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[The relationship of paroxysmal atrial fibrillation and regional sympathetic innervations in the atria and pulmonary veins: experiment with dogs].
Zhonghua Yi Xue Za Zhi. 2007 Dec 25; 87(48):3433-5.ZY

Abstract

OBJECTIVE

To test the hypothesis that regional sympathetic innervation in the atria and pulmonary veins are correlated with atrial fibrillation (AF).

METHODS

Sixteen adult mongrel dogs underwent thoracotomy under general anesthesia. Bilateral cervical vagal trunks were decentralized. Multipolar catheters were placed into right atrial appendage (RAA), left atrial appendage (LAA), left atrium (LA), left superior pulmonary vein (LSPV), left inferior pulmonary vein (LIPV), right superior pulmonary vein (RSPV), and left inferior pulmonary vein (LIPV). The bilateral sympathovagal trunks were stimulated, S1S1 burst stimulation and S1S2 stimulation procedure were performed on different points of RAA, LAA, LA, LSPV, LIPV, RSPV, and LIPV. The TF thus induced was monitored. After that, the dogs were killed with their hearts and lungs were taken out. Immunocytochemical staining of cardiac nerves was performed using anti-tyrosine hydroxylase (TH) antibodies. The nerve fiber density was counted manually for each case and expressed as the mean number per slice.

RESULTS

Two dogs died during the experiment and the whole procedure was completed on 14 dogs. There was no significant difference in the AF induction rate among the most points, however, the AF induction rate of the RIPV was significantly lower than those of the other points (all P < 0.05). The levels of density of TH-positive nerves in the atria and atrial appendages were significantly higher than those in the pulmonary veins (P = 0.02). The density of TH-positive nerves in the dogs with AF was significantly higher than that in the dog without AF (P < 0.05). The innervation of sympathetic nerves in atria and pulmonary veins was highly correlated to the induction of atrial fibrillation (r = 0.83).

CONCLUSION

Regional sympathetic hyperinnervation plays an important role in atrial fibrillation induction.

Links

Publisher Full Text

Authors+Show Affiliations

Yi Z
Department of Cardiology, People's Hospital, Peking University, Beijing 100044, China.
Zhang HC
No affiliation info available
Zhang P
No affiliation info available
Liu G
No affiliation info available
Lu P
No affiliation info available
Sun JL
No affiliation info available
Liu B
No affiliation info available
Guo JH
No affiliation info available

MeSH

AnimalsAtrial FibrillationDogsElectric StimulationHeartHeart AtriaImmunohistochemistryMaleNerve FibersPulmonary VeinsSympathetic Nervous SystemThoracotomyTyrosine 3-Monooxygenase

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18476546

Citation

Yi, Zhong, et al. "[The Relationship of Paroxysmal Atrial Fibrillation and Regional Sympathetic Innervations in the Atria and Pulmonary Veins: Experiment With Dogs]." Zhonghua Yi Xue Za Zhi, vol. 87, no. 48, 2007, pp. 3433-5.
Yi Z, Zhang HC, Zhang P, et al. [The relationship of paroxysmal atrial fibrillation and regional sympathetic innervations in the atria and pulmonary veins: experiment with dogs]. Zhonghua Yi Xue Za Zhi. 2007;87(48):3433-5.
Yi, Z., Zhang, H. C., Zhang, P., Liu, G., Lu, P., Sun, J. L., Liu, B., & Guo, J. H. (2007). [The relationship of paroxysmal atrial fibrillation and regional sympathetic innervations in the atria and pulmonary veins: experiment with dogs]. Zhonghua Yi Xue Za Zhi, 87(48), 3433-5.
Yi Z, et al. [The Relationship of Paroxysmal Atrial Fibrillation and Regional Sympathetic Innervations in the Atria and Pulmonary Veins: Experiment With Dogs]. Zhonghua Yi Xue Za Zhi. 2007 Dec 25;87(48):3433-5. PubMed PMID: 18476546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The relationship of paroxysmal atrial fibrillation and regional sympathetic innervations in the atria and pulmonary veins: experiment with dogs]. AU - Yi,Zhong, AU - Zhang,Hai-cheng, AU - Zhang,Ping, AU - Liu,Gang, AU - Lu,Peng, AU - Sun,Jian-ling, AU - Liu,Bin, AU - Guo,Ji-hong, PY - 2008/5/15/pubmed PY - 2008/8/30/medline PY - 2008/5/15/entrez SP - 3433 EP - 5 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 87 IS - 48 N2 - OBJECTIVE: To test the hypothesis that regional sympathetic innervation in the atria and pulmonary veins are correlated with atrial fibrillation (AF). METHODS: Sixteen adult mongrel dogs underwent thoracotomy under general anesthesia. Bilateral cervical vagal trunks were decentralized. Multipolar catheters were placed into right atrial appendage (RAA), left atrial appendage (LAA), left atrium (LA), left superior pulmonary vein (LSPV), left inferior pulmonary vein (LIPV), right superior pulmonary vein (RSPV), and left inferior pulmonary vein (LIPV). The bilateral sympathovagal trunks were stimulated, S1S1 burst stimulation and S1S2 stimulation procedure were performed on different points of RAA, LAA, LA, LSPV, LIPV, RSPV, and LIPV. The TF thus induced was monitored. After that, the dogs were killed with their hearts and lungs were taken out. Immunocytochemical staining of cardiac nerves was performed using anti-tyrosine hydroxylase (TH) antibodies. The nerve fiber density was counted manually for each case and expressed as the mean number per slice. RESULTS: Two dogs died during the experiment and the whole procedure was completed on 14 dogs. There was no significant difference in the AF induction rate among the most points, however, the AF induction rate of the RIPV was significantly lower than those of the other points (all P < 0.05). The levels of density of TH-positive nerves in the atria and atrial appendages were significantly higher than those in the pulmonary veins (P = 0.02). The density of TH-positive nerves in the dogs with AF was significantly higher than that in the dog without AF (P < 0.05). The innervation of sympathetic nerves in atria and pulmonary veins was highly correlated to the induction of atrial fibrillation (r = 0.83). CONCLUSION: Regional sympathetic hyperinnervation plays an important role in atrial fibrillation induction. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/18476546/[The_relationship_of_paroxysmal_atrial_fibrillation_and_regional_sympathetic_innervations_in_the_atria_and_pulmonary_veins:_experiment_with_dogs]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2007&amp;vol=87&amp;issue=48&amp;fpage=3433 DB - PRIME DP - Unbound Medicine ER -