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Clinical utility of serum N-terminal pro-B-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity.
J Am Vet Med Assoc. 2008 May 15; 232(10):1496-503.JA

Abstract

OBJECTIVE

To determine whether serum N-terminal pro-B-type natriuretic (NT-proBNP) concentration could be used to identify cardiac disease in dogs and to assess disease severity in affected dogs.

DESIGN

Cross-sectional study.

ANIMALS

119 dogs with mitral valve disease, 18 dogs with dilated cardiomyopathy, and 40 healthy control dogs.

PROCEDURES

Serum NT-proBNP concentration was measured with an ELISA validated for use in dogs. Results of physical examination, thoracic radiography, echocardiography, and serum biochemical analyses were recorded for dogs with cardiac disease.

RESULTS

Serum NT-proBNP concentration was significantly higher in dogs with cardiac disease than in control dogs, and a serum NT-proBNP concentration > 445 pmol/L could be used to discriminate dogs with cardiac disease from control dogs with a sensitivity of 83.2% and specificity of 90.0%. In dogs with cardiac disease, serum NT-proBNP concentration was correlated with heart rate, respiratory rate, echocardiographic heart size, and renal function. For dogs with cardiac disease, serum NT-proBNP concentration could be used to discriminate dogs with and without radiographic evidence of cardiomegaly and dogs with and without congestive heart failure.

CONCLUSIONS AND CLINICAL RELEVANCE

Results suggested that serum NT-proBNP concentration may be a useful adjunct clinical test for diagnosing cardiac disease in dogs and assessing the severity of disease in dogs with cardiac disease.

Authors+Show Affiliations

Department of Veterinary Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18479239

Citation

Oyama, Mark A., et al. "Clinical Utility of Serum N-terminal pro-B-type Natriuretic Peptide Concentration for Identifying Cardiac Disease in Dogs and Assessing Disease Severity." Journal of the American Veterinary Medical Association, vol. 232, no. 10, 2008, pp. 1496-503.
Oyama MA, Fox PR, Rush JE, et al. Clinical utility of serum N-terminal pro-B-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity. J Am Vet Med Assoc. 2008;232(10):1496-503.
Oyama, M. A., Fox, P. R., Rush, J. E., Rozanski, E. A., & Lesser, M. (2008). Clinical utility of serum N-terminal pro-B-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity. Journal of the American Veterinary Medical Association, 232(10), 1496-503. https://doi.org/10.2460/javma.232.10.1496
Oyama MA, et al. Clinical Utility of Serum N-terminal pro-B-type Natriuretic Peptide Concentration for Identifying Cardiac Disease in Dogs and Assessing Disease Severity. J Am Vet Med Assoc. 2008 May 15;232(10):1496-503. PubMed PMID: 18479239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical utility of serum N-terminal pro-B-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity. AU - Oyama,Mark A, AU - Fox,Philip R, AU - Rush,John E, AU - Rozanski,Elizabeth A, AU - Lesser,Mike, PY - 2008/5/16/pubmed PY - 2008/7/2/medline PY - 2008/5/16/entrez SP - 1496 EP - 503 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 232 IS - 10 N2 - OBJECTIVE: To determine whether serum N-terminal pro-B-type natriuretic (NT-proBNP) concentration could be used to identify cardiac disease in dogs and to assess disease severity in affected dogs. DESIGN: Cross-sectional study. ANIMALS: 119 dogs with mitral valve disease, 18 dogs with dilated cardiomyopathy, and 40 healthy control dogs. PROCEDURES: Serum NT-proBNP concentration was measured with an ELISA validated for use in dogs. Results of physical examination, thoracic radiography, echocardiography, and serum biochemical analyses were recorded for dogs with cardiac disease. RESULTS: Serum NT-proBNP concentration was significantly higher in dogs with cardiac disease than in control dogs, and a serum NT-proBNP concentration > 445 pmol/L could be used to discriminate dogs with cardiac disease from control dogs with a sensitivity of 83.2% and specificity of 90.0%. In dogs with cardiac disease, serum NT-proBNP concentration was correlated with heart rate, respiratory rate, echocardiographic heart size, and renal function. For dogs with cardiac disease, serum NT-proBNP concentration could be used to discriminate dogs with and without radiographic evidence of cardiomegaly and dogs with and without congestive heart failure. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that serum NT-proBNP concentration may be a useful adjunct clinical test for diagnosing cardiac disease in dogs and assessing the severity of disease in dogs with cardiac disease. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/18479239/Clinical_utility_of_serum_N_terminal_pro_B_type_natriuretic_peptide_concentration_for_identifying_cardiac_disease_in_dogs_and_assessing_disease_severity_ L2 - https://avmajournals.avma.org/doi/10.2460/javma.232.10.1496?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -