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Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus.
J Gen Virol 2008; 89(Pt 6):1364-70JG

Abstract

Transcripts for the Epstein-Barr virus (EBV)-encoded nuclear antigens are initiated at the alternative promoters Wp, Cp and Qp. Although the host cell-dependent activity of Cp is regulated by DNA methylation, Qp is unmethylated independently of its activity. Because histone modifications affect the chromatin structure, we compared the levels of diacetylated histone H3, tetraacetylated histone H4 and histone H3 dimethylated on lysine 4 (H3K4me2) at Cp and Qp, in well characterized cell lines representing the major EBV latency types. We found an activity-dependent histone code: acetylated histones marked active Cp, whereas active Qp was selectively enriched both in acetylated histones and H3K4me2. We concluded that active (but not silent) Cp and Qp are located to 'acetylation islands' in latent, episomal EBV genomes, similar to the active chromatin domains of the human genome.

Authors+Show Affiliations

Microbiological Research Group, National Center for Epidemiology, Pihenö u. 1, H-1529 Budapest, Hungary. fejer@immunbio.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18474551

Citation

Fejer, György, et al. "Latency Type-specific Distribution of Epigenetic Marks at the Alternative Promoters Cp and Qp of Epstein-Barr Virus." The Journal of General Virology, vol. 89, no. Pt 6, 2008, pp. 1364-70.
Fejer G, Koroknai A, Banati F, et al. Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus. J Gen Virol. 2008;89(Pt 6):1364-70.
Fejer, G., Koroknai, A., Banati, F., Györy, I., Salamon, D., Wolf, H., ... Minarovits, J. (2008). Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus. The Journal of General Virology, 89(Pt 6), pp. 1364-70. doi:10.1099/vir.0.83594-0.
Fejer G, et al. Latency Type-specific Distribution of Epigenetic Marks at the Alternative Promoters Cp and Qp of Epstein-Barr Virus. J Gen Virol. 2008;89(Pt 6):1364-70. PubMed PMID: 18474551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus. AU - Fejer,György, AU - Koroknai,Anita, AU - Banati,Ferenc, AU - Györy,Ildiko, AU - Salamon,Daniel, AU - Wolf,Hans, AU - Niller,Hans Helmut, AU - Minarovits,Janos, PY - 2008/5/14/pubmed PY - 2008/7/2/medline PY - 2008/5/14/entrez SP - 1364 EP - 70 JF - The Journal of general virology JO - J. Gen. Virol. VL - 89 IS - Pt 6 N2 - Transcripts for the Epstein-Barr virus (EBV)-encoded nuclear antigens are initiated at the alternative promoters Wp, Cp and Qp. Although the host cell-dependent activity of Cp is regulated by DNA methylation, Qp is unmethylated independently of its activity. Because histone modifications affect the chromatin structure, we compared the levels of diacetylated histone H3, tetraacetylated histone H4 and histone H3 dimethylated on lysine 4 (H3K4me2) at Cp and Qp, in well characterized cell lines representing the major EBV latency types. We found an activity-dependent histone code: acetylated histones marked active Cp, whereas active Qp was selectively enriched both in acetylated histones and H3K4me2. We concluded that active (but not silent) Cp and Qp are located to 'acetylation islands' in latent, episomal EBV genomes, similar to the active chromatin domains of the human genome. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/18474551/Latency_type_specific_distribution_of_epigenetic_marks_at_the_alternative_promoters_Cp_and_Qp_of_Epstein_Barr_virus_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/vir.0.83594-0 DB - PRIME DP - Unbound Medicine ER -