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Serum 25-hydroxyvitamin D in erythropoietic protoporphyria.
Br J Dermatol. 2008 Jul; 159(1):211-3.BJ

Abstract

BACKGROUND

Vitamin D, produced by the action of sunlight on skin, is an important hormone for calcium homeostasis and has been implicated as tumour-protective agent. Some previous studies of photosensitive patients who actively avoid sunlight have failed to show convincing evidence of vitamin D insufficiency.

OBJECTIVES

The aim of this study was to characterize the vitamin D status of a large cohort of patients with erythropoietic protoporphyria (EPP).

METHODS

U.K. patients with EPP were recruited prospectively and seen locally by a single study investigator. A blood sample was taken for vitamin D assay. All blood analyses were performed in the same laboratory.

RESULTS

A cohort of 201 patients with known EPP was seen over a 7-month period between January and July. Thirty-four patients (17%) were deficient in vitamin D and 126 (63%) had insufficient vitamin D. Both insufficiency and deficiency were significantly associated with the total erythrocyte protoporphyrin concentration and inversely with the time in minutes to the onset of symptoms following sunlight exposure.

CONCLUSIONS

This is the first report of significant levels of vitamin D deficiency and insufficiency in a large cohort of patients with a photodermatosis. Such individuals are at risk of associated adverse events. In future, clinicians should consider monitoring 25-hydroxyvitamin D levels and instigating oral supplementation or dietary advice if appropriate.

Authors+Show Affiliations

Department of Dermatology, Queen Margaret Hospital, Dunfermline, KY12 0SU, UK. alex.holme@faht.scot.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18476956

Citation

Holme, S A., et al. "Serum 25-hydroxyvitamin D in Erythropoietic Protoporphyria." The British Journal of Dermatology, vol. 159, no. 1, 2008, pp. 211-3.
Holme SA, Anstey AV, Badminton MN, et al. Serum 25-hydroxyvitamin D in erythropoietic protoporphyria. Br J Dermatol. 2008;159(1):211-3.
Holme, S. A., Anstey, A. V., Badminton, M. N., & Elder, G. H. (2008). Serum 25-hydroxyvitamin D in erythropoietic protoporphyria. The British Journal of Dermatology, 159(1), 211-3. https://doi.org/10.1111/j.1365-2133.2008.08616.x
Holme SA, et al. Serum 25-hydroxyvitamin D in Erythropoietic Protoporphyria. Br J Dermatol. 2008;159(1):211-3. PubMed PMID: 18476956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D in erythropoietic protoporphyria. AU - Holme,S A, AU - Anstey,A V, AU - Badminton,M N, AU - Elder,G H, Y1 - 2008/07/01/ PY - 2008/5/15/pubmed PY - 2008/10/24/medline PY - 2008/5/15/entrez SP - 211 EP - 3 JF - The British journal of dermatology JO - Br J Dermatol VL - 159 IS - 1 N2 - BACKGROUND: Vitamin D, produced by the action of sunlight on skin, is an important hormone for calcium homeostasis and has been implicated as tumour-protective agent. Some previous studies of photosensitive patients who actively avoid sunlight have failed to show convincing evidence of vitamin D insufficiency. OBJECTIVES: The aim of this study was to characterize the vitamin D status of a large cohort of patients with erythropoietic protoporphyria (EPP). METHODS: U.K. patients with EPP were recruited prospectively and seen locally by a single study investigator. A blood sample was taken for vitamin D assay. All blood analyses were performed in the same laboratory. RESULTS: A cohort of 201 patients with known EPP was seen over a 7-month period between January and July. Thirty-four patients (17%) were deficient in vitamin D and 126 (63%) had insufficient vitamin D. Both insufficiency and deficiency were significantly associated with the total erythrocyte protoporphyrin concentration and inversely with the time in minutes to the onset of symptoms following sunlight exposure. CONCLUSIONS: This is the first report of significant levels of vitamin D deficiency and insufficiency in a large cohort of patients with a photodermatosis. Such individuals are at risk of associated adverse events. In future, clinicians should consider monitoring 25-hydroxyvitamin D levels and instigating oral supplementation or dietary advice if appropriate. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/18476956/Serum_25_hydroxyvitamin_D_in_erythropoietic_protoporphyria_ L2 - https://doi.org/10.1111/j.1365-2133.2008.08616.x DB - PRIME DP - Unbound Medicine ER -