australia and has also been reported from non-endemic areas of the world. Little is known about the antimicrobial susceptibility pattern and the demography of melioidosis patients in Malaysia.

METHODS

This was a retrospective study of 83 patients with culture-proven B. pseudomallei infections from the University of Malaya Medical Centre, Kuala Lumpur, Malaysia from May 1995 to June 2005. Antimicrobial susceptibility of B. pseudomallei, age, gender and race of patients, nature of specimen, serological evidence and monthly distribution of cases were evaluated.

RESULTS

All isolates were susceptible to piperacillin and piperacillin-tazobactam. The majority of strains were susceptible to imipenem (99%), ceftazidime (94%), amoxicillin-clavulanic acid (95%), ampicillin-sulbactam (94%), tetracycline (89%), chloramphenicol (94%), trimethoprim-sulfamethoxazole (70%), meropenem (88%) and ciprofloxacin (79%). Significant antimicrobial resistance was noted in aminoglycosides and ampicillin. The male-to-female ratio was 3.15:1, and mean age was 43.85 years. The majority of the patients were middle-aged (41-60 years). Malays and Indians made up 39% and 33% of affected patients, while Chinese and others comprised 25% and 3%, respectively. Of 83 patients, 67 were diagnosed by positive blood cultures, and 16 patients were non-bacteremic cases. There were 22 patients in whom B. pseudomallei grew in more than one clinical specimen, and there were 6 polymicrobial cases.

CONCLUSION

Melioidosis is expanding in endemicity around the world. Control of the disease requires close monitoring, improved clinical laboratory standards and aggressive therapy.

Authors+Show Affiliations

Department of Medical Microbiology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia. khinger10@yahoo.com.sg

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18473106

Citation

Raja, Nadeem Sajjad. "Cases of Melioidosis in a University Teaching Hospital in Malaysia." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 41, no. 2, 2008, pp. 174-9.
Raja NS. Cases of melioidosis in a university teaching hospital in Malaysia. J Microbiol Immunol Infect. 2008;41(2):174-9.
Raja, N. S. (2008). Cases of melioidosis in a university teaching hospital in Malaysia. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 41(2), 174-9.
Raja NS. Cases of Melioidosis in a University Teaching Hospital in Malaysia. J Microbiol Immunol Infect. 2008;41(2):174-9. PubMed PMID: 18473106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cases of melioidosis in a university teaching hospital in Malaysia. A1 - Raja,Nadeem Sajjad, PY - 2008/5/14/pubmed PY - 2008/11/5/medline PY - 2008/5/14/entrez SP - 174 EP - 9 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 41 IS - 2 N2 - BACKGROUND AND PURPOSE: Melioidosis is an infectious disease caused by Burkholderia pseudomallei that is endemic in Southeast Asia and northern Australia and has also been reported from non-endemic areas of the world. Little is known about the antimicrobial susceptibility pattern and the demography of melioidosis patients in Malaysia. METHODS: This was a retrospective study of 83 patients with culture-proven B. pseudomallei infections from the University of Malaya Medical Centre, Kuala Lumpur, Malaysia from May 1995 to June 2005. Antimicrobial susceptibility of B. pseudomallei, age, gender and race of patients, nature of specimen, serological evidence and monthly distribution of cases were evaluated. RESULTS: All isolates were susceptible to piperacillin and piperacillin-tazobactam. The majority of strains were susceptible to imipenem (99%), ceftazidime (94%), amoxicillin-clavulanic acid (95%), ampicillin-sulbactam (94%), tetracycline (89%), chloramphenicol (94%), trimethoprim-sulfamethoxazole (70%), meropenem (88%) and ciprofloxacin (79%). Significant antimicrobial resistance was noted in aminoglycosides and ampicillin. The male-to-female ratio was 3.15:1, and mean age was 43.85 years. The majority of the patients were middle-aged (41-60 years). Malays and Indians made up 39% and 33% of affected patients, while Chinese and others comprised 25% and 3%, respectively. Of 83 patients, 67 were diagnosed by positive blood cultures, and 16 patients were non-bacteremic cases. There were 22 patients in whom B. pseudomallei grew in more than one clinical specimen, and there were 6 polymicrobial cases. CONCLUSION: Melioidosis is expanding in endemicity around the world. Control of the disease requires close monitoring, improved clinical laboratory standards and aggressive therapy. SN - 1684-1182 UR - https://www.unboundmedicine.com/medline/citation/18473106/Cases_of_melioidosis_in_a_university_teaching_hospital_in_Malaysia_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -