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Plasma levels of natriuretic peptide type B and A in children with heart disease with different types of cardiac load or systolic dysfunction.
Clin Physiol Funct Imaging. 2008 Jul; 28(4):277-84.CP

Abstract

Natriuretic peptide levels B (BNP) and A (ANP) have been described in children with different diagnose of congenital heart defects (CHD). However, the impact of the type of cardiac load per se on natriuretic peptide levels, irrespective of diagnosis, has not been reported. The aim of the present study was to evaluate the levels of BNP and ANP in children with congenital and acquired heart disease according to different types of cardiac load. Plasma BNP and ANP were analysed in 137 children with CHD/heart disease, median age 2.9 (0.3-16.7) years. Haemodynamic load was classified as: no overload, pressure overload, volume overload of right and/or left ventricle and systolic ventricular dysfunction. Twenty-three children without heart disease served as controls for the natriuretic peptide measurements. The highest BNP and ANP values were observed in the systolic dysfunction, 613 ng l(-1) (81.8-3910) and 431 (43.8-1990), and volume groups, 29.8 (5.5-352) and 93.0 (15.9-346), respectively, whereas the values in the pressure, 17.9 (0.7-315) and 51.9 (8.7-210), and no overload groups, 10.3 (0.2-28.1) and 28.6 (8.6-105), respectively, were only slightly higher than those in the controls 4.7 (0.0-17.7) and 32.9 (11.7-212.2), respectively. The highest BNP and ANP values were seen in children with systolic dysfunction, while volume overload in the absence of heart failure resulted in higher levels than pressure overload.

Authors+Show Affiliations

The Department of Cardiothoracic Surgery, Shalgrenska University Hospital, Göteborg, Sweden. andreas.westerlind@vgregion.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18476995

Citation

Westerlind, Andreas, et al. "Plasma Levels of Natriuretic Peptide Type B and a in Children With Heart Disease With Different Types of Cardiac Load or Systolic Dysfunction." Clinical Physiology and Functional Imaging, vol. 28, no. 4, 2008, pp. 277-84.
Westerlind A, Wåhlander H, Berggren H, et al. Plasma levels of natriuretic peptide type B and A in children with heart disease with different types of cardiac load or systolic dysfunction. Clin Physiol Funct Imaging. 2008;28(4):277-84.
Westerlind, A., Wåhlander, H., Berggren, H., Lundberg, P. A., & Holmgren, D. (2008). Plasma levels of natriuretic peptide type B and A in children with heart disease with different types of cardiac load or systolic dysfunction. Clinical Physiology and Functional Imaging, 28(4), 277-84. https://doi.org/10.1111/j.1475-097X.2008.00805.x
Westerlind A, et al. Plasma Levels of Natriuretic Peptide Type B and a in Children With Heart Disease With Different Types of Cardiac Load or Systolic Dysfunction. Clin Physiol Funct Imaging. 2008;28(4):277-84. PubMed PMID: 18476995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma levels of natriuretic peptide type B and A in children with heart disease with different types of cardiac load or systolic dysfunction. AU - Westerlind,Andreas, AU - Wåhlander,Håkan, AU - Berggren,Håkan, AU - Lundberg,Per-Arne, AU - Holmgren,Daniel, Y1 - 2008/07/01/ PY - 2008/5/15/pubmed PY - 2008/11/5/medline PY - 2008/5/15/entrez SP - 277 EP - 84 JF - Clinical physiology and functional imaging JO - Clin Physiol Funct Imaging VL - 28 IS - 4 N2 - Natriuretic peptide levels B (BNP) and A (ANP) have been described in children with different diagnose of congenital heart defects (CHD). However, the impact of the type of cardiac load per se on natriuretic peptide levels, irrespective of diagnosis, has not been reported. The aim of the present study was to evaluate the levels of BNP and ANP in children with congenital and acquired heart disease according to different types of cardiac load. Plasma BNP and ANP were analysed in 137 children with CHD/heart disease, median age 2.9 (0.3-16.7) years. Haemodynamic load was classified as: no overload, pressure overload, volume overload of right and/or left ventricle and systolic ventricular dysfunction. Twenty-three children without heart disease served as controls for the natriuretic peptide measurements. The highest BNP and ANP values were observed in the systolic dysfunction, 613 ng l(-1) (81.8-3910) and 431 (43.8-1990), and volume groups, 29.8 (5.5-352) and 93.0 (15.9-346), respectively, whereas the values in the pressure, 17.9 (0.7-315) and 51.9 (8.7-210), and no overload groups, 10.3 (0.2-28.1) and 28.6 (8.6-105), respectively, were only slightly higher than those in the controls 4.7 (0.0-17.7) and 32.9 (11.7-212.2), respectively. The highest BNP and ANP values were seen in children with systolic dysfunction, while volume overload in the absence of heart failure resulted in higher levels than pressure overload. SN - 1475-0961 UR - https://www.unboundmedicine.com/medline/citation/18476995/Plasma_levels_of_natriuretic_peptide_type_B_and_A_in_children_with_heart_disease_with_different_types_of_cardiac_load_or_systolic_dysfunction_ L2 - https://doi.org/10.1111/j.1475-097X.2008.00805.x DB - PRIME DP - Unbound Medicine ER -