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Advanced glycation end products and cardiovascular disease.
Curr Diabetes Rev 2008; 4(2):92-100CD

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Advanced glycation end products [AGEs] seem to play an important role for the development and/or progression of CVD mainly through induction of oxidative stress and inflammation. AGEs are a heterogenous group of molecules formed by the nonenzymatic reaction of reducing sugars with amino acids of proteins, lipids and nucleic acids. Recent studies suggest that in addition to those endogenously formed, diet constitutes an important exogenous source of AGEs. Diet-derived AGEs contribute to the whole body AGE pool and the AGE-related pathology. Recent in vitro and in vivo studies revealed significant correlations between diet-derived AGEs and several risk factors and/or markers of CVD, suggesting the dietary AGEs restriction as a promising therapeutic intervention.

Authors+Show Affiliations

Endocrine Unit, 2nd Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Attikon University Hospital, Athens, Greece. moly6592@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18473756

Citation

Peppa, Melpomeni, and Sotirios A. Raptis. "Advanced Glycation End Products and Cardiovascular Disease." Current Diabetes Reviews, vol. 4, no. 2, 2008, pp. 92-100.
Peppa M, Raptis SA. Advanced glycation end products and cardiovascular disease. Curr Diabetes Rev. 2008;4(2):92-100.
Peppa, M., & Raptis, S. A. (2008). Advanced glycation end products and cardiovascular disease. Current Diabetes Reviews, 4(2), pp. 92-100.
Peppa M, Raptis SA. Advanced Glycation End Products and Cardiovascular Disease. Curr Diabetes Rev. 2008;4(2):92-100. PubMed PMID: 18473756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advanced glycation end products and cardiovascular disease. AU - Peppa,Melpomeni, AU - Raptis,Sotirios A, PY - 2008/5/14/pubmed PY - 2009/2/14/medline PY - 2008/5/14/entrez SP - 92 EP - 100 JF - Current diabetes reviews JO - Curr Diabetes Rev VL - 4 IS - 2 N2 - Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Advanced glycation end products [AGEs] seem to play an important role for the development and/or progression of CVD mainly through induction of oxidative stress and inflammation. AGEs are a heterogenous group of molecules formed by the nonenzymatic reaction of reducing sugars with amino acids of proteins, lipids and nucleic acids. Recent studies suggest that in addition to those endogenously formed, diet constitutes an important exogenous source of AGEs. Diet-derived AGEs contribute to the whole body AGE pool and the AGE-related pathology. Recent in vitro and in vivo studies revealed significant correlations between diet-derived AGEs and several risk factors and/or markers of CVD, suggesting the dietary AGEs restriction as a promising therapeutic intervention. SN - 1875-6417 UR - https://www.unboundmedicine.com/medline/citation/18473756/Advanced_glycation_end_products_and_cardiovascular_disease_ L2 - http://www.eurekaselect.com/66826/article DB - PRIME DP - Unbound Medicine ER -