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Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain.
Neurochem Res. 2008 Oct; 33(10):2134-41.NR

Abstract

The current study investigated the roles of various subtypes of opioid receptors expressed in the thalamic nucleus submedius (Sm) in inhibition of mirror-image allodynia induced by L5/L6 spinal nerve ligation in rats. Morphine was microinjected into the Sm, which produced a dose-dependent inhibition of mirror-image allodynia; this effect was antagonized by pretreatment with non-selective opioid receptor antagonist naloxone. Microinjections of endomorphin-1 (mu-receptor agonist), or [D-Ala(2), D-Leu(5)]-enkephalin (DADLE, delta-/mu-receptor agonist), also inhibited mirror-image allodynia, and these effects were blocked by the selective mu-receptor antagonist, beta-funaltrexamine hydrochloride. The DADLE-induced inhibition, however, was not influenced by the delta-receptor antagonist naltrindole. The kappa-receptor agonist, spiradoline mesylate salt, failed to alter the mirror-image allodynia. These results suggest that Sm opioid receptor signaling is involved in inhibition of mirror-image allodynia; this effect is mediated by mu- (but not delta- and kappa-) opioid receptors in the rat model of neuropathic pain.

Authors+Show Affiliations

Department of Immunology and Pathogenic Biology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18473169

Citation

Wang, Jun-Yang, et al. "Mu-opioid Receptor in the Nucleus Submedius: Involvement in Opioid-induced Inhibition of Mirror-image Allodynia in a Rat Model of Neuropathic Pain." Neurochemical Research, vol. 33, no. 10, 2008, pp. 2134-41.
Wang JY, Zhao M, Huang FS, et al. Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain. Neurochem Res. 2008;33(10):2134-41.
Wang, J. Y., Zhao, M., Huang, F. S., Tang, J. S., & Yuan, Y. K. (2008). Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain. Neurochemical Research, 33(10), 2134-41. https://doi.org/10.1007/s11064-008-9733-6
Wang JY, et al. Mu-opioid Receptor in the Nucleus Submedius: Involvement in Opioid-induced Inhibition of Mirror-image Allodynia in a Rat Model of Neuropathic Pain. Neurochem Res. 2008;33(10):2134-41. PubMed PMID: 18473169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain. AU - Wang,Jun-Yang, AU - Zhao,Mei, AU - Huang,Fen-Sheng, AU - Tang,Jing-Shi, AU - Yuan,Yu-Kang, Y1 - 2008/05/13/ PY - 2007/09/11/received PY - 2008/04/29/accepted PY - 2008/5/14/pubmed PY - 2008/12/17/medline PY - 2008/5/14/entrez SP - 2134 EP - 41 JF - Neurochemical research JO - Neurochem Res VL - 33 IS - 10 N2 - The current study investigated the roles of various subtypes of opioid receptors expressed in the thalamic nucleus submedius (Sm) in inhibition of mirror-image allodynia induced by L5/L6 spinal nerve ligation in rats. Morphine was microinjected into the Sm, which produced a dose-dependent inhibition of mirror-image allodynia; this effect was antagonized by pretreatment with non-selective opioid receptor antagonist naloxone. Microinjections of endomorphin-1 (mu-receptor agonist), or [D-Ala(2), D-Leu(5)]-enkephalin (DADLE, delta-/mu-receptor agonist), also inhibited mirror-image allodynia, and these effects were blocked by the selective mu-receptor antagonist, beta-funaltrexamine hydrochloride. The DADLE-induced inhibition, however, was not influenced by the delta-receptor antagonist naltrindole. The kappa-receptor agonist, spiradoline mesylate salt, failed to alter the mirror-image allodynia. These results suggest that Sm opioid receptor signaling is involved in inhibition of mirror-image allodynia; this effect is mediated by mu- (but not delta- and kappa-) opioid receptors in the rat model of neuropathic pain. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/18473169/Mu_opioid_receptor_in_the_nucleus_submedius:_involvement_in_opioid_induced_inhibition_of_mirror_image_allodynia_in_a_rat_model_of_neuropathic_pain_ L2 - https://doi.org/10.1007/s11064-008-9733-6 DB - PRIME DP - Unbound Medicine ER -