Tags

Type your tag names separated by a space and hit enter

Sulphidopeptide leukotrienes in asthma.

Abstract

Bronchial asthma is characterized by airways inflammation and airways hyperresponsiveness. It is unlikely that the pathophysiology of asthma and bronchial hyperresponsiveness can be explained on the basis of a single cell or a single class of mediators. Nevertheless, the possibility that leukotrienes may contribute to the pathogenesis of the inflammatory, vasoactive ans spasmogenic components of bronchial asthma is suggested by the properties of these lipid mediators, the preferential capacity of inflammatory cells to generate leukotrienes and the presence of leukotrienes in the airways of asthmatic subjects. The sulphidopeptide leukotrienes are potent bronchoconstrictor agonists when inhaled. The airways of asthmatic subjects are hyperresponsive to leukotrienes as to other bronchoconstrictor agonists. Nevertheless, the airways responsiveness of asthmatic subjects to these agonists demonstrate several unusual properties. While the airways of asthmatic subjects are relatively less responsive to LTC4 and LTD4, compared to agents such as histamine or methacholine, they demonstrate a marked and selective hyperresponsiveness to LTE4, suggesting a possibly unique role for this mediator in the pathogenesis of airways hyperresponsiveness. In addition an increased sensitivity of the airways to LTE4 may contribute to the mechanism of aspirin-induced asthma. The capacity of the sulphidopeptide leukotrienes to increase the airways responsiveness of normal subjects to methacholine and of asthmatic subjects to histamine is further evidence for a role for these substances in the pathogenesis of bronchial asthma.

Authors+Show Affiliations

Department of Allergy and Allied Respiratory Disorders, Guy's Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

1847780

Citation

Lee, T H., et al. "Sulphidopeptide Leukotrienes in Asthma." Advances in Prostaglandin, Thromboxane, and Leukotriene Research, vol. 21A, 1991, pp. 415-9.
Lee TH, O'Hickey SP, Jacques C, et al. Sulphidopeptide leukotrienes in asthma. Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:415-9.
Lee, T. H., O'Hickey, S. P., Jacques, C., Hawksworth, R. J., Arm, J. P., Christie, P., Spur, B. W., & Crea, A. E. (1991). Sulphidopeptide leukotrienes in asthma. Advances in Prostaglandin, Thromboxane, and Leukotriene Research, 21A, 415-9.
Lee TH, et al. Sulphidopeptide Leukotrienes in Asthma. Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:415-9. PubMed PMID: 1847780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulphidopeptide leukotrienes in asthma. AU - Lee,T H, AU - O'Hickey,S P, AU - Jacques,C, AU - Hawksworth,R J, AU - Arm,J P, AU - Christie,P, AU - Spur,B W, AU - Crea,A E, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 415 EP - 9 JF - Advances in prostaglandin, thromboxane, and leukotriene research JO - Adv Prostaglandin Thromboxane Leukot Res VL - 21A N2 - Bronchial asthma is characterized by airways inflammation and airways hyperresponsiveness. It is unlikely that the pathophysiology of asthma and bronchial hyperresponsiveness can be explained on the basis of a single cell or a single class of mediators. Nevertheless, the possibility that leukotrienes may contribute to the pathogenesis of the inflammatory, vasoactive ans spasmogenic components of bronchial asthma is suggested by the properties of these lipid mediators, the preferential capacity of inflammatory cells to generate leukotrienes and the presence of leukotrienes in the airways of asthmatic subjects. The sulphidopeptide leukotrienes are potent bronchoconstrictor agonists when inhaled. The airways of asthmatic subjects are hyperresponsive to leukotrienes as to other bronchoconstrictor agonists. Nevertheless, the airways responsiveness of asthmatic subjects to these agonists demonstrate several unusual properties. While the airways of asthmatic subjects are relatively less responsive to LTC4 and LTD4, compared to agents such as histamine or methacholine, they demonstrate a marked and selective hyperresponsiveness to LTE4, suggesting a possibly unique role for this mediator in the pathogenesis of airways hyperresponsiveness. In addition an increased sensitivity of the airways to LTE4 may contribute to the mechanism of aspirin-induced asthma. The capacity of the sulphidopeptide leukotrienes to increase the airways responsiveness of normal subjects to methacholine and of asthmatic subjects to histamine is further evidence for a role for these substances in the pathogenesis of bronchial asthma. SN - 0732-8141 UR - https://www.unboundmedicine.com/medline/citation/1847780/Sulphidopeptide_leukotrienes_in_asthma_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -