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Bronchiolitis obliterans in children.
Curr Opin Pediatr 2008; 20(3):272-8CO

Abstract

PURPOSE OF REVIEW

In this review, we discuss recent advances in our understanding of the etiology, pathology and pathogenesis, clinical presentation, diagnosis, treatment, and outcome of bronchiolitis obliterans in the nontransplant, pediatric population.

RECENT FINDINGS

The diagnosis of bronchiolitis obliterans in children can be made with confidence based on clinical presentation, particularly with a history of adenovirus bronchiolitis or pneumonia, fixed obstructive lung disease on pulmonary function testing, and characteristic changes of mosaic perfusion, vascular attenuation, and central bronchiectasis on chest high-resolution computed tomography, thus avoiding the need for lung biopsy in most patients. Patients with postinfectious bronchiolitis obliterans generally have chronic, nonprogressive disease; in contrast, patients with bronchiolitis obliterans from Stevens-Johnson syndrome often have progressive disease that may require lung transplantation.

SUMMARY

Bronchiolitis obliterans is a rare form of chronic obstructive lung disease that follows a severe insult to the lower respiratory tract, resulting in fibrosis of the small airways. In the nontransplant pediatric population, adenovirus infection is the most common cause. Treatment is largely supportive and prognosis is mainly related to the underlying cause and to the severity of the initial insult.

Authors+Show Affiliations

Pediatric Pulmonary Section, Department of Pediatrics, Texas Children's Hospital, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18475095

Citation

Moonnumakal, Siby P., and Leland L. Fan. "Bronchiolitis Obliterans in Children." Current Opinion in Pediatrics, vol. 20, no. 3, 2008, pp. 272-8.
Moonnumakal SP, Fan LL. Bronchiolitis obliterans in children. Curr Opin Pediatr. 2008;20(3):272-8.
Moonnumakal, S. P., & Fan, L. L. (2008). Bronchiolitis obliterans in children. Current Opinion in Pediatrics, 20(3), pp. 272-8. doi:10.1097/MOP.0b013e3282ff62e9.
Moonnumakal SP, Fan LL. Bronchiolitis Obliterans in Children. Curr Opin Pediatr. 2008;20(3):272-8. PubMed PMID: 18475095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchiolitis obliterans in children. AU - Moonnumakal,Siby P, AU - Fan,Leland L, PY - 2008/5/14/pubmed PY - 2008/8/2/medline PY - 2008/5/14/entrez SP - 272 EP - 8 JF - Current opinion in pediatrics JO - Curr. Opin. Pediatr. VL - 20 IS - 3 N2 - PURPOSE OF REVIEW: In this review, we discuss recent advances in our understanding of the etiology, pathology and pathogenesis, clinical presentation, diagnosis, treatment, and outcome of bronchiolitis obliterans in the nontransplant, pediatric population. RECENT FINDINGS: The diagnosis of bronchiolitis obliterans in children can be made with confidence based on clinical presentation, particularly with a history of adenovirus bronchiolitis or pneumonia, fixed obstructive lung disease on pulmonary function testing, and characteristic changes of mosaic perfusion, vascular attenuation, and central bronchiectasis on chest high-resolution computed tomography, thus avoiding the need for lung biopsy in most patients. Patients with postinfectious bronchiolitis obliterans generally have chronic, nonprogressive disease; in contrast, patients with bronchiolitis obliterans from Stevens-Johnson syndrome often have progressive disease that may require lung transplantation. SUMMARY: Bronchiolitis obliterans is a rare form of chronic obstructive lung disease that follows a severe insult to the lower respiratory tract, resulting in fibrosis of the small airways. In the nontransplant pediatric population, adenovirus infection is the most common cause. Treatment is largely supportive and prognosis is mainly related to the underlying cause and to the severity of the initial insult. SN - 1531-698X UR - https://www.unboundmedicine.com/medline/citation/18475095/Bronchiolitis_obliterans_in_children_ L2 - http://Insights.ovid.com/pubmed?pmid=18475095 DB - PRIME DP - Unbound Medicine ER -