Tags

Type your tag names separated by a space and hit enter

Improvement of the dermal epidermal junction in human reconstructed skin by a new c-xylopyranoside derivative.
Eur J Dermatol. 2008 May-Jun; 18(3):297-302.EJ

Abstract

Skin aging entails drastic changes in the extracellular dermal matrix (ECM) and dermal-epidermal junction (DEJ). These biological alterations are reflected in the clinical signs of aged skin. A new C-xylopyranoside derivative, C-beta-D-xylopyranoside-2-hydroxy-propane (C-Xyloside) has been shown to induce neo-synthesis of matrix proteins such as glycosaminoglycans and heparan sulfate proteoglycans. The aim of this study was to assess the effects of C-Xyloside on markers of the dermal epidermal junction. Basement membrane components, collagen IV, collagen VII and laminin 5 as well as sub-epidermal dermal markers, pro-collagen I and fibrillin 1 were analysed using immunohistochemistry in a reconstructed skin model, including a dermal equivalent populated with living fibroblasts. Levels of mRNA of collagen VII alpha1 and collagen IV alpha1 were evaluated in dermal fibroblasts using RT-PCR. The results showed that C-Xyloside significantly induced a higher deposition of basement membrane and DEJ proteins in the reconstructed skin model and increased collagen VII gene expression. These findings indicate that, in addition to stimulating glycosaminoglycan and heparan sulfate proteoglycan expression, C-Xyloside improves the morphogenesis of the whole DEJ, and strongly suggests beneficial effects in aged skin from restoring DEJ integrity.

Authors+Show Affiliations

L'Oréal Recherche, Centre de Recherche C Zviak, 90 rue du Général Roguet, 92583 Clichy Cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18474459

Citation

Sok, Juliette, et al. "Improvement of the Dermal Epidermal Junction in Human Reconstructed Skin By a New C-xylopyranoside Derivative." European Journal of Dermatology : EJD, vol. 18, no. 3, 2008, pp. 297-302.
Sok J, Pineau N, Dalko-Csiba M, et al. Improvement of the dermal epidermal junction in human reconstructed skin by a new c-xylopyranoside derivative. Eur J Dermatol. 2008;18(3):297-302.
Sok, J., Pineau, N., Dalko-Csiba, M., Breton, L., & Bernerd, F. (2008). Improvement of the dermal epidermal junction in human reconstructed skin by a new c-xylopyranoside derivative. European Journal of Dermatology : EJD, 18(3), 297-302. https://doi.org/10.1684/ejd.2008.0392
Sok J, et al. Improvement of the Dermal Epidermal Junction in Human Reconstructed Skin By a New C-xylopyranoside Derivative. Eur J Dermatol. 2008 May-Jun;18(3):297-302. PubMed PMID: 18474459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of the dermal epidermal junction in human reconstructed skin by a new c-xylopyranoside derivative. AU - Sok,Juliette, AU - Pineau,Nathalie, AU - Dalko-Csiba,Maria, AU - Breton,Lionel, AU - Bernerd,Françoise, Y1 - 2008/05/13/ PY - 2008/01/15/accepted PY - 2008/5/14/pubmed PY - 2008/10/1/medline PY - 2008/5/14/entrez SP - 297 EP - 302 JF - European journal of dermatology : EJD JO - Eur J Dermatol VL - 18 IS - 3 N2 - Skin aging entails drastic changes in the extracellular dermal matrix (ECM) and dermal-epidermal junction (DEJ). These biological alterations are reflected in the clinical signs of aged skin. A new C-xylopyranoside derivative, C-beta-D-xylopyranoside-2-hydroxy-propane (C-Xyloside) has been shown to induce neo-synthesis of matrix proteins such as glycosaminoglycans and heparan sulfate proteoglycans. The aim of this study was to assess the effects of C-Xyloside on markers of the dermal epidermal junction. Basement membrane components, collagen IV, collagen VII and laminin 5 as well as sub-epidermal dermal markers, pro-collagen I and fibrillin 1 were analysed using immunohistochemistry in a reconstructed skin model, including a dermal equivalent populated with living fibroblasts. Levels of mRNA of collagen VII alpha1 and collagen IV alpha1 were evaluated in dermal fibroblasts using RT-PCR. The results showed that C-Xyloside significantly induced a higher deposition of basement membrane and DEJ proteins in the reconstructed skin model and increased collagen VII gene expression. These findings indicate that, in addition to stimulating glycosaminoglycan and heparan sulfate proteoglycan expression, C-Xyloside improves the morphogenesis of the whole DEJ, and strongly suggests beneficial effects in aged skin from restoring DEJ integrity. SN - 1167-1122 UR - https://www.unboundmedicine.com/medline/citation/18474459/Improvement_of_the_dermal_epidermal_junction_in_human_reconstructed_skin_by_a_new_c_xylopyranoside_derivative_ L2 - https://antibodies.cancer.gov/detail/CPTC-CD44-1 DB - PRIME DP - Unbound Medicine ER -